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Alcohol intake and breast cancer in the European prospective investigation into cancer and nutrition

Romieu, Isabelle; Scoccianti, Chiara; Chajes, Veronique; de Batlle, Jordi; Biessy, Carine; Dossus, Laure; Baglietto, Laura; Clavel-Chapelon, Francoise; Overvad, Kim and Olsen, Anja, et al. (2015) In International Journal of Cancer 137(8). p.1921-1930
Abstract
Alcohol intake has been associated to breast cancer in pre and postmenopausal women; however results are inconclusive regarding tumor hormonal receptor status, and potential modifying factors like age at start drinking. Therefore, we investigated the relation between alcohol intake and the risk of breast cancer using prospective observational data from the European Prospective Investigation into Cancer and Nutrition (EPIC). Up to 334,850 women, aged 35-70 years at baseline, were recruited in ten European countries and followed up an average of 11 years. Alcohol intake at baseline and average lifetime alcohol intake were calculated from country-specific dietary and lifestyle questionnaires. The study outcomes were the Hazard ratios (HR) of... (More)
Alcohol intake has been associated to breast cancer in pre and postmenopausal women; however results are inconclusive regarding tumor hormonal receptor status, and potential modifying factors like age at start drinking. Therefore, we investigated the relation between alcohol intake and the risk of breast cancer using prospective observational data from the European Prospective Investigation into Cancer and Nutrition (EPIC). Up to 334,850 women, aged 35-70 years at baseline, were recruited in ten European countries and followed up an average of 11 years. Alcohol intake at baseline and average lifetime alcohol intake were calculated from country-specific dietary and lifestyle questionnaires. The study outcomes were the Hazard ratios (HR) of developing breast cancer according to hormonal receptor status. During 3,670,439 person-years, 11,576 incident breast cancer cases were diagnosed. Alcohol intake was significantly related to breast cancer risk, for each 10 g/day increase in alcohol intake the HR increased by 4.2% (95% CI: 2.7-5.8%). Taking 0 to 5 g/day as reference, alcohol intake of >5 to 15 g/day was related to a 5.9% increase in breast cancer risk (95% CI: 1-11%). Significant increasing trends were observed between alcohol intake and ER+/PR+, ER-/PR-, HER2- and ER-/PR-HER2- tumors. Breast cancer risk was stronger among women who started drinking prior to first full-time pregnancy. Overall, our results confirm the association between alcohol intake and both hormone receptor positive and hormone receptor negative breast tumors, suggesting that timing of exposure to alcohol drinking may affect the risk. Therefore, women should be advised to control their alcohol consumption. What's new? Although it is now established that alcohol consumption increases breast cancer risk, many questions remain. Using a prospective study design with 11,576 incident breast cancer cases across 10 European countries, the authors confirmed the increased risk of alcohol on breast cancer development. They further show that women who started drinking before their first full-term pregnancy have a higher risk than women who started afterwards. These effects were observed in hormone-receptor positive and -negative tumors pointing to non-hormonal pathways that need to be further investigated. (Less)
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keywords
prospective study, breast cancer, alcohol consumption
in
International Journal of Cancer
volume
137
issue
8
pages
1921 - 1930
publisher
John Wiley & Sons
external identifiers
  • wos:000359350600019
  • scopus:84938924341
ISSN
0020-7136
DOI
10.1002/ijc.29469
language
English
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yes
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a0affa47-1f2c-498b-a6d8-387cb66b9895 (old id 7972427)
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2015-10-01 07:36:30
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2017-11-12 03:10:34
@article{a0affa47-1f2c-498b-a6d8-387cb66b9895,
  abstract     = {Alcohol intake has been associated to breast cancer in pre and postmenopausal women; however results are inconclusive regarding tumor hormonal receptor status, and potential modifying factors like age at start drinking. Therefore, we investigated the relation between alcohol intake and the risk of breast cancer using prospective observational data from the European Prospective Investigation into Cancer and Nutrition (EPIC). Up to 334,850 women, aged 35-70 years at baseline, were recruited in ten European countries and followed up an average of 11 years. Alcohol intake at baseline and average lifetime alcohol intake were calculated from country-specific dietary and lifestyle questionnaires. The study outcomes were the Hazard ratios (HR) of developing breast cancer according to hormonal receptor status. During 3,670,439 person-years, 11,576 incident breast cancer cases were diagnosed. Alcohol intake was significantly related to breast cancer risk, for each 10 g/day increase in alcohol intake the HR increased by 4.2% (95% CI: 2.7-5.8%). Taking 0 to 5 g/day as reference, alcohol intake of >5 to 15 g/day was related to a 5.9% increase in breast cancer risk (95% CI: 1-11%). Significant increasing trends were observed between alcohol intake and ER+/PR+, ER-/PR-, HER2- and ER-/PR-HER2- tumors. Breast cancer risk was stronger among women who started drinking prior to first full-time pregnancy. Overall, our results confirm the association between alcohol intake and both hormone receptor positive and hormone receptor negative breast tumors, suggesting that timing of exposure to alcohol drinking may affect the risk. Therefore, women should be advised to control their alcohol consumption. What's new? Although it is now established that alcohol consumption increases breast cancer risk, many questions remain. Using a prospective study design with 11,576 incident breast cancer cases across 10 European countries, the authors confirmed the increased risk of alcohol on breast cancer development. They further show that women who started drinking before their first full-term pregnancy have a higher risk than women who started afterwards. These effects were observed in hormone-receptor positive and -negative tumors pointing to non-hormonal pathways that need to be further investigated.},
  author       = {Romieu, Isabelle and Scoccianti, Chiara and Chajes, Veronique and de Batlle, Jordi and Biessy, Carine and Dossus, Laure and Baglietto, Laura and Clavel-Chapelon, Francoise and Overvad, Kim and Olsen, Anja and Tjonneland, Anne and Kaaks, Rudolf and Lukanova, Annekatrin and Boeing, Heiner and Trichopoulou, Antonia and Lagiou, Pagona and Trichopoulos, Dimitrios and Palli, Domenico and Sieri, Sabina and Tumino, Rosario and Vineis, Paolo and Panico, Salvatore and Bueno-de-Mesquita, H. B(as) and van Gils, Carla H. and Peeters, Petra H. and Lund, Eiliv and Skeie, Guri and Weiderpass, Elisabete and Quiros Garcia, Jose Ramon and Chirlaque, Maria-Dolores and Ardanaz, Eva and Sanchez, Maria-Jose and Duell, Eric J. and Amiano, Pilar and Borgquist, Signe and Wirfält, Elisabet and Hallmans, Goran and Johansson, Ingegerd and Nilsson, Lena Maria and Khaw, Kay-Tee and Wareham, Nick and Key, Timothy J. and Travis, Ruth C. and Murphy, Neil and Wark, Petra A. and Ferrari, Pietro and Riboli, Elio},
  issn         = {0020-7136},
  keyword      = {prospective study,breast cancer,alcohol consumption},
  language     = {eng},
  number       = {8},
  pages        = {1921--1930},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Alcohol intake and breast cancer in the European prospective investigation into cancer and nutrition},
  url          = {http://dx.doi.org/10.1002/ijc.29469},
  volume       = {137},
  year         = {2015},
}