Citrus intake and risk of skin cancer in the European Prospective Investigation into Cancer and Nutrition cohort (EPIC)
(2020) In European Journal of Epidemiology 35(11). p.1057-1067- Abstract
Citrus intake has been suggested to increase the risk of skin cancer. Although this relation is highly plausible biologically, epidemiologic evidence is lacking. We aimed to examine the potential association between citrus intake and skin cancer risk. EPIC is an ongoing multi-center prospective cohort initiated in 1992 and involving ~ 520,000 participants who have been followed-up in 23 centers from 10 European countries. Dietary data were collected at baseline using validated country-specific dietary questionnaires. We used Cox proportional hazards regression models to compute hazard ratios (HR) and 95% confidence intervals (CI). During a mean follow-up of 13.7 years, 8448 skin cancer cases were identified among 270,112 participants.... (More)
Citrus intake has been suggested to increase the risk of skin cancer. Although this relation is highly plausible biologically, epidemiologic evidence is lacking. We aimed to examine the potential association between citrus intake and skin cancer risk. EPIC is an ongoing multi-center prospective cohort initiated in 1992 and involving ~ 520,000 participants who have been followed-up in 23 centers from 10 European countries. Dietary data were collected at baseline using validated country-specific dietary questionnaires. We used Cox proportional hazards regression models to compute hazard ratios (HR) and 95% confidence intervals (CI). During a mean follow-up of 13.7 years, 8448 skin cancer cases were identified among 270,112 participants. We observed a positive linear dose–response relationship between total citrus intake and skin cancer risk (HR = 1.10, 95% CI 1.03–1.18 in the highest vs. lowest quartile; Ptrend = 0.001), particularly with basal cell carcinoma (BCC) (HR = 1.11, 95% CI 1.02–1.20, Ptrend = 0.007) and squamous cell carcinoma (SCC) (HR = 1.23, 95% CI 1.04–1.47, Ptrend = 0.01). Citrus fruit intake was positively associated with skin cancer risk (HR = 1.08, 95% CI 1.01–1.16, Ptrend = 0.01), particularly with melanoma (HR = 1.23, 95% CI 1.02–1.48; Ptrend = 0.01), although with no heterogeneity across skin cancer types (Phomogeneity = 0.21). Citrus juice was positively associated with skin cancer risk (Ptrend = 0.004), particularly with BCC (Ptrend = 0.008) and SCC (Ptrend = 0.004), but not with melanoma (Phomogeneity = 0.02). Our study suggests moderate positive linear dose–response relationships between citrus intake and skin cancer risk. Studies with available biomarker data and the ability to examine sun exposure behaviors are warranted to clarify these associations and examine the phototoxicity mechanisms of furocoumarin-rich foods.
(Less)
- author
- Mahamat-Saleh, Yahya
; Cervenka, Iris
; Al-Rahmoun, Marie
; Mancini, Francesca R.
; Severi, Gianluca
; Ghiasvand, Reza
; Veierod, Marit B.
; Caini, Saverio
; Palli, Domenico
; Botteri, Edoardo
; Sacerdote, Carlotta
; Ricceri, Fulvio
; Trichopoulou, Antonia
; Peppa, Eleni
; La Vecchia, Carlo
; Overvad, Kim
; Dahm, Christina C.
; Olsen, Anja
; Tjønneland, Anne
; Perez-Cornago, Aurora
; Jakszyn, Paula
; Grioni, Sara
; Schulze, Matthias B.
; Skeie, Guri
; Lasheras, Cristina
; Colorado-Yohar, Sandra
; Rodríguez-Barranco, Miguel
; Kühn, Tilman
; Katzke, Verena A.
; Amiano, Pilar
; Tumino, Rosario
; Panico, Salvatore
; Ezponda, Ana
; Sonestedt, Emily
LU
; Scalbert, Augustin
; Weiderpass, Elisabete
; Boutron-Ruault, Marie Christine
and Kvaskoff, Marina
(Less) - organization
- publishing date
- 2020-11
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Citrus, Cohort studies, Cutaneous melanoma, Epidemiology, Keratinocyte cancers
- in
- European Journal of Epidemiology
- volume
- 35
- issue
- 11
- pages
- 11 pages
- publisher
- Springer
- external identifiers
-
- pmid:32710289
- scopus:85088559805
- ISSN
- 0393-2990
- DOI
- 10.1007/s10654-020-00666-9
- language
- English
- LU publication?
- yes
- id
- a5cf8076-141e-47f6-921e-ade56347cb2e
- date added to LUP
- 2020-08-06 13:03:34
- date last changed
- 2024-03-20 13:50:31
@article{a5cf8076-141e-47f6-921e-ade56347cb2e,
abstract = {{<p>Citrus intake has been suggested to increase the risk of skin cancer. Although this relation is highly plausible biologically, epidemiologic evidence is lacking. We aimed to examine the potential association between citrus intake and skin cancer risk. EPIC is an ongoing multi-center prospective cohort initiated in 1992 and involving ~ 520,000 participants who have been followed-up in 23 centers from 10 European countries. Dietary data were collected at baseline using validated country-specific dietary questionnaires. We used Cox proportional hazards regression models to compute hazard ratios (HR) and 95% confidence intervals (CI). During a mean follow-up of 13.7 years, 8448 skin cancer cases were identified among 270,112 participants. We observed a positive linear dose–response relationship between total citrus intake and skin cancer risk (HR = 1.10, 95% CI 1.03–1.18 in the highest vs. lowest quartile; P<sub>trend</sub> = 0.001), particularly with basal cell carcinoma (BCC) (HR = 1.11, 95% CI 1.02–1.20, P<sub>trend</sub> = 0.007) and squamous cell carcinoma (SCC) (HR = 1.23, 95% CI 1.04–1.47, P<sub>trend</sub> = 0.01). Citrus fruit intake was positively associated with skin cancer risk (HR = 1.08, 95% CI 1.01–1.16, P<sub>trend</sub> = 0.01), particularly with melanoma (HR = 1.23, 95% CI 1.02–1.48; P<sub>trend</sub> = 0.01), although with no heterogeneity across skin cancer types (P<sub>homogeneity</sub> = 0.21). Citrus juice was positively associated with skin cancer risk (P<sub>trend</sub> = 0.004), particularly with BCC (P<sub>trend</sub> = 0.008) and SCC (P<sub>trend</sub> = 0.004), but not with melanoma (P<sub>homogeneity</sub> = 0.02). Our study suggests moderate positive linear dose–response relationships between citrus intake and skin cancer risk. Studies with available biomarker data and the ability to examine sun exposure behaviors are warranted to clarify these associations and examine the phototoxicity mechanisms of furocoumarin-rich foods.</p>}},
author = {{Mahamat-Saleh, Yahya and Cervenka, Iris and Al-Rahmoun, Marie and Mancini, Francesca R. and Severi, Gianluca and Ghiasvand, Reza and Veierod, Marit B. and Caini, Saverio and Palli, Domenico and Botteri, Edoardo and Sacerdote, Carlotta and Ricceri, Fulvio and Trichopoulou, Antonia and Peppa, Eleni and La Vecchia, Carlo and Overvad, Kim and Dahm, Christina C. and Olsen, Anja and Tjønneland, Anne and Perez-Cornago, Aurora and Jakszyn, Paula and Grioni, Sara and Schulze, Matthias B. and Skeie, Guri and Lasheras, Cristina and Colorado-Yohar, Sandra and Rodríguez-Barranco, Miguel and Kühn, Tilman and Katzke, Verena A. and Amiano, Pilar and Tumino, Rosario and Panico, Salvatore and Ezponda, Ana and Sonestedt, Emily and Scalbert, Augustin and Weiderpass, Elisabete and Boutron-Ruault, Marie Christine and Kvaskoff, Marina}},
issn = {{0393-2990}},
keywords = {{Citrus; Cohort studies; Cutaneous melanoma; Epidemiology; Keratinocyte cancers}},
language = {{eng}},
number = {{11}},
pages = {{1057--1067}},
publisher = {{Springer}},
series = {{European Journal of Epidemiology}},
title = {{Citrus intake and risk of skin cancer in the European Prospective Investigation into Cancer and Nutrition cohort (EPIC)}},
url = {{http://dx.doi.org/10.1007/s10654-020-00666-9}},
doi = {{10.1007/s10654-020-00666-9}},
volume = {{35}},
year = {{2020}},
}