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Short- and Long-Term Hormonal and Metabolic Consequences of Reversing Gastric Bypass to Normal Anatomy in a Type 2 Diabetes Patient.

Wierup, Nils LU ; Lindqvist, Andreas LU ; Spégel, Peter LU ; Groop, Leif LU ; Hedenbro, Jan LU and Ekelund, Mikael LU (2015) In Obesity Surgery 25(1). p.180-185
Abstract
Gastric bypass (GBP) results in rapid type 2 diabetes (T2D) remission in most cases. Consequences of GBP reversal are unknown. A GBP-operated T2D patient was given mixed-meal tests before (MMTpre), 2 months (MMT2-M) and 12 months (MMT12-M) after GBP reversal. Glucose, hormones and metabolite profiles were assessed. MMT2-M displayed slightly lower glucose levels; MMT12-M displayed higher glucose and insulin levels, indicating deteriorating glycaemia. Homeostasis model assessment (HOMA)-β was higher at MMT2-M, but reduced at MMT12-M. Matsuda index revealed slightly reduced insulin sensitivity at MMT2-M, which deteriorated further at MMT12-M. Markers for metabolic stress and insulin resistance were elevated at MMT12-M. Gastric inhibitory... (More)
Gastric bypass (GBP) results in rapid type 2 diabetes (T2D) remission in most cases. Consequences of GBP reversal are unknown. A GBP-operated T2D patient was given mixed-meal tests before (MMTpre), 2 months (MMT2-M) and 12 months (MMT12-M) after GBP reversal. Glucose, hormones and metabolite profiles were assessed. MMT2-M displayed slightly lower glucose levels; MMT12-M displayed higher glucose and insulin levels, indicating deteriorating glycaemia. Homeostasis model assessment (HOMA)-β was higher at MMT2-M, but reduced at MMT12-M. Matsuda index revealed slightly reduced insulin sensitivity at MMT2-M, which deteriorated further at MMT12-M. Markers for metabolic stress and insulin resistance were elevated at MMT12-M. Gastric inhibitory polypeptide (GIP) levels were increased at MMT2-M and decreased at MMT12-M. Glucagon-like peptide-1 (GLP-1) decreased at MMT2-M and further decreased at MMT12-M. In conclusion, in this patient, GBP reversal provoked deteriorating glycaemia and long-term development of insulin resistance. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Obesity Surgery
volume
25
issue
1
pages
180 - 185
publisher
Springer
external identifiers
  • pmid:25330869
  • wos:000346781300027
  • scopus:84939964085
ISSN
1708-0428
DOI
10.1007/s11695-014-1459-8
language
English
LU publication?
yes
id
6f2eef86-cfdf-49bf-85aa-f04e6492cacd (old id 4733738)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/25330869?dopt=Abstract
date added to LUP
2014-11-09 23:42:06
date last changed
2017-03-19 03:03:13
@article{6f2eef86-cfdf-49bf-85aa-f04e6492cacd,
  abstract     = {Gastric bypass (GBP) results in rapid type 2 diabetes (T2D) remission in most cases. Consequences of GBP reversal are unknown. A GBP-operated T2D patient was given mixed-meal tests before (MMTpre), 2 months (MMT2-M) and 12 months (MMT12-M) after GBP reversal. Glucose, hormones and metabolite profiles were assessed. MMT2-M displayed slightly lower glucose levels; MMT12-M displayed higher glucose and insulin levels, indicating deteriorating glycaemia. Homeostasis model assessment (HOMA)-β was higher at MMT2-M, but reduced at MMT12-M. Matsuda index revealed slightly reduced insulin sensitivity at MMT2-M, which deteriorated further at MMT12-M. Markers for metabolic stress and insulin resistance were elevated at MMT12-M. Gastric inhibitory polypeptide (GIP) levels were increased at MMT2-M and decreased at MMT12-M. Glucagon-like peptide-1 (GLP-1) decreased at MMT2-M and further decreased at MMT12-M. In conclusion, in this patient, GBP reversal provoked deteriorating glycaemia and long-term development of insulin resistance.},
  author       = {Wierup, Nils and Lindqvist, Andreas and Spégel, Peter and Groop, Leif and Hedenbro, Jan and Ekelund, Mikael},
  issn         = {1708-0428},
  language     = {eng},
  number       = {1},
  pages        = {180--185},
  publisher    = {Springer},
  series       = {Obesity Surgery},
  title        = {Short- and Long-Term Hormonal and Metabolic Consequences of Reversing Gastric Bypass to Normal Anatomy in a Type 2 Diabetes Patient.},
  url          = {http://dx.doi.org/10.1007/s11695-014-1459-8},
  volume       = {25},
  year         = {2015},
}