High folate intake is associated with lower breast cancer incidence in postmenopausal women in the Malmo Diet and Cancer cohort
Ericson, Ulrika LU ; Sonestedt, Emily LU
; Gullberg, Bo
LU
; Olsson, Håkan
LU
and Wirfält, Elisabet
LU
(2007)
In American Journal of Clinical Nutrition
86(2).
p.434-443
- Abstract
- Background: Epidemiologic studies of associations between folate intake and breast cancer are inconclusive, but folate and other plant food nutrients appear protective in women at elevated risk. Objective: The objective was to examine the association between folate intake and the incidence of postmenopausal breast cancer. Design: This prospective study included all women aged >= 50 y (n = 11699) from the Malmo Diet and Cancer cohort. The mean follow-up time was 9.5 y. We used a modified diet-history method to collect nutrient intake data. At the end of follow-up, 392 incident invasive breast cancer cases were verified. We used proportional hazard regression to calculate hazard ratios (HRs). Results: Compared with the lowest quintile,... (More)
- Background: Epidemiologic studies of associations between folate intake and breast cancer are inconclusive, but folate and other plant food nutrients appear protective in women at elevated risk. Objective: The objective was to examine the association between folate intake and the incidence of postmenopausal breast cancer. Design: This prospective study included all women aged >= 50 y (n = 11699) from the Malmo Diet and Cancer cohort. The mean follow-up time was 9.5 y. We used a modified diet-history method to collect nutrient intake data. At the end of follow-up, 392 incident invasive breast cancer cases were verified. We used proportional hazard regression to calculate hazard ratios (HRs). Results: Compared with the lowest quintile, the incidence of invasive breast cancer was reduced in the highest quintile of dietary folate intake (HR: 0.56; 95% CI: 0.35, 0.90; Pfor trend = 0.02); total folate intake, including supplements (HR: 0.56; 95% CI: 0.34, 0.91; P for trend = 0.006); and dietary folate equivalents (HR: 0.59; 95% CI: 0.36, 0.97; P for trend = 0.01). Conclusion: A high folate intake was associated with a lower incidence of postmenopausal breast cancer in this cohort. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/656813
- author
- Ericson, Ulrika
LU
; Sonestedt, Emily
LU
; Gullberg, Bo
LU
; Olsson, Håkan
LU
and Wirfält, Elisabet
LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- breast cancer, folate, obesity, body mass index, diet, postmenopausal women, prospective study
- in
- American Journal of Clinical Nutrition
- volume
- 86
- issue
- 2
- pages
- 434 - 443
- publisher
- Oxford University Press
- external identifiers
-
- wos:000248629700023
- ISSN
- 1938-3207
- language
- English
- LU publication?
- yes
- id
- ba90193f-bb37-4a66-a163-c59fd5d3f51e (old id 656813)
- alternative location
- http://www.ajcn.org/cgi/content/abstract/86/2/434
- date added to LUP
- 2016-04-01 15:31:36
- date last changed
- 2019-03-08 03:12:34
@article{ba90193f-bb37-4a66-a163-c59fd5d3f51e,
abstract = {{Background: Epidemiologic studies of associations between folate intake and breast cancer are inconclusive, but folate and other plant food nutrients appear protective in women at elevated risk. Objective: The objective was to examine the association between folate intake and the incidence of postmenopausal breast cancer. Design: This prospective study included all women aged >= 50 y (n = 11699) from the Malmo Diet and Cancer cohort. The mean follow-up time was 9.5 y. We used a modified diet-history method to collect nutrient intake data. At the end of follow-up, 392 incident invasive breast cancer cases were verified. We used proportional hazard regression to calculate hazard ratios (HRs). Results: Compared with the lowest quintile, the incidence of invasive breast cancer was reduced in the highest quintile of dietary folate intake (HR: 0.56; 95% CI: 0.35, 0.90; Pfor trend = 0.02); total folate intake, including supplements (HR: 0.56; 95% CI: 0.34, 0.91; P for trend = 0.006); and dietary folate equivalents (HR: 0.59; 95% CI: 0.36, 0.97; P for trend = 0.01). Conclusion: A high folate intake was associated with a lower incidence of postmenopausal breast cancer in this cohort.}},
author = {{Ericson, Ulrika and Sonestedt, Emily and Gullberg, Bo and Olsson, Håkan and Wirfält, Elisabet}},
issn = {{1938-3207}},
keywords = {{breast cancer; folate; obesity; body mass index; diet; postmenopausal women; prospective study}},
language = {{eng}},
number = {{2}},
pages = {{434--443}},
publisher = {{Oxford University Press}},
series = {{American Journal of Clinical Nutrition}},
title = {{High folate intake is associated with lower breast cancer incidence in postmenopausal women in the Malmo Diet and Cancer cohort}},
url = {{http://www.ajcn.org/cgi/content/abstract/86/2/434}},
volume = {{86}},
year = {{2007}},
}