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The EAT-Lancet diet, genetic susceptibility and risk of atrial fibrillation in a population-based cohort

Zhang, Shunming LU ; Stubbendorff, Anna LU orcid ; Ericson, Ulrika LU ; Wändell, Per LU ; Niu, Kaijun ; Qi, Lu ; Borné, Yan LU and Sonestedt, Emily LU orcid (2023) In BMC Medicine 21(1).
Abstract

BACKGROUND: The EAT-Lancet Commission proposed a global reference diet with both human health benefits and environmental sustainability in 2019. However, evidence regarding the association of such a diet with the risk of atrial fibrillation (AF) is lacking. In addition, whether the genetic risk of AF can modify the effect of diet on AF remains unclear. This study aimed to assess the association of the EAT-Lancet diet with the risk of incident AF and examine the interaction between the EAT-Lancet diet and genetic susceptibility of AF.

METHODS: This prospective study included 24,713 Swedish adults who were free of AF, coronary events, and stroke at baseline. Dietary habits were estimated with a modified diet history method, and an... (More)

BACKGROUND: The EAT-Lancet Commission proposed a global reference diet with both human health benefits and environmental sustainability in 2019. However, evidence regarding the association of such a diet with the risk of atrial fibrillation (AF) is lacking. In addition, whether the genetic risk of AF can modify the effect of diet on AF remains unclear. This study aimed to assess the association of the EAT-Lancet diet with the risk of incident AF and examine the interaction between the EAT-Lancet diet and genetic susceptibility of AF.

METHODS: This prospective study included 24,713 Swedish adults who were free of AF, coronary events, and stroke at baseline. Dietary habits were estimated with a modified diet history method, and an EAT-Lancet diet index was constructed to measure the EAT-Lancet reference diet. A weighted genetic risk score was constructed using 134 variants associated with AF. Cox proportional hazards regression models were applied to estimate the hazard ratio (HR) and 95% confidence interval (CI).

RESULTS: During a median follow-up of 22.9 years, 4617 (18.7%) participants were diagnosed with AF. The multivariable HR (95% CI) of AF for the highest versus the lowest group for the EAT-Lancet diet index was 0.84 (0.73, 0.98) (P for trend < 0.01). The HR (95% CI) of AF per one SD increment of the EAT-Lancet diet index for high genetic risk was 0.92 (0.87, 0.98) (P for interaction = 0.15).

CONCLUSIONS: Greater adherence to the EAT-Lancet diet index was significantly associated with a lower risk of incident AF. Such association tended to be stronger in participants with higher genetic risk, though gene-diet interaction was not significant.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adult, Humans, Atrial Fibrillation/epidemiology, Genetic Predisposition to Disease, Prospective Studies, Risk Factors, Diet/adverse effects
in
BMC Medicine
volume
21
issue
1
article number
280
publisher
BioMed Central (BMC)
external identifiers
  • scopus:85169847724
  • pmid:37507726
ISSN
1741-7015
DOI
10.1186/s12916-023-02985-6
language
English
LU publication?
yes
id
7c93a689-4bde-40d1-9b7b-ab5e5ebac40c
date added to LUP
2023-08-02 22:09:16
date last changed
2024-04-20 01:59:09
@article{7c93a689-4bde-40d1-9b7b-ab5e5ebac40c,
  abstract     = {{<p>BACKGROUND: The EAT-Lancet Commission proposed a global reference diet with both human health benefits and environmental sustainability in 2019. However, evidence regarding the association of such a diet with the risk of atrial fibrillation (AF) is lacking. In addition, whether the genetic risk of AF can modify the effect of diet on AF remains unclear. This study aimed to assess the association of the EAT-Lancet diet with the risk of incident AF and examine the interaction between the EAT-Lancet diet and genetic susceptibility of AF.</p><p>METHODS: This prospective study included 24,713 Swedish adults who were free of AF, coronary events, and stroke at baseline. Dietary habits were estimated with a modified diet history method, and an EAT-Lancet diet index was constructed to measure the EAT-Lancet reference diet. A weighted genetic risk score was constructed using 134 variants associated with AF. Cox proportional hazards regression models were applied to estimate the hazard ratio (HR) and 95% confidence interval (CI).</p><p>RESULTS: During a median follow-up of 22.9 years, 4617 (18.7%) participants were diagnosed with AF. The multivariable HR (95% CI) of AF for the highest versus the lowest group for the EAT-Lancet diet index was 0.84 (0.73, 0.98) (P for trend &lt; 0.01). The HR (95% CI) of AF per one SD increment of the EAT-Lancet diet index for high genetic risk was 0.92 (0.87, 0.98) (P for interaction = 0.15).</p><p>CONCLUSIONS: Greater adherence to the EAT-Lancet diet index was significantly associated with a lower risk of incident AF. Such association tended to be stronger in participants with higher genetic risk, though gene-diet interaction was not significant.</p>}},
  author       = {{Zhang, Shunming and Stubbendorff, Anna and Ericson, Ulrika and Wändell, Per and Niu, Kaijun and Qi, Lu and Borné, Yan and Sonestedt, Emily}},
  issn         = {{1741-7015}},
  keywords     = {{Adult; Humans; Atrial Fibrillation/epidemiology; Genetic Predisposition to Disease; Prospective Studies; Risk Factors; Diet/adverse effects}},
  language     = {{eng}},
  month        = {{07}},
  number       = {{1}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{BMC Medicine}},
  title        = {{The EAT-Lancet diet, genetic susceptibility and risk of atrial fibrillation in a population-based cohort}},
  url          = {{http://dx.doi.org/10.1186/s12916-023-02985-6}},
  doi          = {{10.1186/s12916-023-02985-6}},
  volume       = {{21}},
  year         = {{2023}},
}