Short- and Long-Term Hormonal and Metabolic Consequences of Reversing Gastric Bypass to Normal Anatomy in a Type 2 Diabetes Patient.
(2015) In Obesity Surgery 25(1). p.180-185- Abstract
- Gastric bypass (GBP) results in rapid type 2 diabetes (T2D) remission in most cases. Consequences of GBP reversal are unknown. A GBP-operated T2D patient was given mixed-meal tests before (MMTpre), 2 months (MMT2-M) and 12 months (MMT12-M) after GBP reversal. Glucose, hormones and metabolite profiles were assessed. MMT2-M displayed slightly lower glucose levels; MMT12-M displayed higher glucose and insulin levels, indicating deteriorating glycaemia. Homeostasis model assessment (HOMA)-β was higher at MMT2-M, but reduced at MMT12-M. Matsuda index revealed slightly reduced insulin sensitivity at MMT2-M, which deteriorated further at MMT12-M. Markers for metabolic stress and insulin resistance were elevated at MMT12-M. Gastric inhibitory... (More)
- Gastric bypass (GBP) results in rapid type 2 diabetes (T2D) remission in most cases. Consequences of GBP reversal are unknown. A GBP-operated T2D patient was given mixed-meal tests before (MMTpre), 2 months (MMT2-M) and 12 months (MMT12-M) after GBP reversal. Glucose, hormones and metabolite profiles were assessed. MMT2-M displayed slightly lower glucose levels; MMT12-M displayed higher glucose and insulin levels, indicating deteriorating glycaemia. Homeostasis model assessment (HOMA)-β was higher at MMT2-M, but reduced at MMT12-M. Matsuda index revealed slightly reduced insulin sensitivity at MMT2-M, which deteriorated further at MMT12-M. Markers for metabolic stress and insulin resistance were elevated at MMT12-M. Gastric inhibitory polypeptide (GIP) levels were increased at MMT2-M and decreased at MMT12-M. Glucagon-like peptide-1 (GLP-1) decreased at MMT2-M and further decreased at MMT12-M. In conclusion, in this patient, GBP reversal provoked deteriorating glycaemia and long-term development of insulin resistance. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/4733738
- author
- Wierup, Nils LU ; Lindqvist, Andreas LU ; Spégel, Peter LU ; Groop, Leif LU ; Hedenbro, Jan LU and Ekelund, Mikael LU
- organization
- publishing date
- 2015
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Obesity Surgery
- volume
- 25
- issue
- 1
- pages
- 180 - 185
- publisher
- Springer
- external identifiers
-
- pmid:25330869
- wos:000346781300027
- scopus:84939964085
- pmid:25330869
- ISSN
- 1708-0428
- DOI
- 10.1007/s11695-014-1459-8
- language
- English
- LU publication?
- yes
- id
- 6f2eef86-cfdf-49bf-85aa-f04e6492cacd (old id 4733738)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/25330869?dopt=Abstract
- date added to LUP
- 2016-04-01 09:59:45
- date last changed
- 2024-02-04 17:10:21
@article{6f2eef86-cfdf-49bf-85aa-f04e6492cacd, abstract = {{Gastric bypass (GBP) results in rapid type 2 diabetes (T2D) remission in most cases. Consequences of GBP reversal are unknown. A GBP-operated T2D patient was given mixed-meal tests before (MMTpre), 2 months (MMT2-M) and 12 months (MMT12-M) after GBP reversal. Glucose, hormones and metabolite profiles were assessed. MMT2-M displayed slightly lower glucose levels; MMT12-M displayed higher glucose and insulin levels, indicating deteriorating glycaemia. Homeostasis model assessment (HOMA)-β was higher at MMT2-M, but reduced at MMT12-M. Matsuda index revealed slightly reduced insulin sensitivity at MMT2-M, which deteriorated further at MMT12-M. Markers for metabolic stress and insulin resistance were elevated at MMT12-M. Gastric inhibitory polypeptide (GIP) levels were increased at MMT2-M and decreased at MMT12-M. Glucagon-like peptide-1 (GLP-1) decreased at MMT2-M and further decreased at MMT12-M. In conclusion, in this patient, GBP reversal provoked deteriorating glycaemia and long-term development of insulin resistance.}}, author = {{Wierup, Nils and Lindqvist, Andreas and Spégel, Peter and Groop, Leif and Hedenbro, Jan and Ekelund, Mikael}}, issn = {{1708-0428}}, language = {{eng}}, number = {{1}}, pages = {{180--185}}, publisher = {{Springer}}, series = {{Obesity Surgery}}, title = {{Short- and Long-Term Hormonal and Metabolic Consequences of Reversing Gastric Bypass to Normal Anatomy in a Type 2 Diabetes Patient.}}, url = {{http://dx.doi.org/10.1007/s11695-014-1459-8}}, doi = {{10.1007/s11695-014-1459-8}}, volume = {{25}}, year = {{2015}}, }