Platelet Serotonin Levels Are Associated with Plasma Soluble Leptin Receptor Concentrations in Normoglycemic Women
(2019) In Journal of Diabetes Research 2019.- Abstract
- Most peripheral serotonin (5-hydroxytryptamine (5HT)) is synthetized in the gut with platelets being its main circulating reservoir. 5HT is acting as a hormone in key organs to regulate glucose and lipid metabolism. However, the relation between platelet 5HT levels and traits related to glucose homeostasis and lipid metabolism in humans remains poorly explored. The objectives of this study were (a) to assess the association between platelet 5HT levels and plasma concentration of nonesterified fatty acids (NEFAs) and some adipokines including leptin and its soluble leptin receptor (sOb-R), (b) to assess the association between platelet 5HT levels and anthropometric traits and indexes of insulin secretion/sensitivity derived from oral... (More)
- Most peripheral serotonin (5-hydroxytryptamine (5HT)) is synthetized in the gut with platelets being its main circulating reservoir. 5HT is acting as a hormone in key organs to regulate glucose and lipid metabolism. However, the relation between platelet 5HT levels and traits related to glucose homeostasis and lipid metabolism in humans remains poorly explored. The objectives of this study were (a) to assess the association between platelet 5HT levels and plasma concentration of nonesterified fatty acids (NEFAs) and some adipokines including leptin and its soluble leptin receptor (sOb-R), (b) to assess the association between platelet 5HT levels and anthropometric traits and indexes of insulin secretion/sensitivity derived from oral glucose tolerance test (OGTT), and (c) to evaluate changes in platelet 5HT levels in response to OGTT. In a cross-sectional study, 59 normoglycemic women underwent a standard 2-hour OGTT. Plasma leptin, sOb-R, total and high molecular weight adiponectin, TNFα, and MCP1 were determined by immunoassays. Platelet 5HT levels and NEFAs were measured before and after OGTT. The free leptin index was calculated from leptin and sOb-R measurements. Insulin sensitivity indexes derived from OGTT (HOMA-S and Matsuda ISICOMP) and plasma NEFAs (Adipose-IR, Revised QUICKI) were also calculated. Our data show that among metabolic traits, platelet 5HT levels were associated with plasma sOb-R (, , corrected ). Platelet 5HT levels were reduced in response to OGTT ( vs platelets, ). In conclusion, platelet 5HT levels are positively associated with plasma sOb-R concentrations and reduced in response to glucose intake possibly indicating a role of peripheral 5HT in leptin-mediated appetite regulation. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/63ff9ead-1a5b-40ca-8b07-08917af2ffe5
- author
- Cataldo Buscunan, Rodrigo LU ; Suazo, José ; Olmos, Pablo ; Bravo, Carolina ; Galgani, José E. ; Fex, Malin LU ; Martínez, J. Alfredo and Santos, José L.
- organization
-
- Endocrine Cell Differentiation and Function (research group)
- StemTherapy: National Initiative on Stem Cells for Regenerative Therapy
- Stem Cell Center
- LUDC (Lund University Diabetes Centre)-lup-obsolete (research group)
- Diabetes - Molecular Metabolism (research group)
- Celiac Disease and Diabetes Unit (research group)
- Department of Clinical Sciences, Malmö
- publishing date
- 2019
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Diabetes Research
- volume
- 2019
- article number
- 2714049
- pages
- 11 pages
- publisher
- Hindawi Limited
- external identifiers
-
- scopus:85068231553
- pmid:31192261
- ISSN
- 2314-6753
- DOI
- 10.1155/2019/2714049
- language
- English
- LU publication?
- yes
- id
- 63ff9ead-1a5b-40ca-8b07-08917af2ffe5
- date added to LUP
- 2019-05-24 09:34:46
- date last changed
- 2022-08-25 19:14:57
@article{63ff9ead-1a5b-40ca-8b07-08917af2ffe5, abstract = {{Most peripheral serotonin (5-hydroxytryptamine (5HT)) is synthetized in the gut with platelets being its main circulating reservoir. 5HT is acting as a hormone in key organs to regulate glucose and lipid metabolism. However, the relation between platelet 5HT levels and traits related to glucose homeostasis and lipid metabolism in humans remains poorly explored. The objectives of this study were (a) to assess the association between platelet 5HT levels and plasma concentration of nonesterified fatty acids (NEFAs) and some adipokines including leptin and its soluble leptin receptor (sOb-R), (b) to assess the association between platelet 5HT levels and anthropometric traits and indexes of insulin secretion/sensitivity derived from oral glucose tolerance test (OGTT), and (c) to evaluate changes in platelet 5HT levels in response to OGTT. In a cross-sectional study, 59 normoglycemic women underwent a standard 2-hour OGTT. Plasma leptin, sOb-R, total and high molecular weight adiponectin, TNFα, and MCP1 were determined by immunoassays. Platelet 5HT levels and NEFAs were measured before and after OGTT. The free leptin index was calculated from leptin and sOb-R measurements. Insulin sensitivity indexes derived from OGTT (HOMA-S and Matsuda ISICOMP) and plasma NEFAs (Adipose-IR, Revised QUICKI) were also calculated. Our data show that among metabolic traits, platelet 5HT levels were associated with plasma sOb-R (, , corrected ). Platelet 5HT levels were reduced in response to OGTT ( vs platelets, ). In conclusion, platelet 5HT levels are positively associated with plasma sOb-R concentrations and reduced in response to glucose intake possibly indicating a role of peripheral 5HT in leptin-mediated appetite regulation.}}, author = {{Cataldo Buscunan, Rodrigo and Suazo, José and Olmos, Pablo and Bravo, Carolina and Galgani, José E. and Fex, Malin and Martínez, J. Alfredo and Santos, José L.}}, issn = {{2314-6753}}, language = {{eng}}, publisher = {{Hindawi Limited}}, series = {{Journal of Diabetes Research}}, title = {{Platelet Serotonin Levels Are Associated with Plasma Soluble Leptin Receptor Concentrations in Normoglycemic Women}}, url = {{http://dx.doi.org/10.1155/2019/2714049}}, doi = {{10.1155/2019/2714049}}, volume = {{2019}}, year = {{2019}}, }