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Oat beta-glucans consumed at breakfast improve glucose tolerance acutely and after a subsequent lunch - a randomized dose-response study in healthy young adults

Hossain, Mohammad Mukul LU ; Tovar, Juscelino LU orcid ; Cloetens, Lieselotte LU ; Geraldi, Marina Vilar LU ; Venuti, Chiara LU and Nilsson, Anne LU (2025) In Food & Function 16(10). p.4161-4171
Abstract

Oat beta-glucans (OBGs) lower postprandial blood glucose by increasing gastrointestinal viscosity, delaying gastric emptying, and slowing glucose absorption. While the European Food Safety Authority (EFSA) recommends a minimum intake of 4 g of OBGs per 30 g of available carbohydrates (avCHO) for a significant reduction in glycaemic response, this poses formulation challenges. This study investigated the effects of a commercially available OBG ingredient on postprandial glycemia and appetite sensations immediately after ingestion and following a standardized lunch 3.5 hours later, also exploring whether doses below 4 g of OBGs per 30 g of avCHO could be effective. Nineteen healthy subjects consumed test drinks containing 0 g (Ref), 2 g... (More)

Oat beta-glucans (OBGs) lower postprandial blood glucose by increasing gastrointestinal viscosity, delaying gastric emptying, and slowing glucose absorption. While the European Food Safety Authority (EFSA) recommends a minimum intake of 4 g of OBGs per 30 g of available carbohydrates (avCHO) for a significant reduction in glycaemic response, this poses formulation challenges. This study investigated the effects of a commercially available OBG ingredient on postprandial glycemia and appetite sensations immediately after ingestion and following a standardized lunch 3.5 hours later, also exploring whether doses below 4 g of OBGs per 30 g of avCHO could be effective. Nineteen healthy subjects consumed test drinks containing 0 g (Ref), 2 g (BG2), 3 g (BG3), or 4 g (BG4) of OBGs, each providing 30 g of avCHO, in a crossover study. BG2 and BG4 reduced the incremental glucose peak (iPeak) compared to Ref (P < 0.05), with BG3 showing a trend (P = 0.09). BG4 reduced an early glucose incremental area under the curve (iAUC 0-60 min) and improved the post-lunch glycaemic response compared to Ref (P < 0.05). Insulin iPeaks and iAUC (0-120 min) were lower for BG3 and BG4 (P < 0.05). BG4 enhanced satiety and reduced hunger throughout the experimental period (P < 0.05). Doses below 4 g of OBGs per 30 g of avCHO improved postprandial glycemia and appetite, and OBG intake at breakfast enhanced post-lunch glycaemic regulation, suggesting that a lower threshold may be effective in blood glucose management and appetite control.

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organization
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type
Contribution to journal
publication status
published
subject
in
Food & Function
volume
16
issue
10
pages
11 pages
publisher
Royal Society of Chemistry
external identifiers
  • pmid:40326558
  • scopus:105004900951
  • pmid:40326558
ISSN
2042-6496
DOI
10.1039/d5fo00353a
language
English
LU publication?
yes
id
a927c7a1-4b46-44d6-a598-63243dc2ed1c
date added to LUP
2025-05-11 21:14:27
date last changed
2025-07-08 13:06:18
@article{a927c7a1-4b46-44d6-a598-63243dc2ed1c,
  abstract     = {{<p>Oat beta-glucans (OBGs) lower postprandial blood glucose by increasing gastrointestinal viscosity, delaying gastric emptying, and slowing glucose absorption. While the European Food Safety Authority (EFSA) recommends a minimum intake of 4 g of OBGs per 30 g of available carbohydrates (avCHO) for a significant reduction in glycaemic response, this poses formulation challenges. This study investigated the effects of a commercially available OBG ingredient on postprandial glycemia and appetite sensations immediately after ingestion and following a standardized lunch 3.5 hours later, also exploring whether doses below 4 g of OBGs per 30 g of avCHO could be effective. Nineteen healthy subjects consumed test drinks containing 0 g (Ref), 2 g (BG2), 3 g (BG3), or 4 g (BG4) of OBGs, each providing 30 g of avCHO, in a crossover study. BG2 and BG4 reduced the incremental glucose peak (iPeak) compared to Ref (<i>P</i> &lt; 0.05), with BG3 showing a trend (<i>P</i> = 0.09). BG4 reduced an early glucose incremental area under the curve (iAUC 0-60 min) and improved the post-lunch glycaemic response compared to Ref (<i>P</i> &lt; 0.05). Insulin iPeaks and iAUC (0-120 min) were lower for BG3 and BG4 (<i>P</i> &lt; 0.05). BG4 enhanced satiety and reduced hunger throughout the experimental period (<i>P</i> &lt; 0.05). Doses below 4 g of OBGs per 30 g of avCHO improved postprandial glycemia and appetite, and OBG intake at breakfast enhanced post-lunch glycaemic regulation, suggesting that a lower threshold may be effective in blood glucose management and appetite control.</p>}},
  author       = {{Hossain, Mohammad Mukul and Tovar, Juscelino and Cloetens, Lieselotte and Geraldi, Marina Vilar and Venuti, Chiara and Nilsson, Anne}},
  issn         = {{2042-6496}},
  language     = {{eng}},
  month        = {{05}},
  number       = {{10}},
  pages        = {{4161--4171}},
  publisher    = {{Royal Society of Chemistry}},
  series       = {{Food & Function}},
  title        = {{Oat beta-glucans consumed at breakfast improve glucose tolerance acutely and after a subsequent lunch - a randomized dose-response study in healthy young adults}},
  url          = {{http://dx.doi.org/10.1039/d5fo00353a}},
  doi          = {{10.1039/d5fo00353a}},
  volume       = {{16}},
  year         = {{2025}},
}