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Comparative burden of arthropathy in mild haemophilia : a register-based study in Sweden

Osooli, M LU ; Lövdahl, S LU ; Steen Carlsson, K LU ; Knobe, K LU ; Baghaei, F.; Holmström, M; Astermark, J LU and Berntorp, E LU (2017) In Haemophilia 23(2). p.79-86
Abstract

INTRODUCTION: Mild haemophilia is a congenital bleeding disorder affecting males. The burden of arthropathy in mild haemophilia has not been comprehensively described.

AIM: The aim of this study was to compare the incidence, age at diagnosis and surgery for arthropathy and related hospitalizations between people with mild haemophilia and the general population in Sweden.

METHODS: This was a register-based cohort study. Eligible participants were those with mild haemophilia born between 1941 and 2008 and a randomly selected, birthdate and sex-matched comparison group from the general population. Follow-up was from birth (or earliest 1984) until death, emigration or end of the study in 2008. Data on arthropathy were obtained... (More)

INTRODUCTION: Mild haemophilia is a congenital bleeding disorder affecting males. The burden of arthropathy in mild haemophilia has not been comprehensively described.

AIM: The aim of this study was to compare the incidence, age at diagnosis and surgery for arthropathy and related hospitalizations between people with mild haemophilia and the general population in Sweden.

METHODS: This was a register-based cohort study. Eligible participants were those with mild haemophilia born between 1941 and 2008 and a randomly selected, birthdate and sex-matched comparison group from the general population. Follow-up was from birth (or earliest 1984) until death, emigration or end of the study in 2008. Data on arthropathy were obtained from a national patient register. Negative binomial and competing risk regression and Kaplan-Meier estimate curves were used in the analysis.

RESULTS: Overall, 315 people with haemophilia and 1529 people in the comparison group were included. Participants with haemophilia born between 1984 and 2008 had a ninefold (95% CI: 3.3-27.2) and 16-fold (95% CI: 6.7-36.5) increased incidence of arthropathy-related hospital admission and arthropathy diagnosis respectively. None in this cohort underwent surgery. Among participants with haemophilia born prior to 1984, the rates of arthropathy diagnosis and surgery of the index joints (knee, elbow, ankle) were increased twofold (95% CI: 1.0-3.2) and fivefold (95% CI: 1.7-17.8) respectively.

CONCLUSION: Our data suggested a higher burden of arthropathy among individuals with mild haemophilia compared to the general population. Further research should investigate the need for targeted joint screening programmes among individuals with mild haemophilia.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cohort Studies, Female, Hemophilia A, Hemophilia B, Humans, Joint Diseases, Male, Sweden
in
Haemophilia
volume
23
issue
2
pages
79 - 86
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • scopus:85011676256
  • wos:000397406000022
ISSN
1351-8216
DOI
10.1111/hae.13166
language
English
LU publication?
yes
id
79bd6c87-eb53-4ac1-a497-497d6ecb3b07
date added to LUP
2017-04-13 13:11:10
date last changed
2018-01-07 11:59:20
@article{79bd6c87-eb53-4ac1-a497-497d6ecb3b07,
  abstract     = {<p>INTRODUCTION: Mild haemophilia is a congenital bleeding disorder affecting males. The burden of arthropathy in mild haemophilia has not been comprehensively described.</p><p>AIM: The aim of this study was to compare the incidence, age at diagnosis and surgery for arthropathy and related hospitalizations between people with mild haemophilia and the general population in Sweden.</p><p>METHODS: This was a register-based cohort study. Eligible participants were those with mild haemophilia born between 1941 and 2008 and a randomly selected, birthdate and sex-matched comparison group from the general population. Follow-up was from birth (or earliest 1984) until death, emigration or end of the study in 2008. Data on arthropathy were obtained from a national patient register. Negative binomial and competing risk regression and Kaplan-Meier estimate curves were used in the analysis.</p><p>RESULTS: Overall, 315 people with haemophilia and 1529 people in the comparison group were included. Participants with haemophilia born between 1984 and 2008 had a ninefold (95% CI: 3.3-27.2) and 16-fold (95% CI: 6.7-36.5) increased incidence of arthropathy-related hospital admission and arthropathy diagnosis respectively. None in this cohort underwent surgery. Among participants with haemophilia born prior to 1984, the rates of arthropathy diagnosis and surgery of the index joints (knee, elbow, ankle) were increased twofold (95% CI: 1.0-3.2) and fivefold (95% CI: 1.7-17.8) respectively.</p><p>CONCLUSION: Our data suggested a higher burden of arthropathy among individuals with mild haemophilia compared to the general population. Further research should investigate the need for targeted joint screening programmes among individuals with mild haemophilia.</p>},
  author       = {Osooli, M and Lövdahl, S and Steen Carlsson, K and Knobe, K and Baghaei, F. and Holmström, M and Astermark, J and Berntorp, E},
  issn         = {1351-8216},
  keyword      = {Cohort Studies,Female,Hemophilia A,Hemophilia B,Humans,Joint Diseases,Male,Sweden},
  language     = {eng},
  number       = {2},
  pages        = {79--86},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Haemophilia},
  title        = {Comparative burden of arthropathy in mild haemophilia : a register-based study in Sweden},
  url          = {http://dx.doi.org/10.1111/hae.13166},
  volume       = {23},
  year         = {2017},
}