Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

On the effect of flavonoids and dietary fibre in lingonberries on atherosclerotic plaques, lipid profiles and gut microbiota composition in Apoe-/- mice

Liu, Jiyun LU ; Hefni, Mohammed E ; Witthöft, Cornelia M ; Bergström, Maria LU ; Burleigh, Stephen LU ; Nyman, Margareta LU and Hållenius, Frida LU orcid (2022) In International Journal of Food Sciences and Nutrition 73(8). p.1080-1090
Abstract
It has not been clarified whether the anti-atherosclerotic effect of
lingonberry can be ascribed to its content of flavonoids or dietary
fibre or both. The aim of this study was to evaluate the metabolic
effects of whole lingonberries compared with isolated flavonoid and
fibre fractions on atherosclerotic plaques, plasma lipid profiles, gut
microbiota and microbiota-dependent metabolites in an Apoe–/–
mouse model. Mice fed whole lingonberries showed the lowest amount of
atherosclerotic plaques, while mice fed the fibre fraction had the
highest formation of caecal butyric acid. Flavonoids, rather than
dietary fibre, were suggested to be the components that favour
... (More)
It has not been clarified whether the anti-atherosclerotic effect of
lingonberry can be ascribed to its content of flavonoids or dietary
fibre or both. The aim of this study was to evaluate the metabolic
effects of whole lingonberries compared with isolated flavonoid and
fibre fractions on atherosclerotic plaques, plasma lipid profiles, gut
microbiota and microbiota-dependent metabolites in an Apoe–/–
mouse model. Mice fed whole lingonberries showed the lowest amount of
atherosclerotic plaques, while mice fed the fibre fraction had the
highest formation of caecal butyric acid. Flavonoids, rather than
dietary fibre, were suggested to be the components that favour
proliferation of Akkermansia, as judged by the lowest abundance
of this bacterium in mice fed the fibre fraction. All groups fed
lingonberry diets had both, lower Firmicutes/Bacteroidetes ratios and
creatinine concentrations, compared with the control. To conclude,
different components in lingonberries are associated with different
physiological effects in Apoe–/– mice. (Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Food Sciences and Nutrition
volume
73
issue
8
pages
11 pages
publisher
Taylor & Francis
external identifiers
  • pmid:35930435
  • scopus:85135482678
ISSN
1465-3478
DOI
10.1080/09637486.2022.2106358
language
English
LU publication?
yes
id
59801f33-fa1f-4078-b88e-69df1e278a1b
date added to LUP
2022-08-15 10:08:59
date last changed
2025-03-18 23:30:49
@article{59801f33-fa1f-4078-b88e-69df1e278a1b,
  abstract     = {{It has not been clarified whether the anti-atherosclerotic effect of <br>
lingonberry can be ascribed to its content of flavonoids or dietary <br>
fibre or both. The aim of this study was to evaluate the metabolic <br>
effects of whole lingonberries compared with isolated flavonoid and <br>
fibre fractions on atherosclerotic plaques, plasma lipid profiles, gut <br>
microbiota and microbiota-dependent metabolites in an <i>Apoe</i><sup>–/–</sup><br>
 mouse model. Mice fed whole lingonberries showed the lowest amount of <br>
atherosclerotic plaques, while mice fed the fibre fraction had the <br>
highest formation of caecal butyric acid. Flavonoids, rather than <br>
dietary fibre, were suggested to be the components that favour <br>
proliferation of <i>Akkermansia</i>, as judged by the lowest abundance <br>
of this bacterium in mice fed the fibre fraction. All groups fed <br>
lingonberry diets had both, lower Firmicutes/Bacteroidetes ratios and <br>
creatinine concentrations, compared with the control. To conclude, <br>
different components in lingonberries are associated with different <br>
physiological effects in <i>Apoe</i><sup>–/–</sup> mice.}},
  author       = {{Liu, Jiyun and Hefni, Mohammed E and Witthöft, Cornelia M and Bergström, Maria and Burleigh, Stephen and Nyman, Margareta and Hållenius, Frida}},
  issn         = {{1465-3478}},
  language     = {{eng}},
  month        = {{08}},
  number       = {{8}},
  pages        = {{1080--1090}},
  publisher    = {{Taylor & Francis}},
  series       = {{International Journal of Food Sciences and Nutrition}},
  title        = {{On the effect of flavonoids and dietary fibre in lingonberries on atherosclerotic plaques, lipid profiles and gut microbiota composition in <i>        Apoe</i><sup>-/-</sup> mice}},
  url          = {{http://dx.doi.org/10.1080/09637486.2022.2106358}},
  doi          = {{10.1080/09637486.2022.2106358}},
  volume       = {{73}},
  year         = {{2022}},
}