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Dietary Fat Intake and Development of Specific Breast Cancer Subtypes.

Sieri, Sabina; Chiodini, Paolo; Agnoli, Claudia; Pala, Valeria; Berrino, Franco; Trichopoulou, Antonia; Benetou, Vassiliki; Vasilopoulou, Effie; Sánchez, María-José and Chirlaque, Maria-Dolores, et al. (2014) In Journal of the National Cancer Institute 106(5). p.068-068
Abstract
We prospectively evaluated fat intake as predictor of developing breast cancer (BC) subtypes defined by estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor 2 receptor (HER2), in a large (n = 337327) heterogeneous cohort of women, with 10062 BC case patients after 11.5 years, estimating BC hazard ratios (HRs) by Cox proportional hazard modeling. High total and saturated fat were associated with greater risk of ER(+)PR(+) disease (HR = 1.20, 95% confidence interval [CI] = 1.00 to 1.45; HR = 1.28, 95% CI = 1.09 to 1.52; highest vs lowest quintiles) but not ER(-)PR(-) disease. High saturated fat was statistically significantly associated with greater risk of HER2(-) disease. High saturated fat intake... (More)
We prospectively evaluated fat intake as predictor of developing breast cancer (BC) subtypes defined by estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor 2 receptor (HER2), in a large (n = 337327) heterogeneous cohort of women, with 10062 BC case patients after 11.5 years, estimating BC hazard ratios (HRs) by Cox proportional hazard modeling. High total and saturated fat were associated with greater risk of ER(+)PR(+) disease (HR = 1.20, 95% confidence interval [CI] = 1.00 to 1.45; HR = 1.28, 95% CI = 1.09 to 1.52; highest vs lowest quintiles) but not ER(-)PR(-) disease. High saturated fat was statistically significantly associated with greater risk of HER2(-) disease. High saturated fat intake particularly increases risk of receptor-positive disease, suggesting saturated fat involvement in the etiology of this BC subtype. (Less)
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Contribution to journal
publication status
published
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in
Journal of the National Cancer Institute
volume
106
issue
5
pages
068 - 068
publisher
Oxford University Press
external identifiers
  • wos:000341636100013
  • pmid:24718872
  • scopus:84905196278
ISSN
1460-2105
DOI
10.1093/jnci/dju068
language
English
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yes
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19c7c17a-6afc-43f2-9ec0-c79658f082ea (old id 4430440)
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http://www.ncbi.nlm.nih.gov/pubmed/24718872?dopt=Abstract
date added to LUP
2014-05-05 21:45:00
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2017-10-22 03:18:44
@article{19c7c17a-6afc-43f2-9ec0-c79658f082ea,
  abstract     = {We prospectively evaluated fat intake as predictor of developing breast cancer (BC) subtypes defined by estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor 2 receptor (HER2), in a large (n = 337327) heterogeneous cohort of women, with 10062 BC case patients after 11.5 years, estimating BC hazard ratios (HRs) by Cox proportional hazard modeling. High total and saturated fat were associated with greater risk of ER(+)PR(+) disease (HR = 1.20, 95% confidence interval [CI] = 1.00 to 1.45; HR = 1.28, 95% CI = 1.09 to 1.52; highest vs lowest quintiles) but not ER(-)PR(-) disease. High saturated fat was statistically significantly associated with greater risk of HER2(-) disease. High saturated fat intake particularly increases risk of receptor-positive disease, suggesting saturated fat involvement in the etiology of this BC subtype.},
  author       = {Sieri, Sabina and Chiodini, Paolo and Agnoli, Claudia and Pala, Valeria and Berrino, Franco and Trichopoulou, Antonia and Benetou, Vassiliki and Vasilopoulou, Effie and Sánchez, María-José and Chirlaque, Maria-Dolores and Amiano, Pilar and Quirós, J Ramón and Ardanaz, Eva and Buckland, Genevieve and Masala, Giovanna and Panico, Salvatore and Grioni, Sara and Sacerdote, Carlotta and Tumino, Rosario and Boutron-Ruault, Marie-Christine and Clavel-Chapelon, Françoise and Fagherazzi, Guy and Peeters, Petra H M and van Gils, Carla H and Bueno-de-Mesquita, H Bas and van Kranen, Henk J and Key, Timothy J and Travis, Ruth C and Khaw, Kay Tee and Wareham, Nicholas J and Kaaks, Rudolf and Lukanova, Annekatrin and Boeing, Heiner and Schütze, Madlen and Sonestedt, Emily and Wirfält, Elisabet and Sund, Malin and Andersson, Anne and Chajes, Veronique and Rinaldi, Sabina and Romieu, Isabelle and Weiderpass, Elisabete and Skeie, Guri and Dagrun, Engeset and Tjønneland, Anne and Halkjær, Jytte and Overvard, Kim and Merritt, Melissa A and Cox, David and Riboli, Elio and Krogh, Vittorio},
  issn         = {1460-2105},
  language     = {eng},
  number       = {5},
  pages        = {068--068},
  publisher    = {Oxford University Press},
  series       = {Journal of the National Cancer Institute},
  title        = {Dietary Fat Intake and Development of Specific Breast Cancer Subtypes.},
  url          = {http://dx.doi.org/10.1093/jnci/dju068},
  volume       = {106},
  year         = {2014},
}