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High folate intake is associated with lower breast cancer incidence in postmenopausal women in the Malmo Diet and Cancer cohort

Ericson, Ulrika LU ; Sonestedt, Emily LU ; Gullberg, Bo LU ; Olsson, Håkan LU and Wirfält, Elisabet LU (2007) In American Journal of Clinical Nutrition 86(2). p.434-443
Abstract
Background: Epidemiologic studies of associations between folate intake and breast cancer are inconclusive, but folate and other plant food nutrients appear protective in women at elevated risk. Objective: The objective was to examine the association between folate intake and the incidence of postmenopausal breast cancer. Design: This prospective study included all women aged >= 50 y (n = 11699) from the Malmo Diet and Cancer cohort. The mean follow-up time was 9.5 y. We used a modified diet-history method to collect nutrient intake data. At the end of follow-up, 392 incident invasive breast cancer cases were verified. We used proportional hazard regression to calculate hazard ratios (HRs). Results: Compared with the lowest quintile,... (More)
Background: Epidemiologic studies of associations between folate intake and breast cancer are inconclusive, but folate and other plant food nutrients appear protective in women at elevated risk. Objective: The objective was to examine the association between folate intake and the incidence of postmenopausal breast cancer. Design: This prospective study included all women aged >= 50 y (n = 11699) from the Malmo Diet and Cancer cohort. The mean follow-up time was 9.5 y. We used a modified diet-history method to collect nutrient intake data. At the end of follow-up, 392 incident invasive breast cancer cases were verified. We used proportional hazard regression to calculate hazard ratios (HRs). Results: Compared with the lowest quintile, the incidence of invasive breast cancer was reduced in the highest quintile of dietary folate intake (HR: 0.56; 95% CI: 0.35, 0.90; Pfor trend = 0.02); total folate intake, including supplements (HR: 0.56; 95% CI: 0.34, 0.91; P for trend = 0.006); and dietary folate equivalents (HR: 0.59; 95% CI: 0.36, 0.97; P for trend = 0.01). Conclusion: A high folate intake was associated with a lower incidence of postmenopausal breast cancer in this cohort. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
breast cancer, folate, obesity, body mass index, diet, postmenopausal women, prospective study
in
American Journal of Clinical Nutrition
volume
86
issue
2
pages
434 - 443
publisher
American Society for Clinical Nutrition
external identifiers
  • wos:000248629700023
ISSN
1938-3207
language
English
LU publication?
yes
id
ba90193f-bb37-4a66-a163-c59fd5d3f51e (old id 656813)
alternative location
http://www.ajcn.org/cgi/content/abstract/86/2/434
date added to LUP
2007-12-10 16:42:53
date last changed
2016-04-16 03:03:21
@article{ba90193f-bb37-4a66-a163-c59fd5d3f51e,
  abstract     = {Background: Epidemiologic studies of associations between folate intake and breast cancer are inconclusive, but folate and other plant food nutrients appear protective in women at elevated risk. Objective: The objective was to examine the association between folate intake and the incidence of postmenopausal breast cancer. Design: This prospective study included all women aged >= 50 y (n = 11699) from the Malmo Diet and Cancer cohort. The mean follow-up time was 9.5 y. We used a modified diet-history method to collect nutrient intake data. At the end of follow-up, 392 incident invasive breast cancer cases were verified. We used proportional hazard regression to calculate hazard ratios (HRs). Results: Compared with the lowest quintile, the incidence of invasive breast cancer was reduced in the highest quintile of dietary folate intake (HR: 0.56; 95% CI: 0.35, 0.90; Pfor trend = 0.02); total folate intake, including supplements (HR: 0.56; 95% CI: 0.34, 0.91; P for trend = 0.006); and dietary folate equivalents (HR: 0.59; 95% CI: 0.36, 0.97; P for trend = 0.01). Conclusion: A high folate intake was associated with a lower incidence of postmenopausal breast cancer in this cohort.},
  author       = {Ericson, Ulrika and Sonestedt, Emily and Gullberg, Bo and Olsson, Håkan and Wirfält, Elisabet},
  issn         = {1938-3207},
  keyword      = {breast cancer,folate,obesity,body mass index,diet,postmenopausal women,prospective study},
  language     = {eng},
  number       = {2},
  pages        = {434--443},
  publisher    = {American Society for Clinical Nutrition},
  series       = {American Journal of Clinical Nutrition},
  title        = {High folate intake is associated with lower breast cancer incidence in postmenopausal women in the Malmo Diet and Cancer cohort},
  volume       = {86},
  year         = {2007},
}