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Supplementation by thylakoids to a high carbohydrate meal decreases feelings of hunger, elevates CCK levels and prevents postprandial hypoglycaemia in overweight women.

Stenblom, Eva-Lena LU ; Montelius, Caroline LU ; Östbring, Karolina LU ; Håkansson, Maria LU ; Nilsson, Sofia; Rehfeld, Jens F and Erlanson-Albertsson, Charlotte LU (2013) In Appetite 68. p.118-123
Abstract
Thylakoids are chlorophyll-containing membranes in chloroplasts that have been isolated from green leaves. It has been previously shown that thylakoids supplemented with a high-fat meal can affect cholecystokinin (CCK), ghrelin, insulin and blood lipids in humans, and can act to suppress food intake and prevent body weight gain in rodents. This study investigates the addition of thylakoids to a high carbohydrate meal and its effects upon hunger motivation and fullness, and the levels of glucose, insulin, CCK, ghrelin and tumour necrosis factor (TNF)-alpha in overweight women. Twenty moderately overweight female subjects received test meals on three different occasions; two thylakoid enriched and one control, separated by 1week. The test... (More)
Thylakoids are chlorophyll-containing membranes in chloroplasts that have been isolated from green leaves. It has been previously shown that thylakoids supplemented with a high-fat meal can affect cholecystokinin (CCK), ghrelin, insulin and blood lipids in humans, and can act to suppress food intake and prevent body weight gain in rodents. This study investigates the addition of thylakoids to a high carbohydrate meal and its effects upon hunger motivation and fullness, and the levels of glucose, insulin, CCK, ghrelin and tumour necrosis factor (TNF)-alpha in overweight women. Twenty moderately overweight female subjects received test meals on three different occasions; two thylakoid enriched and one control, separated by 1week. The test meals consisted of a high carbohydrate Swedish breakfast, with or without addition of thylakoids. Blood samples and VAS-questionnaires were evaluated over a 4-h period. Addition of thylakoids suppressed hunger motivation and increased secretion of CCK from 180min, and prevented postprandial hypoglycaemia from 90min following food intake. These effects indicate that thylakoids may intensify signals of satiety. This study therefore suggests that the dietary addition of thylakoids could aid efforts to reduce food intake and prevent compensational eating later in the day, which may help to reduce body weight over time. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Appetite
volume
68
pages
118 - 123
publisher
Elsevier
external identifiers
  • wos:000321469900018
  • pmid:23632035
  • scopus:84878244368
ISSN
1095-8304
DOI
10.1016/j.appet.2013.04.022
language
English
LU publication?
yes
id
940ce2e0-5d85-40fb-b0cc-e24de2040848 (old id 3805121)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23632035?dopt=Abstract
date added to LUP
2013-06-03 16:03:28
date last changed
2019-02-20 01:16:10
@article{940ce2e0-5d85-40fb-b0cc-e24de2040848,
  abstract     = {Thylakoids are chlorophyll-containing membranes in chloroplasts that have been isolated from green leaves. It has been previously shown that thylakoids supplemented with a high-fat meal can affect cholecystokinin (CCK), ghrelin, insulin and blood lipids in humans, and can act to suppress food intake and prevent body weight gain in rodents. This study investigates the addition of thylakoids to a high carbohydrate meal and its effects upon hunger motivation and fullness, and the levels of glucose, insulin, CCK, ghrelin and tumour necrosis factor (TNF)-alpha in overweight women. Twenty moderately overweight female subjects received test meals on three different occasions; two thylakoid enriched and one control, separated by 1week. The test meals consisted of a high carbohydrate Swedish breakfast, with or without addition of thylakoids. Blood samples and VAS-questionnaires were evaluated over a 4-h period. Addition of thylakoids suppressed hunger motivation and increased secretion of CCK from 180min, and prevented postprandial hypoglycaemia from 90min following food intake. These effects indicate that thylakoids may intensify signals of satiety. This study therefore suggests that the dietary addition of thylakoids could aid efforts to reduce food intake and prevent compensational eating later in the day, which may help to reduce body weight over time.},
  author       = {Stenblom, Eva-Lena and Montelius, Caroline and Östbring, Karolina and Håkansson, Maria and Nilsson, Sofia and Rehfeld, Jens F and Erlanson-Albertsson, Charlotte},
  issn         = {1095-8304},
  language     = {eng},
  pages        = {118--123},
  publisher    = {Elsevier},
  series       = {Appetite},
  title        = {Supplementation by thylakoids to a high carbohydrate meal decreases feelings of hunger, elevates CCK levels and prevents postprandial hypoglycaemia in overweight women.},
  url          = {http://dx.doi.org/10.1016/j.appet.2013.04.022},
  volume       = {68},
  year         = {2013},
}