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Determinants of maternal and fetal exposure and temporal trends of perfluorinated compounds.

Ode, Amanda LU ; Rylander, Lars LU ; Lindh, Christian LU ; Källén, Karin LU ; Jönsson, Bo A LU ; Gustafsson, Peik LU ; Olofsson, Per LU ; Ivarsson, Sten LU and Rignell-Hydbom, Anna LU (2013) In Environmental Science and Pollution Research 20(11). p.7970-7978
Abstract
In recent years, some perfluorinated compounds (PFCs) have been identified as potentially hazardous substances which are harmful to the environment and human health. According to limited data, PFC levels in humans could be influenced by several determinants. However, the findings are inconsistent. In the present study, perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), and perfluorononanoic acid (PFNA) were measured in paired maternal and cord serum samples (N = 237) collected between 1978 and 2001 in Southern Sweden to study the relationship between these and to investigate several potential determinants of maternal and fetal exposure to PFCs. Time trends of PFCs in Swedish women were also evaluated. The study is a part of... (More)
In recent years, some perfluorinated compounds (PFCs) have been identified as potentially hazardous substances which are harmful to the environment and human health. According to limited data, PFC levels in humans could be influenced by several determinants. However, the findings are inconsistent. In the present study, perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), and perfluorononanoic acid (PFNA) were measured in paired maternal and cord serum samples (N = 237) collected between 1978 and 2001 in Southern Sweden to study the relationship between these and to investigate several potential determinants of maternal and fetal exposure to PFCs. Time trends of PFCs in Swedish women were also evaluated. The study is a part of the Fetal Environment and Neurodevelopment Disorders in Epidemiological Research project. PFOS, PFOA, and PFNA levels (median) were higher in maternal serum (15, 2.1, and 0.24 ng/ml, respectively) than in cord serum (6.5, 1.7, and 0.20 ng/ml, respectively). PFC levels were among the highest in women originating from the Nordic countries and the lowest in women from the Middle East, North Africa, and sub-Saharan Africa. Multiparous women had lower serum PFOA levels (1.7 ng/ml) than primiparous women (2.4 ng/ml). Maternal age, body mass index, cotinine levels, and whether women carried male or female fetuses did not affect serum PFC concentrations. Umbilical cord serum PFC concentrations showed roughly similar patterns as the maternal except for the gestational age where PFC levels increased with advancing gestational age. PFOS levels increased during the study period in native Swedish women. In summary, PFOS levels tend to increase while PFOA and PFNA levels were unchanged between 1978 and 2001 in our study population. Our results demonstrate that maternal country of origin, parity, and gestational age might be associated with PFC exposure. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Environmental Science and Pollution Research
volume
20
issue
11
pages
7970 - 7978
publisher
Springer
external identifiers
  • wos:000325811600042
  • pmid:23436123
  • scopus:84885941221
ISSN
1614-7499
DOI
10.1007/s11356-013-1573-5
language
English
LU publication?
yes
id
b3505324-fee0-4efa-a86f-594f6f231f4d (old id 3559482)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23436123?dopt=Abstract
date added to LUP
2013-03-04 11:05:35
date last changed
2018-10-27 04:59:43
@article{b3505324-fee0-4efa-a86f-594f6f231f4d,
  abstract     = {In recent years, some perfluorinated compounds (PFCs) have been identified as potentially hazardous substances which are harmful to the environment and human health. According to limited data, PFC levels in humans could be influenced by several determinants. However, the findings are inconsistent. In the present study, perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), and perfluorononanoic acid (PFNA) were measured in paired maternal and cord serum samples (N = 237) collected between 1978 and 2001 in Southern Sweden to study the relationship between these and to investigate several potential determinants of maternal and fetal exposure to PFCs. Time trends of PFCs in Swedish women were also evaluated. The study is a part of the Fetal Environment and Neurodevelopment Disorders in Epidemiological Research project. PFOS, PFOA, and PFNA levels (median) were higher in maternal serum (15, 2.1, and 0.24 ng/ml, respectively) than in cord serum (6.5, 1.7, and 0.20 ng/ml, respectively). PFC levels were among the highest in women originating from the Nordic countries and the lowest in women from the Middle East, North Africa, and sub-Saharan Africa. Multiparous women had lower serum PFOA levels (1.7 ng/ml) than primiparous women (2.4 ng/ml). Maternal age, body mass index, cotinine levels, and whether women carried male or female fetuses did not affect serum PFC concentrations. Umbilical cord serum PFC concentrations showed roughly similar patterns as the maternal except for the gestational age where PFC levels increased with advancing gestational age. PFOS levels increased during the study period in native Swedish women. In summary, PFOS levels tend to increase while PFOA and PFNA levels were unchanged between 1978 and 2001 in our study population. Our results demonstrate that maternal country of origin, parity, and gestational age might be associated with PFC exposure.},
  author       = {Ode, Amanda and Rylander, Lars and Lindh, Christian and Källén, Karin and Jönsson, Bo A and Gustafsson, Peik and Olofsson, Per and Ivarsson, Sten and Rignell-Hydbom, Anna},
  issn         = {1614-7499},
  language     = {eng},
  number       = {11},
  pages        = {7970--7978},
  publisher    = {Springer},
  series       = {Environmental Science and Pollution Research},
  title        = {Determinants of maternal and fetal exposure and temporal trends of perfluorinated compounds.},
  url          = {http://dx.doi.org/10.1007/s11356-013-1573-5},
  volume       = {20},
  year         = {2013},
}