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The assessment of serum-mediated phagocytosis of necrotic material by polymorphonuclear leukocytes to diagnose and predict the clinical features of systemic lupus erythematosus: an observational longitudinal study

Compagno, Michele LU ; Gullstrand, Birgitta LU ; Jacobsen, Sören ; Eilertsen, Gro Ö ; Nilsson, Jan-Åke LU ; Lood, Christian LU ; Jönsen, Andreas LU ; Truedsson, Lennart LU ; Sturfelt, Gunnar LU and Bengtsson, Anders LU (2016) In Arthritis Research and Therapy 18.
Abstract
Serum-mediated phagocytosis of antibody- and complement-opsonized necrotic cell material (NCM) by polymorphonuclear leukocytes can be quantified by using a flow cytometry–based assay. The phagocytosis of necrotic cell material (PNC) assay parallels the well-known lupus erythematosus cell test. In this study, we aimed to investigate the diagnostic accuracy of the assay and the relationship with clinical manifestations and disease activity in systemic lupus erythematosus (SLE).
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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Systemic lupus erythematosus, Biomarkers, Diagnostic accuracy, Flow cytometry, Disease activity, Lupus nephritis
in
Arthritis Research and Therapy
volume
18
article number
44
publisher
BioMed Central (BMC)
external identifiers
  • pmid:26860519
  • scopus:84957597981
  • wos:000370007800001
  • pmid:26860519
ISSN
1478-6362
DOI
10.1186/s13075-016-0941-1
language
English
LU publication?
yes
id
a00e4d92-6598-4179-aeab-282153c8e975 (old id 8626609)
date added to LUP
2016-04-01 10:51:45
date last changed
2024-05-20 01:43:24
@article{a00e4d92-6598-4179-aeab-282153c8e975,
  abstract     = {{Serum-mediated phagocytosis of antibody- and complement-opsonized necrotic cell material (NCM) by polymorphonuclear leukocytes can be quantified by using a flow cytometry–based assay. The phagocytosis of necrotic cell material (PNC) assay parallels the well-known lupus erythematosus cell test. In this study, we aimed to investigate the diagnostic accuracy of the assay and the relationship with clinical manifestations and disease activity in systemic lupus erythematosus (SLE).}},
  author       = {{Compagno, Michele and Gullstrand, Birgitta and Jacobsen, Sören and Eilertsen, Gro Ö and Nilsson, Jan-Åke and Lood, Christian and Jönsen, Andreas and Truedsson, Lennart and Sturfelt, Gunnar and Bengtsson, Anders}},
  issn         = {{1478-6362}},
  keywords     = {{Systemic lupus erythematosus; Biomarkers; Diagnostic accuracy; Flow cytometry; Disease activity; Lupus nephritis}},
  language     = {{eng}},
  publisher    = {{BioMed Central (BMC)}},
  series       = {{Arthritis Research and Therapy}},
  title        = {{The assessment of serum-mediated phagocytosis of necrotic material by polymorphonuclear leukocytes to diagnose and predict the clinical features of systemic lupus erythematosus: an observational longitudinal study}},
  url          = {{https://lup.lub.lu.se/search/files/2193347/8627524}},
  doi          = {{10.1186/s13075-016-0941-1}},
  volume       = {{18}},
  year         = {{2016}},
}