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Pyridoxine reduces cholesterol and low-density lipoprotein and increases antithrombin III activity in 80-year-old men with low plasma pyridoxal 5-phosphate

Brattström, L ; Stavenow, L. ; Galvard, H LU ; Nilsson-Ehle, P LU ; Berntorp, E LU ; Jerntorp, P ; Elmståhl, S LU and Pessah-Rasmussen, H LU (1990) In Scandinavian Journal of Clinical & Laboratory Investigation 50(8). p.873-877
Abstract

We have previously observed that pyridoxine treatment reduced plasma total cholesterol (TC) and low-density lipoprotein (LDL) cholesterol concentrations and increased antithrombin III (AT III) activity in atherosclerotic patients with subnormal plasma pyridoxal 5-phosphate (PLP) levels. In order to confirm these results, we selected 17 males with low plasma PLP levels from a group of 122 80-year-old males in whom PLP has been determined. After supplementation with 120 mg of pyridoxine per day for 8 weeks their mean plasma TC and LDL cholesterol concentrations were decreased by 10% (p less than 0.01) and 17% (p less than 0.001), respectively. There was no effect on high-density lipoprotein cholesterol and triglycerides but plasma AT III... (More)

We have previously observed that pyridoxine treatment reduced plasma total cholesterol (TC) and low-density lipoprotein (LDL) cholesterol concentrations and increased antithrombin III (AT III) activity in atherosclerotic patients with subnormal plasma pyridoxal 5-phosphate (PLP) levels. In order to confirm these results, we selected 17 males with low plasma PLP levels from a group of 122 80-year-old males in whom PLP has been determined. After supplementation with 120 mg of pyridoxine per day for 8 weeks their mean plasma TC and LDL cholesterol concentrations were decreased by 10% (p less than 0.01) and 17% (p less than 0.001), respectively. There was no effect on high-density lipoprotein cholesterol and triglycerides but plasma AT III activity was increased by 6% (p less than 0.05). The mechanism by which pyridoxine acts is unclear but it is hypothesized that pyridoxine-derived PLP may enhance the catabolism of LDL and the activity of AT III by inhibiting their glycosylation.

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author
; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cholesterol, pyridoxal 5-phosphate, antithrombin III, pyridoxine, low-density lipoproteins
in
Scandinavian Journal of Clinical & Laboratory Investigation
volume
50
issue
8
pages
5 pages
publisher
Informa Healthcare
external identifiers
  • pmid:2084825
  • scopus:0025650379
  • pmid:2084825
ISSN
1502-7686
DOI
10.3109/00365519009104955
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neurology, Malmö (013027010), Division of Geriatric Medicine (013040040), Clinical Coagulation Research Unit (013242510), Division of Clinical Chemistry and Pharmacology (013250300)
id
92f022b1-5493-46fc-b109-f9ff0c57dbab (old id 1105453)
date added to LUP
2016-04-01 16:18:27
date last changed
2021-01-03 06:15:29
@article{92f022b1-5493-46fc-b109-f9ff0c57dbab,
  abstract     = {{<p>We have previously observed that pyridoxine treatment reduced plasma total cholesterol (TC) and low-density lipoprotein (LDL) cholesterol concentrations and increased antithrombin III (AT III) activity in atherosclerotic patients with subnormal plasma pyridoxal 5-phosphate (PLP) levels. In order to confirm these results, we selected 17 males with low plasma PLP levels from a group of 122 80-year-old males in whom PLP has been determined. After supplementation with 120 mg of pyridoxine per day for 8 weeks their mean plasma TC and LDL cholesterol concentrations were decreased by 10% (p less than 0.01) and 17% (p less than 0.001), respectively. There was no effect on high-density lipoprotein cholesterol and triglycerides but plasma AT III activity was increased by 6% (p less than 0.05). The mechanism by which pyridoxine acts is unclear but it is hypothesized that pyridoxine-derived PLP may enhance the catabolism of LDL and the activity of AT III by inhibiting their glycosylation.</p>}},
  author       = {{Brattström, L and Stavenow, L. and Galvard, H and Nilsson-Ehle, P and Berntorp, E and Jerntorp, P and Elmståhl, S and Pessah-Rasmussen, H}},
  issn         = {{1502-7686}},
  keywords     = {{cholesterol; pyridoxal 5-phosphate; antithrombin III; pyridoxine; low-density lipoproteins}},
  language     = {{eng}},
  number       = {{8}},
  pages        = {{873--877}},
  publisher    = {{Informa Healthcare}},
  series       = {{Scandinavian Journal of Clinical & Laboratory Investigation}},
  title        = {{Pyridoxine reduces cholesterol and low-density lipoprotein and increases antithrombin III activity in 80-year-old men with low plasma pyridoxal 5-phosphate}},
  url          = {{http://dx.doi.org/10.3109/00365519009104955}},
  doi          = {{10.3109/00365519009104955}},
  volume       = {{50}},
  year         = {{1990}},
}