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Serum biomarkers in patients with hand-arm vibration injury and in controls

Tekavec, Eva LU ; Nilsson, Tohr ; Dahlin, Lars B LU orcid ; Huynh, Elizabeth LU ; Axmon, Anna LU orcid ; Nordander, Catarina LU orcid ; Riddar, Jakob LU and Kåredal, Monica LU orcid (2024) In Scientific Reports 14. p.1-10
Abstract

Hand-arm vibration injury is a well-known occupational disorder that affects many workers globally. The diagnosis is based mainly on quantitative psychophysical tests and medical history. Typical manifestations of hand-arm vibration injury entail episodes of finger blanching, Raynaud's phenomenon (RP) and sensorineural symptoms from affected nerve fibres and mechanoreceptors in the skin. Differences in serum levels of 17 different biomarkers between 92 patients with hand-arm vibration injury and 51 controls were analysed. Patients with hand-arm vibration injury entailing RP and sensorineural manifestations showed elevated levels of biomarkers associated with endothelial injury or dysfunction, inflammation, vaso- or neuroprotective... (More)

Hand-arm vibration injury is a well-known occupational disorder that affects many workers globally. The diagnosis is based mainly on quantitative psychophysical tests and medical history. Typical manifestations of hand-arm vibration injury entail episodes of finger blanching, Raynaud's phenomenon (RP) and sensorineural symptoms from affected nerve fibres and mechanoreceptors in the skin. Differences in serum levels of 17 different biomarkers between 92 patients with hand-arm vibration injury and 51 controls were analysed. Patients with hand-arm vibration injury entailing RP and sensorineural manifestations showed elevated levels of biomarkers associated with endothelial injury or dysfunction, inflammation, vaso- or neuroprotective compensatory, or apoptotic mechanisms: intercellular adhesion molecule-1 (ICAM-1), monocyte chemoattractant protein-1 (MCP-1); thrombomodulin (TM), heat shock protein 27 (HSP27); von Willebrand factor, calcitonin gene-related peptide (CGRP) and caspase-3. This study adds important knowledge on pathophysiological mechanisms that can contribute to the implementation of a more objective method for diagnosis of hand-arm vibration injury.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scientific Reports
volume
14
article number
2719
pages
1 - 10
publisher
Nature Publishing Group
external identifiers
  • scopus:85183693560
  • pmid:38302542
ISSN
2045-2322
DOI
10.1038/s41598-024-52782-1
language
English
LU publication?
yes
additional info
© 2024. The Author(s).
id
5e43cc91-107a-4c87-9e9f-7485c9003960
date added to LUP
2024-02-05 07:37:43
date last changed
2024-04-17 18:58:23
@article{5e43cc91-107a-4c87-9e9f-7485c9003960,
  abstract     = {{<p>Hand-arm vibration injury is a well-known occupational disorder that affects many workers globally. The diagnosis is based mainly on quantitative psychophysical tests and medical history. Typical manifestations of hand-arm vibration injury entail episodes of finger blanching, Raynaud's phenomenon (RP) and sensorineural symptoms from affected nerve fibres and mechanoreceptors in the skin. Differences in serum levels of 17 different biomarkers between 92 patients with hand-arm vibration injury and 51 controls were analysed. Patients with hand-arm vibration injury entailing RP and sensorineural manifestations showed elevated levels of biomarkers associated with endothelial injury or dysfunction, inflammation, vaso- or neuroprotective compensatory, or apoptotic mechanisms: intercellular adhesion molecule-1 (ICAM-1), monocyte chemoattractant protein-1 (MCP-1); thrombomodulin (TM), heat shock protein 27 (HSP27); von Willebrand factor, calcitonin gene-related peptide (CGRP) and caspase-3. This study adds important knowledge on pathophysiological mechanisms that can contribute to the implementation of a more objective method for diagnosis of hand-arm vibration injury.</p>}},
  author       = {{Tekavec, Eva and Nilsson, Tohr and Dahlin, Lars B and Huynh, Elizabeth and Axmon, Anna and Nordander, Catarina and Riddar, Jakob and Kåredal, Monica}},
  issn         = {{2045-2322}},
  language     = {{eng}},
  month        = {{02}},
  pages        = {{1--10}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Scientific Reports}},
  title        = {{Serum biomarkers in patients with hand-arm vibration injury and in controls}},
  url          = {{http://dx.doi.org/10.1038/s41598-024-52782-1}},
  doi          = {{10.1038/s41598-024-52782-1}},
  volume       = {{14}},
  year         = {{2024}},
}