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Plasma enterolactone and risk of prostate cancer in middle-aged Swedish men

Wallström, Peter LU ; Drake, Isabel LU ; Sonestedt, Emily LU ; Gullberg, Bo LU ; Bjartell, Anders LU ; Olsson, Håkan LU ; Adlercreutz, Herman; Tikkanen, Matti J and Wirfält, Elisabet LU (2017) In European Journal of Nutrition
Abstract

Purpose: Enterolactone (ENL) is formed in the human gut after consumption of lignans, has estrogenic properties, and has been associated with risk of prostate cancer. We examined the association between plasma ENL levels and prostate cancer in a nested case–control study within the population-based Malmö Diet and Cancer cohort. We also examined the association between plasma ENL and dietary and lifestyle factors. Methods: The study population consisted of 1010 cases occurring during a mean follow-up of 14.6 years, and 1817 controls matched on age and study entry date. We used national registers (95%) and hospital records (5%) to ascertain cases. Diet was estimated by a modified diet history method. Plasma ENL concentrations were... (More)

Purpose: Enterolactone (ENL) is formed in the human gut after consumption of lignans, has estrogenic properties, and has been associated with risk of prostate cancer. We examined the association between plasma ENL levels and prostate cancer in a nested case–control study within the population-based Malmö Diet and Cancer cohort. We also examined the association between plasma ENL and dietary and lifestyle factors. Methods: The study population consisted of 1010 cases occurring during a mean follow-up of 14.6 years, and 1817 controls matched on age and study entry date. We used national registers (95%) and hospital records (5%) to ascertain cases. Diet was estimated by a modified diet history method. Plasma ENL concentrations were determined by a time-resolved fluoroimmunoassay. Odds ratios were calculated by unconditional logistic regression. Results: There were no significant associations between plasma ENL and incidence of all prostate cancer (odds ratio 0.99 [95% confidence interval 0.77–1.280] for the highest ENL quintile versus lowest, p for trend 0.66). However, in certain subgroups of men, including men with abdominal obesity (p for interaction = 0.012), we observed associations between high ENL levels and lower odds of high-risk prostate cancer. Plasma ENL was positively associated with consumption of high-fibre bread, fruit, tea, and coffee; with age, and with height, while it was negatively associated with smoking and waist circumference; however, although significant, all associations were rather weak (r ≤ |0.14|). Conclusion: ENL concentration was not consistently associated with lower prostate cancer risk, although it was weakly associated with a healthy lifestyle.

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author
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
Diet, Enterolactone, Lignans, Nested case–control, Prostate cancer
in
European Journal of Nutrition
pages
12 pages
publisher
Springer
external identifiers
  • scopus:85028966996
  • pmid:28884432
ISSN
1436-6207
DOI
10.1007/s00394-017-1530-z
language
English
LU publication?
yes
id
7ca8e90c-9409-4649-aae7-49e126718b6e
date added to LUP
2017-10-09 10:32:55
date last changed
2018-01-07 12:21:18
@article{7ca8e90c-9409-4649-aae7-49e126718b6e,
  abstract     = {<p>Purpose: Enterolactone (ENL) is formed in the human gut after consumption of lignans, has estrogenic properties, and has been associated with risk of prostate cancer. We examined the association between plasma ENL levels and prostate cancer in a nested case–control study within the population-based Malmö Diet and Cancer cohort. We also examined the association between plasma ENL and dietary and lifestyle factors. Methods: The study population consisted of 1010 cases occurring during a mean follow-up of 14.6 years, and 1817 controls matched on age and study entry date. We used national registers (95%) and hospital records (5%) to ascertain cases. Diet was estimated by a modified diet history method. Plasma ENL concentrations were determined by a time-resolved fluoroimmunoassay. Odds ratios were calculated by unconditional logistic regression. Results: There were no significant associations between plasma ENL and incidence of all prostate cancer (odds ratio 0.99 [95% confidence interval 0.77–1.280] for the highest ENL quintile versus lowest, p for trend 0.66). However, in certain subgroups of men, including men with abdominal obesity (p for interaction = 0.012), we observed associations between high ENL levels and lower odds of high-risk prostate cancer. Plasma ENL was positively associated with consumption of high-fibre bread, fruit, tea, and coffee; with age, and with height, while it was negatively associated with smoking and waist circumference; however, although significant, all associations were rather weak (r ≤ |0.14|). Conclusion: ENL concentration was not consistently associated with lower prostate cancer risk, although it was weakly associated with a healthy lifestyle.</p>},
  author       = {Wallström, Peter and Drake, Isabel and Sonestedt, Emily and Gullberg, Bo and Bjartell, Anders and Olsson, Håkan and Adlercreutz, Herman and Tikkanen, Matti J and Wirfält, Elisabet},
  issn         = {1436-6207},
  keyword      = {Diet,Enterolactone,Lignans,Nested case–control,Prostate cancer},
  language     = {eng},
  month        = {09},
  pages        = {12},
  publisher    = {Springer},
  series       = {European Journal of Nutrition},
  title        = {Plasma enterolactone and risk of prostate cancer in middle-aged Swedish men},
  url          = {http://dx.doi.org/10.1007/s00394-017-1530-z},
  year         = {2017},
}