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Gait and balance among people with de novo vs. mild to moderate Parkinson’s disease

Lindholm, Beata LU ; Hagell, Peter LU ; Odin, Per LU orcid ; Dahlin, Lars LU orcid and Franzén, Erika (2022) 6th International Conference on Neurology and Brain Disorders (Virtual)
Abstract
We have investigated how a de novo cohort of people with Parkinson’s disease (PD) differs in terms of balance and gait function as well as frequency of near falls and falls in comparison to a cohort with mild to moderate PD that has been medicated for several years. Preliminary results (Table 1) showed that people with de novo PD have balance and gait impairments and that some have also experienced near falls and falls. On the contrary, the cohort with more advanced disease has significantly fewer motor symptoms, as shown in the UPDRS motor score, compared to those newly diagnosed. This is probably related to successful symptomatic medication in the more advanced cohort. Despite less motor symptoms, those with a more advanced disease... (More)
We have investigated how a de novo cohort of people with Parkinson’s disease (PD) differs in terms of balance and gait function as well as frequency of near falls and falls in comparison to a cohort with mild to moderate PD that has been medicated for several years. Preliminary results (Table 1) showed that people with de novo PD have balance and gait impairments and that some have also experienced near falls and falls. On the contrary, the cohort with more advanced disease has significantly fewer motor symptoms, as shown in the UPDRS motor score, compared to those newly diagnosed. This is probably related to successful symptomatic medication in the more advanced cohort. Despite less motor symptoms, those with a more advanced disease performed significantly worse on the balance-demanding tests (i.e., Timed Up and Go, Tandem Gait) and reported more near falls and falls. These results are consistent with previous studies reporting that dopaminergic medication improves motor symptoms, but has less effects on mobility and balance in PD. This indicates a need for balance-promoting efforts from an early stage of the disease. (Less)
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author
; ; ; and
organization
publishing date
type
Contribution to conference
publication status
published
subject
conference name
6th International Conference on Neurology and Brain Disorders (Virtual)
conference location
Orlando, United States
conference dates
2022-10-24 - 2022-10-26
language
English
LU publication?
yes
id
5023e881-89ec-407d-8d8a-2c6303456cde
date added to LUP
2022-10-30 20:56:39
date last changed
2022-12-13 02:28:53
@misc{5023e881-89ec-407d-8d8a-2c6303456cde,
  abstract     = {{We have investigated how a de novo cohort of people with Parkinson’s disease (PD) differs in terms of balance and gait function as well as frequency of near falls and falls in comparison to a cohort with mild to moderate PD that has been medicated for several years. Preliminary results (Table 1) showed that people with de novo PD have balance and gait impairments and that some have also experienced near falls and falls. On the contrary, the cohort with more advanced disease has significantly fewer motor symptoms, as shown in the UPDRS motor score, compared to those newly diagnosed. This is probably related to successful symptomatic medication in the more advanced cohort. Despite less motor symptoms, those with a more advanced disease performed significantly worse on the balance-demanding tests (i.e., Timed Up and Go, Tandem Gait) and reported more near falls and falls. These results are consistent with previous studies reporting that dopaminergic medication improves motor symptoms, but has less effects on mobility and balance in PD. This indicates a need for balance-promoting efforts from an early stage of the disease.}},
  author       = {{Lindholm, Beata and Hagell, Peter and Odin, Per and Dahlin, Lars and Franzén, Erika}},
  language     = {{eng}},
  month        = {{10}},
  title        = {{Gait and balance among people with de novo vs. mild to moderate Parkinson’s disease}},
  year         = {{2022}},
}