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Sweetened beverages are associated with a higher risk of differentiated thyroid cancer in the EPIC cohort : a dietary pattern approach

Zamora-Ros, Raul ; Cayssials, Valerie ; Clèries, Ramon ; Torrents, Maria ; Byrnes, Graham ; Weiderpass, Elisabete ; Sandström, Maria ; Almquist, Martin LU ; Boutron-Ruault, Marie Christine and Tjønneland, Anne , et al. (2023) In European Journal of Nutrition 62(1). p.105-114
Abstract

Background: Dietary pattern analysis has gained particular interest, because it reflects the complexity of dietary intake. The aim of this study was to explore the associations between a posteriori dietary patterns, derived using a data-driven approach, and the risk of differentiated thyroid cancer (TC) in Europe. Methods: This investigation included 450,064 adults from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Dietary intake was assessed using validated country-specific dietary questionnaires. A posteriori dietary patterns were computed using principal component analyses. Cox regression was used to calculate multivariable adjusted hazard ratios (HRs) and 95% confidence intervals (CIs). Results:... (More)

Background: Dietary pattern analysis has gained particular interest, because it reflects the complexity of dietary intake. The aim of this study was to explore the associations between a posteriori dietary patterns, derived using a data-driven approach, and the risk of differentiated thyroid cancer (TC) in Europe. Methods: This investigation included 450,064 adults from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Dietary intake was assessed using validated country-specific dietary questionnaires. A posteriori dietary patterns were computed using principal component analyses. Cox regression was used to calculate multivariable adjusted hazard ratios (HRs) and 95% confidence intervals (CIs). Results: After a mean follow-up time of 14 years, 712 first differentiated TCs were diagnosed. In the fully adjusted model, a dietary pattern characterized by alcohol consumption (basically beer and wine) was negatively associated with differentiated TC risk (HRQ4vs.Q1 = 0.75; 95% CI:0.60–0.94, P-trend = 0.005), while a dietary pattern rich in sweetened beverages was positively associated with differentiated TC risk (HRQ4vs.Q1 = 1.26; 95% CI:0.99–1.61; P-trend = 0.07). The remaining 8 dietary patterns were not related to differentiated TC risk. The intake of sweetened beverages was positively associated with differentiated TC risk (HR100mL/d = 1.05; 95% CI:1.00–1.11), especially with papillary TC risk (HR100mL/d = 1.07; 95% CI:1.01–1.13). Similar results were observed with sugary and artificially sweetened beverages. Conclusions: The investigation of dietary patterns detected that the consumption of sweetened beverages was associated with a higher risk of differentiated thyroid cancer. Our results are in line with the general dietary recommendations of reducing the consumption of sweetened beverages.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Dietary pattern, EPIC, Intake, Sweetened beverages, Thyroid cancer
in
European Journal of Nutrition
volume
62
issue
1
pages
105 - 114
publisher
Springer
external identifiers
  • scopus:85135267887
  • pmid:35907037
ISSN
1436-6207
DOI
10.1007/s00394-022-02953-5
language
English
LU publication?
yes
id
7debeb87-7c76-4f47-9876-42fb2233c73d
date added to LUP
2022-10-21 09:57:32
date last changed
2024-11-01 10:59:14
@article{7debeb87-7c76-4f47-9876-42fb2233c73d,
  abstract     = {{<p>Background: Dietary pattern analysis has gained particular interest, because it reflects the complexity of dietary intake. The aim of this study was to explore the associations between a posteriori dietary patterns, derived using a data-driven approach, and the risk of differentiated thyroid cancer (TC) in Europe. Methods: This investigation included 450,064 adults from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Dietary intake was assessed using validated country-specific dietary questionnaires. A posteriori dietary patterns were computed using principal component analyses. Cox regression was used to calculate multivariable adjusted hazard ratios (HRs) and 95% confidence intervals (CIs). Results: After a mean follow-up time of 14 years, 712 first differentiated TCs were diagnosed. In the fully adjusted model, a dietary pattern characterized by alcohol consumption (basically beer and wine) was negatively associated with differentiated TC risk (HR<sub>Q4vs.Q1</sub> = 0.75; 95% CI:0.60–0.94, P-trend = 0.005), while a dietary pattern rich in sweetened beverages was positively associated with differentiated TC risk (HR<sub>Q4vs.Q1</sub> = 1.26; 95% CI:0.99–1.61; P-trend = 0.07). The remaining 8 dietary patterns were not related to differentiated TC risk. The intake of sweetened beverages was positively associated with differentiated TC risk (HR<sub>100mL/d</sub> = 1.05; 95% CI:1.00–1.11), especially with papillary TC risk (HR<sub>100mL/d</sub> = 1.07; 95% CI:1.01–1.13). Similar results were observed with sugary and artificially sweetened beverages. Conclusions: The investigation of dietary patterns detected that the consumption of sweetened beverages was associated with a higher risk of differentiated thyroid cancer. Our results are in line with the general dietary recommendations of reducing the consumption of sweetened beverages.</p>}},
  author       = {{Zamora-Ros, Raul and Cayssials, Valerie and Clèries, Ramon and Torrents, Maria and Byrnes, Graham and Weiderpass, Elisabete and Sandström, Maria and Almquist, Martin and Boutron-Ruault, Marie Christine and Tjønneland, Anne and Kyrø, Cecilie and Katzke, Verena A. and Le Cornet, Charlotte and Masala, Giovanna and Krogh, Vittorio and Iannuzzo, Gabriella and Tumino, Rosario and Milani, Lorenzo and Skeie, Guri and Ubago-Guisado, Esther and Amiano, Pilar and Chirlaque, María Dolores and Ardanaz, Eva and Janzi, Suzanne and Eriksson, Linda and Freisling, Heinz and Heath, Alicia K. and Rinaldi, Sabina and Agudo, Antonio}},
  issn         = {{1436-6207}},
  keywords     = {{Dietary pattern; EPIC; Intake; Sweetened beverages; Thyroid cancer}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{105--114}},
  publisher    = {{Springer}},
  series       = {{European Journal of Nutrition}},
  title        = {{Sweetened beverages are associated with a higher risk of differentiated thyroid cancer in the EPIC cohort : a dietary pattern approach}},
  url          = {{http://dx.doi.org/10.1007/s00394-022-02953-5}},
  doi          = {{10.1007/s00394-022-02953-5}},
  volume       = {{62}},
  year         = {{2023}},
}