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Psychological manifestations of celiac disease autoimmunity in young children

Smith, Laura B.; Lynch, Kristian LU ; Kurppa, Kalle; Koletzko, Sibylle; Krischer, Jeffrey; Liu, Edwin; Johnson, Suzanne Bennett; Agardh, Daniel LU ; Rewers, Marian and Bautista, Kimberly, et al. (2017) In Pediatrics 139(3).
Abstract

BACKGROUND AND OBJECTIVES: Psychological symptoms can be associated with celiac disease; abstract however, this association has not been studied prospectively in a pediatric cohort. We examined mother report of psychological functioning in children persistently positive for tissue transglutaminase autoantibodies (tTGA), defined as celiac disease autoimmunity (CDA), compared with children without CDA in a screening population of genetically at-risk children. We also investigated differences in psychological symptoms based on mothers' awareness of their child's CDA status. METHODS: The Environmental Determinants of Diabetes in the Young study followed 8676 children to identify triggers of type 1 diabetes and celiac disease. Children were... (More)

BACKGROUND AND OBJECTIVES: Psychological symptoms can be associated with celiac disease; abstract however, this association has not been studied prospectively in a pediatric cohort. We examined mother report of psychological functioning in children persistently positive for tissue transglutaminase autoantibodies (tTGA), defined as celiac disease autoimmunity (CDA), compared with children without CDA in a screening population of genetically at-risk children. We also investigated differences in psychological symptoms based on mothers' awareness of their child's CDA status. METHODS: The Environmental Determinants of Diabetes in the Young study followed 8676 children to identify triggers of type 1 diabetes and celiac disease. Children were tested for tTGA beginning at 2 years of age. The Achenbach Child Behavior Checklist assessed child psychological functioning at 3.5 and 4.5 years of age. RESULTS: At 3.5 years, 66 mothers unaware their child had CDA reported more child anxiety and depression, aggressive behavior, and sleep problems than 3651 mothers of children without CDA (all Ps ≤ .03). Unaware-CDA mothers also reported more child anxiety and depression, withdrawn behavior, aggressive behavior, and sleep problems than 440 mothers aware of their child's CDA status (all Ps ≤.04). At 4.5 years, there were no differences. CONCLUSIONS: In 3.5-year-old children, CDA is associated with increased reports of child depression and anxiety, aggressive behavior, and sleep problems when mothers are unaware of their child's CDA status. Mothers' knowledge of their child's CDA status is associated with fewer reports of psychological symptoms, suggesting that awareness of the child's tTGA test results affects reporting of symptoms.

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keywords
celiac disease, yong children, psychological
in
Pediatrics
volume
139
issue
3
publisher
American Academy of Pediatrics
external identifiers
  • scopus:85016036285
  • pmid:28219962
ISSN
0031-4005
DOI
10.1542/peds.2016-2848
language
English
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yes
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7c9044fb-7705-4481-9add-55b0b3b08d48
date added to LUP
2017-04-24 10:53:46
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2018-01-07 12:00:36
@article{7c9044fb-7705-4481-9add-55b0b3b08d48,
  abstract     = {<p>BACKGROUND AND OBJECTIVES: Psychological symptoms can be associated with celiac disease; abstract however, this association has not been studied prospectively in a pediatric cohort. We examined mother report of psychological functioning in children persistently positive for tissue transglutaminase autoantibodies (tTGA), defined as celiac disease autoimmunity (CDA), compared with children without CDA in a screening population of genetically at-risk children. We also investigated differences in psychological symptoms based on mothers' awareness of their child's CDA status. METHODS: The Environmental Determinants of Diabetes in the Young study followed 8676 children to identify triggers of type 1 diabetes and celiac disease. Children were tested for tTGA beginning at 2 years of age. The Achenbach Child Behavior Checklist assessed child psychological functioning at 3.5 and 4.5 years of age. RESULTS: At 3.5 years, 66 mothers unaware their child had CDA reported more child anxiety and depression, aggressive behavior, and sleep problems than 3651 mothers of children without CDA (all Ps ≤ .03). Unaware-CDA mothers also reported more child anxiety and depression, withdrawn behavior, aggressive behavior, and sleep problems than 440 mothers aware of their child's CDA status (all Ps ≤.04). At 4.5 years, there were no differences. CONCLUSIONS: In 3.5-year-old children, CDA is associated with increased reports of child depression and anxiety, aggressive behavior, and sleep problems when mothers are unaware of their child's CDA status. Mothers' knowledge of their child's CDA status is associated with fewer reports of psychological symptoms, suggesting that awareness of the child's tTGA test results affects reporting of symptoms.</p>},
  articleno    = {e20162848},
  author       = {Smith, Laura B. and Lynch, Kristian and Kurppa, Kalle and Koletzko, Sibylle and Krischer, Jeffrey and Liu, Edwin and Johnson, Suzanne Bennett and Agardh, Daniel and Rewers, Marian and Bautista, Kimberly and Baxter, Judith and Bedoy, Ruth and Felipe-Morales, Daniel and Frohnert, Brigitte I. and Gesualdo, Patricia and Hoffman, Michelle and Karban, Rachel and Norris, Jill and Samper-Imaz, Adela and Steck, Andrea K and Waugh, Kathleen and Wright, Hali and She, Jin-Xiong and Schatz, Desmond and Hopkins, Diane and Steed, Leigh and Thomas, Jamie and Adams, Janey and Silvis, Katherine and Haller, Michael J. and Gardiner, Melissa and McIndoe, Richard and Sharma, Ashok and Williams, Joshua W and Young, Gabriela and Anderson, S and Jacobsen, Laura Mary and Ziegler, Anette-G and Beyerlein, Andreas and Bonifacio, Ezio and Hummel, Michael and Hummel, Sandra and Foterek, Kristina and Janz, Nicole and Kersting, Mathilde and Knopff, Annette and Peplow, Claudia and Roth, Roswith and Scholz, Marlon and Stock, Joanna and Strauss, Elisabeth and Warncke, Katharina and Wendel, Lorena and Winkler, Christiane and Toppari, Jorma and Simell, Olli G. and Adamsson, Annika and Ahonen, Suvi and Hyöty, Heikki and Ilonen, Jorma and Jokipuu, Sanna and Kallio, Tiina and Karlsson, Leena and Kähönen, Miia and Knip, Mikael and Kovanen, Lea and Koreasalo, Mirva and Latva-Aho, Tiina and Lönnrot, Maria and Mäntymäki, Elina and Multasuo, Katja and Mykkänen, Juha and Niininen, Tiina and Niinistö, Sari and Nyblom, Mia and Rajala, Petra and Rautanen, Jenna and Riikonen, Anne and Riikonen, Mika and Rouhiainen, Jenni and Romo, Minna and Simell, Tuula and Simell, Ville and Sjöberg, Maija and Stenius, Aino and Leppänen, Maria and Vainionpää, Sini and Varjonen, Eeva and Veijola, Riitta and Virtanen, Suvi M and Vähä-Mäkilä, Mari and Åkerlund, Mari and Lindfors, Katri and Lernmark, Åke and Aronsson, Carin Andrén and Ask, Maria and Bremer, Jenny and Carlsson, Ulla Marie and Cilio, Corrado and Ericson-Hallström, Emelie and Fransson, Lina and Gard, Thomas and Gerardsson, Joanna and Bennet, Rasmus and Hansen, Monica and Hansson, Gertie and Harmby, Cecilia and Hyberg-Karlsson, Suzanne and Johansen, Fredrik and Jonsdottir, Berglind and Larsson, Helena Elding and Forss, Sigrid Lenrick and Lundgren, Markus and Månsson-Martinez, Maria and Markan, Maria and Melin, Marie Jessica and Mestan, Zeliha and Rahmati, Kobra and Ramelius, Anita and Rosenquist, Anna and Salami, Falastin and Sibthorpe, Sara and Sjöberg, Birgitta and Swartling, Ulrica and Amboh, Evelyn Tekum and Törn, Carina and Wallin, Anne and Wimar, Åsa and Åberg, Sofie and Hagopian, William A. and Killian, Michael and Crouch, Claire Cowen and Skidmore, Jennifer and Carson, Josephine and Dunson, Kayleen and Hervey, Rachel and Johnson, Corbin and Lyons, Rachel and Meyer, Arlene and Mulenga, Denise and Schwartz, Allison and Stabbert, Joshua and Tarr, Alexander and Uland, Morgan and Willis, John and Becker, Dorothy and Franciscus, Margaret and Smith, Mary Ellen Dalmagro Elias and Daftary, Ashi and Klein, Mary Beth and Yates, Chrystal and Krischer, Jeffrey P and Abbondondolo, Michael and Austin-Gonzalez, Sarah and Avendano, Maryouri and Baethke, Sandra and Brown, Rasheedah and Burkhardt, Brant R. and Butterworth, Martha and Clasen, Joanna and Cuthbertson, David and Eberhard, Christopher and Fiske, Steven W. and Garcia, Dena and Garmeson, Jennifer and Gowda, Veena and Heyman, Kathleen and Laras, Francisco Perez and Lee, Hye-Seung and Liu, Shu and Liu, Xiang and Lynch, Kristian and Malloy, Jamie and McCarthy, Cristina and Meulemans, Steven and Parikh, Hemang and Shaffer, Chris and Smith, Laura and Smith, Susan and Sulman, Noah and Tamura, Roy N. and Uusitalo, Ulla and Vehik, Kendra and Vijayakandipan, Ponni and Wood, Keith and Yang, Jimin and Ballard, Lori and Hadley, David and Mcleod, Wendy and Akolkar, Beena and Erlich, Henry and Mack, Steven J. and Fear, Anna Lisa and Ke, Sandra and Mulholland, Niveen and Bourcier, Kasia and Briese, Thomas and Triplett, Eric W and , },
  issn         = {0031-4005},
  keyword      = {celiac disease,yong children,psychological},
  language     = {eng},
  month        = {03},
  number       = {3},
  publisher    = {American Academy of Pediatrics},
  series       = {Pediatrics},
  title        = {Psychological manifestations of celiac disease autoimmunity in young children},
  url          = {http://dx.doi.org/10.1542/peds.2016-2848},
  volume       = {139},
  year         = {2017},
}