Plant foods, dietary fibre and risk of ischaemic heart disease in the European prospective investigation into cancer and nutrition (EPIC) cohort
(2021) In International Journal of Epidemiology 50(1). p.212-222- Abstract
BACKGROUND: Epidemiological evidence indicates that diets rich in plant foods are associated with a lower risk of ischaemic heart disease (IHD), but there is sparse information on fruit and vegetable subtypes and sources of dietary fibre. This study examined the associations of major plant foods, their subtypes and dietary fibre with risk of IHD in the European Prospective Investigation into Cancer and Nutrition (EPIC).
METHODS: We conducted a prospective analysis of 490 311 men and women without a history of myocardial infarction or stroke at recruitment (12.6 years of follow-up, n cases = 8504), in 10 European countries. Dietary intake was assessed using validated questionnaires, calibrated with 24-h recalls. Multivariable Cox... (More)
BACKGROUND: Epidemiological evidence indicates that diets rich in plant foods are associated with a lower risk of ischaemic heart disease (IHD), but there is sparse information on fruit and vegetable subtypes and sources of dietary fibre. This study examined the associations of major plant foods, their subtypes and dietary fibre with risk of IHD in the European Prospective Investigation into Cancer and Nutrition (EPIC).
METHODS: We conducted a prospective analysis of 490 311 men and women without a history of myocardial infarction or stroke at recruitment (12.6 years of follow-up, n cases = 8504), in 10 European countries. Dietary intake was assessed using validated questionnaires, calibrated with 24-h recalls. Multivariable Cox regressions were used to estimate hazard ratios (HR) of IHD.
RESULTS: There was a lower risk of IHD with a higher intake of fruit and vegetables combined [HR per 200 g/day higher intake 0.94, 95% confidence interval (CI): 0.90-0.99, P-trend = 0.009], and with total fruits (per 100 g/day 0.97, 0.95-1.00, P-trend = 0.021). There was no evidence for a reduced risk for fruit subtypes, except for bananas. Risk was lower with higher intakes of nuts and seeds (per 10 g/day 0.90, 0.82-0.98, P-trend = 0.020), total fibre (per 10 g/day 0.91, 0.85-0.98, P-trend = 0.015), fruit and vegetable fibre (per 4 g/day 0.95, 0.91-0.99, P-trend = 0.022) and fruit fibre (per 2 g/day 0.97, 0.95-1.00, P-trend = 0.045). No associations were observed between vegetables, vegetables subtypes, legumes, cereals and IHD risk.
CONCLUSIONS: In this large prospective study, we found some small inverse associations between plant foods and IHD risk, with fruit and vegetables combined being the most strongly inversely associated with risk. Whether these small associations are causal remains unclear.
(Less)
- author
- Perez-Cornago, Aurora
; Crowe, Francesca L
; Appleby, Paul N
; Bradbury, Kathryn E
; Wood, Angela M
; Jakobsen, Marianne Uhre
; Johnson, Laura
; Sacerdote, Carlotta
; Steur, Marinka
; Weiderpass, Elisabete
; Würtz, Anne Mette L
; Kühn, Tilman
; Katzke, Verena
; Trichopoulou, Antonia
; Karakatsani, Anna
; La Vecchia, Carlo
; Masala, Giovanna
; Tumino, Rosario
; Panico, Salvatore
; Sluijs, Ivonne
; Skeie, Guri
; Imaz, Liher
; Petrova, Dafina
; Quirós, J Ramón
; Yohar, Sandra Milena Colorado
; Jakszyn, Paula
; Melander, Olle
LU
; Sonestedt, Emily
LU
; Andersson, Jonas
; Wennberg, Maria
; Aune, Dagfinn
; Riboli, Elio
; Schulze, Matthias B
; di Angelantonio, Emanuele
; Wareham, Nicholas J
; Danesh, John
; Forouhi, Nita G
; Butterworth, Adam S
and Key, Timothy J
(Less) - organization
- publishing date
- 2021
- type
- Contribution to journal
- publication status
- published
- subject
- in
- International Journal of Epidemiology
- volume
- 50
- issue
- 1
- pages
- 212 - 222
- publisher
- Oxford University Press
- external identifiers
-
- scopus:85102658082
- pmid:33245137
- ISSN
- 1464-3685
- DOI
- 10.1093/ije/dyaa155
- language
- English
- LU publication?
- yes
- id
- ca0e1f3f-8341-46de-87c9-fa4758092819
- date added to LUP
- 2021-02-23 14:32:31
- date last changed
- 2025-03-08 14:06:33
@article{ca0e1f3f-8341-46de-87c9-fa4758092819,
abstract = {{<p>BACKGROUND: Epidemiological evidence indicates that diets rich in plant foods are associated with a lower risk of ischaemic heart disease (IHD), but there is sparse information on fruit and vegetable subtypes and sources of dietary fibre. This study examined the associations of major plant foods, their subtypes and dietary fibre with risk of IHD in the European Prospective Investigation into Cancer and Nutrition (EPIC).</p><p>METHODS: We conducted a prospective analysis of 490 311 men and women without a history of myocardial infarction or stroke at recruitment (12.6 years of follow-up, n cases = 8504), in 10 European countries. Dietary intake was assessed using validated questionnaires, calibrated with 24-h recalls. Multivariable Cox regressions were used to estimate hazard ratios (HR) of IHD.</p><p>RESULTS: There was a lower risk of IHD with a higher intake of fruit and vegetables combined [HR per 200 g/day higher intake 0.94, 95% confidence interval (CI): 0.90-0.99, P-trend = 0.009], and with total fruits (per 100 g/day 0.97, 0.95-1.00, P-trend = 0.021). There was no evidence for a reduced risk for fruit subtypes, except for bananas. Risk was lower with higher intakes of nuts and seeds (per 10 g/day 0.90, 0.82-0.98, P-trend = 0.020), total fibre (per 10 g/day 0.91, 0.85-0.98, P-trend = 0.015), fruit and vegetable fibre (per 4 g/day 0.95, 0.91-0.99, P-trend = 0.022) and fruit fibre (per 2 g/day 0.97, 0.95-1.00, P-trend = 0.045). No associations were observed between vegetables, vegetables subtypes, legumes, cereals and IHD risk.</p><p>CONCLUSIONS: In this large prospective study, we found some small inverse associations between plant foods and IHD risk, with fruit and vegetables combined being the most strongly inversely associated with risk. Whether these small associations are causal remains unclear.</p>}},
author = {{Perez-Cornago, Aurora and Crowe, Francesca L and Appleby, Paul N and Bradbury, Kathryn E and Wood, Angela M and Jakobsen, Marianne Uhre and Johnson, Laura and Sacerdote, Carlotta and Steur, Marinka and Weiderpass, Elisabete and Würtz, Anne Mette L and Kühn, Tilman and Katzke, Verena and Trichopoulou, Antonia and Karakatsani, Anna and La Vecchia, Carlo and Masala, Giovanna and Tumino, Rosario and Panico, Salvatore and Sluijs, Ivonne and Skeie, Guri and Imaz, Liher and Petrova, Dafina and Quirós, J Ramón and Yohar, Sandra Milena Colorado and Jakszyn, Paula and Melander, Olle and Sonestedt, Emily and Andersson, Jonas and Wennberg, Maria and Aune, Dagfinn and Riboli, Elio and Schulze, Matthias B and di Angelantonio, Emanuele and Wareham, Nicholas J and Danesh, John and Forouhi, Nita G and Butterworth, Adam S and Key, Timothy J}},
issn = {{1464-3685}},
language = {{eng}},
number = {{1}},
pages = {{212--222}},
publisher = {{Oxford University Press}},
series = {{International Journal of Epidemiology}},
title = {{Plant foods, dietary fibre and risk of ischaemic heart disease in the European prospective investigation into cancer and nutrition (EPIC) cohort}},
url = {{http://dx.doi.org/10.1093/ije/dyaa155}},
doi = {{10.1093/ije/dyaa155}},
volume = {{50}},
year = {{2021}},
}