Food sources of fat and sex hormone receptor status of invasive breast tumors in women of the malmö diet and cancer cohort.
Wirfält, Elisabet LU ; Li, Cairu LU ; Manjer, Jonas LU ; Ericson, Ulrika LU ; Sonestedt, Emily LU
; Borgquist, Signe
LU
; Landberg, Göran
LU
; Olsson, Håkan
LU
and Gullberg, Bo
LU
(2011)
In Nutrition and Cancer
63(5).
p.722-733
- Abstract
- We examined associations between food intakes and incident breast cancer, defined by estrogen receptor (ER) and progesterone receptor (PR) status in the Malmö Diet and Cancer cohort (17,000 women aged 45-73 yr). The hazard ratios (HRs) of ER+PR+ (n = 270), ER+PR- (n = 87), and ER-PR- (n = 61) tumors and all cancer (n = 544) were estimated after 10 yr of follow-up. In multivariate analysis of ER+PR+ tumors, a protective linear risk trend, indicating change between adjoining food categories, was seen with yogurt (HR = 0.89, 95% CI = 0.80-0.99), but increased risks with eggs (HR = 1.10, 95% CI = 1.01-1.20) and dried soups/sauces (HR = 1.10, 95% CI = 1.00-1.22). In ER-PR- tumors, vegetable-oil-based margarine (HR = 1.31, 95% CI = 1.09-1.59)... (More)
- We examined associations between food intakes and incident breast cancer, defined by estrogen receptor (ER) and progesterone receptor (PR) status in the Malmö Diet and Cancer cohort (17,000 women aged 45-73 yr). The hazard ratios (HRs) of ER+PR+ (n = 270), ER+PR- (n = 87), and ER-PR- (n = 61) tumors and all cancer (n = 544) were estimated after 10 yr of follow-up. In multivariate analysis of ER+PR+ tumors, a protective linear risk trend, indicating change between adjoining food categories, was seen with yogurt (HR = 0.89, 95% CI = 0.80-0.99), but increased risks with eggs (HR = 1.10, 95% CI = 1.01-1.20) and dried soups/sauces (HR = 1.10, 95% CI = 1.00-1.22). In ER-PR- tumors, vegetable-oil-based margarine (HR = 1.31, 95% CI = 1.09-1.59) and dried soups/sauces (HR = 1.31 95% CI = 1.05-1.64) showed increased risks. Heterogeneity was observed between ER+PR+ and ER-PR- tumors for vegetable-oil-based margarine (P < 0.01). Regular milk showed decreased, and dried soups/sauces increased, risk with all breast cancer. The study suggests that fat-containing food may contribute both to hormonal and nonhormonal mechanisms in breast tumor development and supports observations of positive associations between characteristics of Westernized diets and postmenopausal breast cancer. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/2058541
- author
- Wirfält, Elisabet
LU
; Li, Cairu
LU
; Manjer, Jonas
LU
; Ericson, Ulrika
LU
; Sonestedt, Emily
LU
; Borgquist, Signe
LU
; Landberg, Göran
LU
; Olsson, Håkan
LU
and Gullberg, Bo
LU
- organization
-
- Nutrition Epidemiology (research group)
- Cardiovascular Research - Epidemiology (research group)
- Surgery (research group)
- Diabetes - Cardiovascular Disease (research group)
- Pathology, Malmö (research group)
- Breastcancer-genetics
- EXODIAB: Excellence of Diabetes Research in Sweden
- EpiHealth: Epidemiology for Health
- BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
- publishing date
- 2011
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nutrition and Cancer
- volume
- 63
- issue
- 5
- pages
- 722 - 733
- publisher
- Lawrence Erlbaum Associates
- external identifiers
-
- wos:000294370900007
- pmid:21767080
- scopus:79960581907
- pmid:21767080
- ISSN
- 1532-7914
- DOI
- 10.1080/01635581.2011.570897
- language
- English
- LU publication?
- yes
- id
- 844b5f64-f586-48d9-9e11-931535160c52 (old id 2058541)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/21767080?dopt=Abstract
- date added to LUP
- 2016-04-04 07:13:04
- date last changed
- 2022-02-20 20:08:39
@article{844b5f64-f586-48d9-9e11-931535160c52,
abstract = {{We examined associations between food intakes and incident breast cancer, defined by estrogen receptor (ER) and progesterone receptor (PR) status in the Malmö Diet and Cancer cohort (17,000 women aged 45-73 yr). The hazard ratios (HRs) of ER+PR+ (n = 270), ER+PR- (n = 87), and ER-PR- (n = 61) tumors and all cancer (n = 544) were estimated after 10 yr of follow-up. In multivariate analysis of ER+PR+ tumors, a protective linear risk trend, indicating change between adjoining food categories, was seen with yogurt (HR = 0.89, 95% CI = 0.80-0.99), but increased risks with eggs (HR = 1.10, 95% CI = 1.01-1.20) and dried soups/sauces (HR = 1.10, 95% CI = 1.00-1.22). In ER-PR- tumors, vegetable-oil-based margarine (HR = 1.31, 95% CI = 1.09-1.59) and dried soups/sauces (HR = 1.31 95% CI = 1.05-1.64) showed increased risks. Heterogeneity was observed between ER+PR+ and ER-PR- tumors for vegetable-oil-based margarine (P < 0.01). Regular milk showed decreased, and dried soups/sauces increased, risk with all breast cancer. The study suggests that fat-containing food may contribute both to hormonal and nonhormonal mechanisms in breast tumor development and supports observations of positive associations between characteristics of Westernized diets and postmenopausal breast cancer.}},
author = {{Wirfält, Elisabet and Li, Cairu and Manjer, Jonas and Ericson, Ulrika and Sonestedt, Emily and Borgquist, Signe and Landberg, Göran and Olsson, Håkan and Gullberg, Bo}},
issn = {{1532-7914}},
language = {{eng}},
number = {{5}},
pages = {{722--733}},
publisher = {{Lawrence Erlbaum Associates}},
series = {{Nutrition and Cancer}},
title = {{Food sources of fat and sex hormone receptor status of invasive breast tumors in women of the malmö diet and cancer cohort.}},
url = {{http://dx.doi.org/10.1080/01635581.2011.570897}},
doi = {{10.1080/01635581.2011.570897}},
volume = {{63}},
year = {{2011}},
}