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Intake of fruits and vegetables and risk of cancer of the upper aero-digestive tract: the prospective EPIC-study

Boeing, Heiner; Dietrich, Thomas; Hoffmann, Kurt; Pischon, Tobias; Ferrari, Pietro; Lahmann, Petra H.; Boutron-Ruault, Marie Christine; Clavel-Chapelon, Francoise; Allen, Naomi and Key, Tim, et al. (2006) In Cancer Causes and Control 17(7). p.957-969
Abstract
Epidemiologic studies suggest that a high intake of fruits and vegetables is associated with decreased risk of cancers of the upper aero-digestive tract. We studied data from 345,904 subjects of the prospective European Investigation into Cancer and Nutrition (EPIC) recruited in seven European countries, who had completed a dietary questionnaire in 1992-1998. During 2,182,560 person years of observation 352 histologically verified incident squamous cell cancer (SCC) cases (255 males; 97 females) of the oral cavity, pharynx, larynx, and esophagus were identified. Linear and restricted cubic spline Cox regressions were fitted on variables of intake of fruits and vegetables and adjusted for potential confounders. We observed a significant... (More)
Epidemiologic studies suggest that a high intake of fruits and vegetables is associated with decreased risk of cancers of the upper aero-digestive tract. We studied data from 345,904 subjects of the prospective European Investigation into Cancer and Nutrition (EPIC) recruited in seven European countries, who had completed a dietary questionnaire in 1992-1998. During 2,182,560 person years of observation 352 histologically verified incident squamous cell cancer (SCC) cases (255 males; 97 females) of the oral cavity, pharynx, larynx, and esophagus were identified. Linear and restricted cubic spline Cox regressions were fitted on variables of intake of fruits and vegetables and adjusted for potential confounders. We observed a significant inverse association with combined total fruits and vegetables intake (estimated relative risk (RR) = 0.91; 95% confidence interval (95% CI) 0.83-1.00 per 80 g/d of consumption), and nearly significant inverse associations in separate analyses with total fruits and total vegetables intake (RR: 0.97 (95% CI: 0.92-1.02) and RR = 0.89 (95% CI: 0.78-1.02) per 40 g/d of consumption). Overall, vegetable subgroups were not related to risk with the exception of intake of root vegetables in men. Restricted cubic spline regression did not improve the linear model fits except for total fruits and vegetables and total fruits with a significant decrease in risk at low intake levels (< 120 g/d) for fruits. Dietary recommendations should consider the potential benefit of increasing fruits and vegetables consumption for reducing the risk of cancers of the upper aero-digestive tract, particularly at low intake. (Less)
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keywords
prospective study, root vegetables, upper aero-digestive cancer, fruits and vegetables, relative risk, EPIC
in
Cancer Causes and Control
volume
17
issue
7
pages
957 - 969
publisher
Springer
external identifiers
  • wos:000239040100010
  • scopus:33746042158
ISSN
1573-7225
DOI
10.1007/s10552-006-0036-4
language
English
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yes
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c3e166fa-e831-4cf0-b8b5-872689dd4663 (old id 402337)
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2007-09-28 13:38:03
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2019-07-14 03:24:57
@article{c3e166fa-e831-4cf0-b8b5-872689dd4663,
  abstract     = {Epidemiologic studies suggest that a high intake of fruits and vegetables is associated with decreased risk of cancers of the upper aero-digestive tract. We studied data from 345,904 subjects of the prospective European Investigation into Cancer and Nutrition (EPIC) recruited in seven European countries, who had completed a dietary questionnaire in 1992-1998. During 2,182,560 person years of observation 352 histologically verified incident squamous cell cancer (SCC) cases (255 males; 97 females) of the oral cavity, pharynx, larynx, and esophagus were identified. Linear and restricted cubic spline Cox regressions were fitted on variables of intake of fruits and vegetables and adjusted for potential confounders. We observed a significant inverse association with combined total fruits and vegetables intake (estimated relative risk (RR) = 0.91; 95% confidence interval (95% CI) 0.83-1.00 per 80 g/d of consumption), and nearly significant inverse associations in separate analyses with total fruits and total vegetables intake (RR: 0.97 (95% CI: 0.92-1.02) and RR = 0.89 (95% CI: 0.78-1.02) per 40 g/d of consumption). Overall, vegetable subgroups were not related to risk with the exception of intake of root vegetables in men. Restricted cubic spline regression did not improve the linear model fits except for total fruits and vegetables and total fruits with a significant decrease in risk at low intake levels (&lt; 120 g/d) for fruits. Dietary recommendations should consider the potential benefit of increasing fruits and vegetables consumption for reducing the risk of cancers of the upper aero-digestive tract, particularly at low intake.},
  author       = {Boeing, Heiner and Dietrich, Thomas and Hoffmann, Kurt and Pischon, Tobias and Ferrari, Pietro and Lahmann, Petra H. and Boutron-Ruault, Marie Christine and Clavel-Chapelon, Francoise and Allen, Naomi and Key, Tim and Skeie, Guri and Lund, Eiliv and Olsen, Anja and Tjonneland, Anne and Overvad, Kim and Jensen, Majken K. and Rohrmann, Sabine and Linseisen, Jakob and Trichopoulou, Antonia and Bamia, Christina and Psaltopoulou, Theodora and Weinehall, Lars and Johansson, Ingegerd and Sanchez, Maria-Jose and Jakszyn, Paula and Ardanaz, Eva and Amiano, Pilar and Chirlaque, Maria Dolores and Quiros, J. Ramon and Wirfält, Elisabet and Berglund, Göran and Peeters, Petra H. and van Gils, Carla H. and Bueno-de-Mesquita, H. Bas and Buchner, Frederike L. and Berrino, Franco and Palli, Domenico and Sacerdote, Carlotta and Tumino, Rosario and Panico, Salvatore and Bingham, Sheila and Khaw, Kay-Tee and Slimani, Nadia and Norat, Teresa and Jenab, Mazda and Riboli, Elio},
  issn         = {1573-7225},
  keyword      = {prospective study,root vegetables,upper aero-digestive cancer,fruits and vegetables,relative risk,EPIC},
  language     = {eng},
  number       = {7},
  pages        = {957--969},
  publisher    = {Springer},
  series       = {Cancer Causes and Control},
  title        = {Intake of fruits and vegetables and risk of cancer of the upper aero-digestive tract: the prospective EPIC-study},
  url          = {http://dx.doi.org/10.1007/s10552-006-0036-4},
  volume       = {17},
  year         = {2006},
}