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Psychological manifestations of celiac disease autoimmunity in young children

Smith, Laura B.; Lynch, Kristian LU ; Kurppa, Kalle; Koletzko, Sibylle; Krischer, Jeffrey; Liu, Edwin; Johnson, Suzanne Bennett; Agardh, Daniel LU ; Rewers, Marian and Bautista, Kimberly, et al. (2017) In Pediatrics 139(3).
Abstract

BACKGROUND AND OBJECTIVES: Psychological symptoms can be associated with celiac disease; abstract however, this association has not been studied prospectively in a pediatric cohort. We examined mother report of psychological functioning in children persistently positive for tissue transglutaminase autoantibodies (tTGA), defined as celiac disease autoimmunity (CDA), compared with children without CDA in a screening population of genetically at-risk children. We also investigated differences in psychological symptoms based on mothers' awareness of their child's CDA status. METHODS: The Environmental Determinants of Diabetes in the Young study followed 8676 children to identify triggers of type 1 diabetes and celiac disease. Children were... (More)

BACKGROUND AND OBJECTIVES: Psychological symptoms can be associated with celiac disease; abstract however, this association has not been studied prospectively in a pediatric cohort. We examined mother report of psychological functioning in children persistently positive for tissue transglutaminase autoantibodies (tTGA), defined as celiac disease autoimmunity (CDA), compared with children without CDA in a screening population of genetically at-risk children. We also investigated differences in psychological symptoms based on mothers' awareness of their child's CDA status. METHODS: The Environmental Determinants of Diabetes in the Young study followed 8676 children to identify triggers of type 1 diabetes and celiac disease. Children were tested for tTGA beginning at 2 years of age. The Achenbach Child Behavior Checklist assessed child psychological functioning at 3.5 and 4.5 years of age. RESULTS: At 3.5 years, 66 mothers unaware their child had CDA reported more child anxiety and depression, aggressive behavior, and sleep problems than 3651 mothers of children without CDA (all Ps ≤ .03). Unaware-CDA mothers also reported more child anxiety and depression, withdrawn behavior, aggressive behavior, and sleep problems than 440 mothers aware of their child's CDA status (all Ps ≤.04). At 4.5 years, there were no differences. CONCLUSIONS: In 3.5-year-old children, CDA is associated with increased reports of child depression and anxiety, aggressive behavior, and sleep problems when mothers are unaware of their child's CDA status. Mothers' knowledge of their child's CDA status is associated with fewer reports of psychological symptoms, suggesting that awareness of the child's tTGA test results affects reporting of symptoms.

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published
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keywords
celiac disease, yong children, psychological
in
Pediatrics
volume
139
issue
3
publisher
American Academy of Pediatrics
external identifiers
  • scopus:85016036285
  • pmid:28219962
ISSN
0031-4005
DOI
10.1542/peds.2016-2848
language
English
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yes
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7c9044fb-7705-4481-9add-55b0b3b08d48
date added to LUP
2017-04-24 10:53:46
date last changed
2019-10-15 06:05:41
@article{7c9044fb-7705-4481-9add-55b0b3b08d48,
  abstract     = {<p>BACKGROUND AND OBJECTIVES: Psychological symptoms can be associated with celiac disease; abstract however, this association has not been studied prospectively in a pediatric cohort. We examined mother report of psychological functioning in children persistently positive for tissue transglutaminase autoantibodies (tTGA), defined as celiac disease autoimmunity (CDA), compared with children without CDA in a screening population of genetically at-risk children. We also investigated differences in psychological symptoms based on mothers' awareness of their child's CDA status. METHODS: The Environmental Determinants of Diabetes in the Young study followed 8676 children to identify triggers of type 1 diabetes and celiac disease. Children were tested for tTGA beginning at 2 years of age. The Achenbach Child Behavior Checklist assessed child psychological functioning at 3.5 and 4.5 years of age. RESULTS: At 3.5 years, 66 mothers unaware their child had CDA reported more child anxiety and depression, aggressive behavior, and sleep problems than 3651 mothers of children without CDA (all Ps ≤ .03). Unaware-CDA mothers also reported more child anxiety and depression, withdrawn behavior, aggressive behavior, and sleep problems than 440 mothers aware of their child's CDA status (all Ps ≤.04). At 4.5 years, there were no differences. CONCLUSIONS: In 3.5-year-old children, CDA is associated with increased reports of child depression and anxiety, aggressive behavior, and sleep problems when mothers are unaware of their child's CDA status. Mothers' knowledge of their child's CDA status is associated with fewer reports of psychological symptoms, suggesting that awareness of the child's tTGA test results affects reporting of symptoms.</p>},
  articleno    = {e20162848},
  author       = {Smith, Laura B. and Lynch, Kristian and Kurppa, Kalle and Koletzko, Sibylle and Krischer, Jeffrey and Liu, Edwin and Johnson, Suzanne Bennett and Agardh, Daniel and Rewers, Marian and Bautista, Kimberly and Baxter, Judith and Lernmark, Åke and Aronsson, Carin Andrén and Ask, Maria and Bremer, Jenny and Carlsson, Ulla Marie and Cilio, Corrado and Ericson-Hallström, Emelie and Fransson, Lina and Gard, Thomas and Gerardsson, Joanna and Bennet, Rasmus and Hansen, Monica and Hansson, Gertie and Harmby, Cecilia and Hyberg-Karlsson, Suzanne and Johansen, Fredrik and Jonsdottir, Berglind and Larsson, Helena Elding and Forss, Sigrid Lenrick and Lundgren, Markus and Månsson-Martinez, Maria and Markan, Maria and Melin, Marie Jessica and Mestan, Zeliha and Rahmati, Kobra and Ramelius, Anita and Rosenquist, Anna and Salami, Falastin and Sibthorpe, Sara and Sjöberg, Birgitta and Swartling, Ulrica and Amboh, Evelyn Tekum and Törn, Carina and Wallin, Anne and Wimar, Åsa and Åberg, Sofie and Lynch, Kristian and Parikh, Hemang and Vehik, Kendra and , },
  issn         = {0031-4005},
  keyword      = {celiac disease,yong children,psychological},
  language     = {eng},
  month        = {03},
  number       = {3},
  publisher    = {American Academy of Pediatrics},
  series       = {Pediatrics},
  title        = {Psychological manifestations of celiac disease autoimmunity in young children},
  url          = {http://dx.doi.org/10.1542/peds.2016-2848},
  volume       = {139},
  year         = {2017},
}