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Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition

Yammine, S. G. ; Huybrechts, I. ; Biessy, C. ; Dossus, L. ; Panico, S. ; Sánchez, M. J. ; Benetou, V. ; Turzanski-Fortner, R. ; Katzke, V. and Idahl, A. , et al. (2023) In BMC Cancer 23(1).
Abstract

Background: Diet may impact important risk factors for endometrial cancer such as obesity and inflammation. However, evidence on the role of specific dietary factors is limited. We investigated associations between dietary fatty acids and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: This analysis includes 1,886 incident endometrial cancer cases and 297,432 non-cases. All participants were followed up for a mean of 8.8 years. Multivariable Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) of endometrial cancer across quintiles of individual fatty acids estimated from various food sources quantified through food... (More)

Background: Diet may impact important risk factors for endometrial cancer such as obesity and inflammation. However, evidence on the role of specific dietary factors is limited. We investigated associations between dietary fatty acids and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: This analysis includes 1,886 incident endometrial cancer cases and 297,432 non-cases. All participants were followed up for a mean of 8.8 years. Multivariable Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) of endometrial cancer across quintiles of individual fatty acids estimated from various food sources quantified through food frequency questionnaires in the entire EPIC cohort. The false discovery rate (q-values) was computed to control for multiple comparisons. Results: Consumption of n-6 γ-linolenic acid was inversely associated with endometrial cancer risk (HR comparing 5th with 1st quintileQ5−Q1=0.77, 95% CI = 0.64; 0.92, ptrend=0.01, q-value = 0.15). This association was mainly driven by γ-linolenic acid derived from plant sources (HRper unit increment=0.94, 95%CI= (0.90;0.98), p = 0.01) but not from animal sources (HRper unit increment= 1.00, 95%CI = (0.92; 1.07), p = 0.92). In addition, an inverse association was found between consumption of n-3 α-linolenic acid from vegetable sources and endometrial cancer risk (HRper unit increment= 0.93, 95%CI = (0.87; 0.99), p = 0.04). No significant association was found between any other fatty acids (individual or grouped) and endometrial cancer risk. Conclusion: Our results suggest that higher consumption of γ-linolenic acid and α-linoleic acid from plant sources may be associated with lower risk of endometrial cancer.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Diet, Endometrial cancer, Epidemiology, Fatty acids
in
BMC Cancer
volume
23
issue
1
article number
159
publisher
BioMed Central (BMC)
external identifiers
  • pmid:36797668
  • scopus:85148260026
ISSN
1471-2407
DOI
10.1186/s12885-023-10611-0
language
English
LU publication?
yes
id
81aafa9f-cdc8-4c7c-b022-1cc2c30ea7c4
date added to LUP
2023-03-02 12:02:42
date last changed
2024-06-14 00:20:02
@article{81aafa9f-cdc8-4c7c-b022-1cc2c30ea7c4,
  abstract     = {{<p>Background: Diet may impact important risk factors for endometrial cancer such as obesity and inflammation. However, evidence on the role of specific dietary factors is limited. We investigated associations between dietary fatty acids and endometrial cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Methods: This analysis includes 1,886 incident endometrial cancer cases and 297,432 non-cases. All participants were followed up for a mean of 8.8 years. Multivariable Cox proportional hazard models were used to estimate hazard ratios (HR) and 95% confidence intervals (CI) of endometrial cancer across quintiles of individual fatty acids estimated from various food sources quantified through food frequency questionnaires in the entire EPIC cohort. The false discovery rate (q-values) was computed to control for multiple comparisons. Results: Consumption of n-6 γ-linolenic acid was inversely associated with endometrial cancer risk (HR comparing 5th with 1st quintile<sub>Q5−Q1</sub>=0.77, 95% CI = 0.64; 0.92, p<sub>trend</sub>=0.01, q-value = 0.15). This association was mainly driven by γ-linolenic acid derived from plant sources (HR<sub>per unit increment</sub>=0.94, 95%CI= (0.90;0.98), p = 0.01) but not from animal sources (HR<sub>per unit increment</sub>= 1.00, 95%CI = (0.92; 1.07), p = 0.92). In addition, an inverse association was found between consumption of n-3 α-linolenic acid from vegetable sources and endometrial cancer risk (HR<sub>per unit increment</sub>= 0.93, 95%CI = (0.87; 0.99), p = 0.04). No significant association was found between any other fatty acids (individual or grouped) and endometrial cancer risk. Conclusion: Our results suggest that higher consumption of γ-linolenic acid and α-linoleic acid from plant sources may be associated with lower risk of endometrial cancer.</p>}},
  author       = {{Yammine, S. G. and Huybrechts, I. and Biessy, C. and Dossus, L. and Panico, S. and Sánchez, M. J. and Benetou, V. and Turzanski-Fortner, R. and Katzke, V. and Idahl, A. and Skeie, G. and Olsen, K. Standahl and Tjønneland, A. and Halkjaer, J. and Colorado-Yohar, S. and Heath, A. K. and Sonestedt, E. and Sartor, H. and Schulze, M. B. and Palli, D. and Crous-Bou, M. and Dorronsoro, A. and Overvad, K. and Gurrea, A. Barricarte and Severi, G. and Vermeulen, R. C.H. and Sandanger, T. M. and Travis, R. C. and Key, T. and Amiano, P. and Van Guelpen, B. and Johansson, M. and Sund, M. and Tumino, R. and Wareham, N. and Sacerdote, C. and Krogh, V. and Brennan, P. and Riboli, E. and Weiderpass, E. and Gunter, M. J. and Chajès, V.}},
  issn         = {{1471-2407}},
  keywords     = {{Diet; Endometrial cancer; Epidemiology; Fatty acids}},
  language     = {{eng}},
  number       = {{1}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{BMC Cancer}},
  title        = {{Dietary fatty acids and endometrial cancer risk within the European Prospective Investigation into Cancer and Nutrition}},
  url          = {{http://dx.doi.org/10.1186/s12885-023-10611-0}},
  doi          = {{10.1186/s12885-023-10611-0}},
  volume       = {{23}},
  year         = {{2023}},
}