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Pre-diagnostic polyphenol intake and breast cancer survival: the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.

Kyrø, Cecilie; Zamora-Ros, Raul; Scalbert, Augustin; Tjønneland, Anne; Dossus, Laure; Johansen, Christoffer; Bidstrup, Pernille Envold; Weiderpass, Elisabete; Christensen, Jane and Ward, Heather, et al. (2015) In Breast Cancer Research and Treatment 154(2). p.389-401
Abstract
The aim was to investigate the association between pre-diagnostic intakes of polyphenol classes (flavonoids, lignans, phenolic acids, stilbenes, and other polyphenols) in relation to breast cancer survival (all-cause and breast cancer-specific mortality). We used data from the European Prospective Investigation into Cancer and Nutrition cohort. Pre-diagnostic usual diet was assessed using dietary questionnaires, and polyphenol intakes were estimated using the Phenol-Explorer database. We followed 11,782 breast cancer cases from time of diagnosis until death, end of follow-up or last day of contact. During a median of 6 years, 1482 women died (753 of breast cancer). We related polyphenol intake to all-cause and breast cancer-specific... (More)
The aim was to investigate the association between pre-diagnostic intakes of polyphenol classes (flavonoids, lignans, phenolic acids, stilbenes, and other polyphenols) in relation to breast cancer survival (all-cause and breast cancer-specific mortality). We used data from the European Prospective Investigation into Cancer and Nutrition cohort. Pre-diagnostic usual diet was assessed using dietary questionnaires, and polyphenol intakes were estimated using the Phenol-Explorer database. We followed 11,782 breast cancer cases from time of diagnosis until death, end of follow-up or last day of contact. During a median of 6 years, 1482 women died (753 of breast cancer). We related polyphenol intake to all-cause and breast cancer-specific mortality using Cox proportional hazard models with time since diagnosis as underlying time and strata for age and country. Among postmenopausal women, an intake of lignans in the highest versus lowest quartile was related to a 28 % lower risk of dying from breast (adjusted model: HR, quartile 4 vs. quartile 1, 0.72, 95 % CI 0.53; 0.98). In contrast, in premenopausal women, a positive association between lignan intake and all-cause mortality was found (adjusted model: HR, quartile 4 vs. quartile 1, 1.63, 95 % CI 1.03; 2.57). We found no association for other polyphenol classes. Intake of lignans before breast cancer diagnosis may be related to improved survival among postmenopausal women, but may on the contrary worsen the survival for premenopausal women. This suggests that the role of phytoestrogens in breast cancer survival is complex and may be dependent of menopausal status. (Less)
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Breast Cancer Research and Treatment
volume
154
issue
2
pages
389 - 401
publisher
Springer
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  • pmid:26531755
  • wos:000365188600017
  • scopus:84947493327
ISSN
1573-7217
DOI
10.1007/s10549-015-3595-9
language
English
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9deb0843-876c-4400-a501-beacfb43fb8a (old id 8243318)
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http://www.ncbi.nlm.nih.gov/pubmed/26531755?dopt=Abstract
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2015-12-02 19:14:58
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2017-11-12 03:05:26
@article{9deb0843-876c-4400-a501-beacfb43fb8a,
  abstract     = {The aim was to investigate the association between pre-diagnostic intakes of polyphenol classes (flavonoids, lignans, phenolic acids, stilbenes, and other polyphenols) in relation to breast cancer survival (all-cause and breast cancer-specific mortality). We used data from the European Prospective Investigation into Cancer and Nutrition cohort. Pre-diagnostic usual diet was assessed using dietary questionnaires, and polyphenol intakes were estimated using the Phenol-Explorer database. We followed 11,782 breast cancer cases from time of diagnosis until death, end of follow-up or last day of contact. During a median of 6 years, 1482 women died (753 of breast cancer). We related polyphenol intake to all-cause and breast cancer-specific mortality using Cox proportional hazard models with time since diagnosis as underlying time and strata for age and country. Among postmenopausal women, an intake of lignans in the highest versus lowest quartile was related to a 28 % lower risk of dying from breast (adjusted model: HR, quartile 4 vs. quartile 1, 0.72, 95 % CI 0.53; 0.98). In contrast, in premenopausal women, a positive association between lignan intake and all-cause mortality was found (adjusted model: HR, quartile 4 vs. quartile 1, 1.63, 95 % CI 1.03; 2.57). We found no association for other polyphenol classes. Intake of lignans before breast cancer diagnosis may be related to improved survival among postmenopausal women, but may on the contrary worsen the survival for premenopausal women. This suggests that the role of phytoestrogens in breast cancer survival is complex and may be dependent of menopausal status.},
  author       = {Kyrø, Cecilie and Zamora-Ros, Raul and Scalbert, Augustin and Tjønneland, Anne and Dossus, Laure and Johansen, Christoffer and Bidstrup, Pernille Envold and Weiderpass, Elisabete and Christensen, Jane and Ward, Heather and Aune, Dagfinn and Riboli, Elio and His, Mathilde and Clavel-Chapelon, Françoise and Baglietto, Laura and Katzke, Verena and Kühn, Tilman and Boeing, Heiner and Floegel, Anna and Overvad, Kim and Lasheras, Cristina and Travier, Noémie and Sánchez, Maria-José and Amiano, Pilar and Chirlaque, Maria-Dolores and Ardanaz, Eva and Khaw, Kay-Tee and Wareham, Nick and Perez-Cornago, Aurora and Trichopoulou, Antonia and Lagiou, Pagona and Vasilopoulou, Effie and Masala, Giovanna and Grioni, Sara and Berrino, Franco and Tumino, Rosario and Sacerdote, Carlotta and Mattiello, Amalia and Bueno-de-Mesquita, H B As and Peeters, Petra H and van Gils, Carla and Borgquist, Signe and Butt, Salma and Zeleniuch-Jacquotte, Anne and Sund, Malin and Hjartåker, Anette and Skeie, Guri and Olsen, Anja and Romieu, Isabelle},
  issn         = {1573-7217},
  language     = {eng},
  number       = {2},
  pages        = {389--401},
  publisher    = {Springer},
  series       = {Breast Cancer Research and Treatment},
  title        = {Pre-diagnostic polyphenol intake and breast cancer survival: the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.},
  url          = {http://dx.doi.org/10.1007/s10549-015-3595-9},
  volume       = {154},
  year         = {2015},
}