Sweetened beverages are associated with a higher risk of differentiated thyroid cancer in the EPIC cohort : a dietary pattern approach
(2023) In European Journal of Nutrition 62(1). p.105-114- Abstract
Background: Dietary pattern analysis has gained particular interest, because it reflects the complexity of dietary intake. The aim of this study was to explore the associations between a posteriori dietary patterns, derived using a data-driven approach, and the risk of differentiated thyroid cancer (TC) in Europe. Methods: This investigation included 450,064 adults from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Dietary intake was assessed using validated country-specific dietary questionnaires. A posteriori dietary patterns were computed using principal component analyses. Cox regression was used to calculate multivariable adjusted hazard ratios (HRs) and 95% confidence intervals (CIs). Results:... (More)
Background: Dietary pattern analysis has gained particular interest, because it reflects the complexity of dietary intake. The aim of this study was to explore the associations between a posteriori dietary patterns, derived using a data-driven approach, and the risk of differentiated thyroid cancer (TC) in Europe. Methods: This investigation included 450,064 adults from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Dietary intake was assessed using validated country-specific dietary questionnaires. A posteriori dietary patterns were computed using principal component analyses. Cox regression was used to calculate multivariable adjusted hazard ratios (HRs) and 95% confidence intervals (CIs). Results: After a mean follow-up time of 14 years, 712 first differentiated TCs were diagnosed. In the fully adjusted model, a dietary pattern characterized by alcohol consumption (basically beer and wine) was negatively associated with differentiated TC risk (HRQ4vs.Q1 = 0.75; 95% CI:0.60–0.94, P-trend = 0.005), while a dietary pattern rich in sweetened beverages was positively associated with differentiated TC risk (HRQ4vs.Q1 = 1.26; 95% CI:0.99–1.61; P-trend = 0.07). The remaining 8 dietary patterns were not related to differentiated TC risk. The intake of sweetened beverages was positively associated with differentiated TC risk (HR100mL/d = 1.05; 95% CI:1.00–1.11), especially with papillary TC risk (HR100mL/d = 1.07; 95% CI:1.01–1.13). Similar results were observed with sugary and artificially sweetened beverages. Conclusions: The investigation of dietary patterns detected that the consumption of sweetened beverages was associated with a higher risk of differentiated thyroid cancer. Our results are in line with the general dietary recommendations of reducing the consumption of sweetened beverages.
(Less)
- author
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Dietary pattern, EPIC, Intake, Sweetened beverages, Thyroid cancer
- in
- European Journal of Nutrition
- volume
- 62
- issue
- 1
- pages
- 105 - 114
- publisher
- Springer
- external identifiers
-
- scopus:85135267887
- pmid:35907037
- ISSN
- 1436-6207
- DOI
- 10.1007/s00394-022-02953-5
- language
- English
- LU publication?
- yes
- id
- 7debeb87-7c76-4f47-9876-42fb2233c73d
- date added to LUP
- 2022-10-21 09:57:32
- date last changed
- 2024-04-18 15:08:15
@article{7debeb87-7c76-4f47-9876-42fb2233c73d,
abstract = {{<p>Background: Dietary pattern analysis has gained particular interest, because it reflects the complexity of dietary intake. The aim of this study was to explore the associations between a posteriori dietary patterns, derived using a data-driven approach, and the risk of differentiated thyroid cancer (TC) in Europe. Methods: This investigation included 450,064 adults from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Dietary intake was assessed using validated country-specific dietary questionnaires. A posteriori dietary patterns were computed using principal component analyses. Cox regression was used to calculate multivariable adjusted hazard ratios (HRs) and 95% confidence intervals (CIs). Results: After a mean follow-up time of 14 years, 712 first differentiated TCs were diagnosed. In the fully adjusted model, a dietary pattern characterized by alcohol consumption (basically beer and wine) was negatively associated with differentiated TC risk (HR<sub>Q4vs.Q1</sub> = 0.75; 95% CI:0.60–0.94, P-trend = 0.005), while a dietary pattern rich in sweetened beverages was positively associated with differentiated TC risk (HR<sub>Q4vs.Q1</sub> = 1.26; 95% CI:0.99–1.61; P-trend = 0.07). The remaining 8 dietary patterns were not related to differentiated TC risk. The intake of sweetened beverages was positively associated with differentiated TC risk (HR<sub>100mL/d</sub> = 1.05; 95% CI:1.00–1.11), especially with papillary TC risk (HR<sub>100mL/d</sub> = 1.07; 95% CI:1.01–1.13). Similar results were observed with sugary and artificially sweetened beverages. Conclusions: The investigation of dietary patterns detected that the consumption of sweetened beverages was associated with a higher risk of differentiated thyroid cancer. Our results are in line with the general dietary recommendations of reducing the consumption of sweetened beverages.</p>}},
author = {{Zamora-Ros, Raul and Cayssials, Valerie and Clèries, Ramon and Torrents, Maria and Byrnes, Graham and Weiderpass, Elisabete and Sandström, Maria and Almquist, Martin and Boutron-Ruault, Marie Christine and Tjønneland, Anne and Kyrø, Cecilie and Katzke, Verena A. and Le Cornet, Charlotte and Masala, Giovanna and Krogh, Vittorio and Iannuzzo, Gabriella and Tumino, Rosario and Milani, Lorenzo and Skeie, Guri and Ubago-Guisado, Esther and Amiano, Pilar and Chirlaque, María Dolores and Ardanaz, Eva and Janzi, Suzanne and Eriksson, Linda and Freisling, Heinz and Heath, Alicia K. and Rinaldi, Sabina and Agudo, Antonio}},
issn = {{1436-6207}},
keywords = {{Dietary pattern; EPIC; Intake; Sweetened beverages; Thyroid cancer}},
language = {{eng}},
number = {{1}},
pages = {{105--114}},
publisher = {{Springer}},
series = {{European Journal of Nutrition}},
title = {{Sweetened beverages are associated with a higher risk of differentiated thyroid cancer in the EPIC cohort : a dietary pattern approach}},
url = {{http://dx.doi.org/10.1007/s00394-022-02953-5}},
doi = {{10.1007/s00394-022-02953-5}},
volume = {{62}},
year = {{2023}},
}