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The human melanoma proteome atlas-Defining the molecular pathology

Betancourt, Lazaro Hiram LU ; Gil, Jeovanis LU ; Kim, Yonghyo LU ; Doma, Viktória ; Çakır, Uğur ; Sanchez, Aniel LU ; Murillo, Jimmy Rodriguez ; Kuras, Magdalena LU orcid ; Parada, Indira Pla LU orcid and Sugihara, Yutaka LU , et al. (2021) In Clinical and Translational Medicine 11(7). p.1-20
Abstract

The MM500 study is an initiative to map the protein levels in malignant melanoma tumor samples, focused on in-depth histopathology coupled to proteome characterization. The protein levels and localization were determined for a broad spectrum of diverse, surgically isolated melanoma tumors originating from multiple body locations. More than 15,500 proteoforms were identified by mass spectrometry, from which chromosomal and subcellular localization was annotated within both primary and metastatic melanoma. The data generated by global proteomic experiments covered 72% of the proteins identified in the recently reported high stringency blueprint of the human proteome. This study contributes to the NIH Cancer Moonshot initiative combining... (More)

The MM500 study is an initiative to map the protein levels in malignant melanoma tumor samples, focused on in-depth histopathology coupled to proteome characterization. The protein levels and localization were determined for a broad spectrum of diverse, surgically isolated melanoma tumors originating from multiple body locations. More than 15,500 proteoforms were identified by mass spectrometry, from which chromosomal and subcellular localization was annotated within both primary and metastatic melanoma. The data generated by global proteomic experiments covered 72% of the proteins identified in the recently reported high stringency blueprint of the human proteome. This study contributes to the NIH Cancer Moonshot initiative combining detailed histopathological presentation with the molecular characterization for 505 melanoma tumor samples, localized in 26 organs from 232 patients.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Adult, Aged, Aged, 80 and over, Cell Line, Tumor, Chromatography, High Pressure Liquid, Female, Humans, Male, Melanoma/metabolism, Middle Aged, Proteome/analysis, Proteomics/methods, Skin Neoplasms/metabolism, Tandem Mass Spectrometry, Young Adult
in
Clinical and Translational Medicine
volume
11
issue
7
article number
e473
pages
1 - 20
publisher
Wiley
external identifiers
  • pmid:34323403
ISSN
2001-1326
DOI
10.1002/ctm2.473
language
English
LU publication?
yes
additional info
© 2021 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.
id
d060c33f-1ec5-4816-b287-e05bbbb04504
date added to LUP
2022-03-23 09:08:45
date last changed
2023-12-01 02:59:17
@article{d060c33f-1ec5-4816-b287-e05bbbb04504,
  abstract     = {{<p>The MM500 study is an initiative to map the protein levels in malignant melanoma tumor samples, focused on in-depth histopathology coupled to proteome characterization. The protein levels and localization were determined for a broad spectrum of diverse, surgically isolated melanoma tumors originating from multiple body locations. More than 15,500 proteoforms were identified by mass spectrometry, from which chromosomal and subcellular localization was annotated within both primary and metastatic melanoma. The data generated by global proteomic experiments covered 72% of the proteins identified in the recently reported high stringency blueprint of the human proteome. This study contributes to the NIH Cancer Moonshot initiative combining detailed histopathological presentation with the molecular characterization for 505 melanoma tumor samples, localized in 26 organs from 232 patients.</p>}},
  author       = {{Betancourt, Lazaro Hiram and Gil, Jeovanis and Kim, Yonghyo and Doma, Viktória and Çakır, Uğur and Sanchez, Aniel and Murillo, Jimmy Rodriguez and Kuras, Magdalena and Parada, Indira Pla and Sugihara, Yutaka and Appelqvist, Roger and Wieslander, Elisabet and Welinder, Charlotte and Velasquez, Erika and de Almeida, Natália Pinto and Woldmar, Nicole and Marko-Varga, Matilda and Pawłowski, Krzysztof and Eriksson, Jonatan and Szeitz, Beáta and Baldetorp, Bo and Ingvar, Christian and Olsson, Håkan and Lundgren, Lotta and Lindberg, Henrik and Oskolas, Henriett and Lee, Boram and Berge, Ethan and Sjögren, Marie and Eriksson, Carina and Kim, Dasol and Kwon, Ho Jeong and Knudsen, Beatrice and Rezeli, Melinda and Hong, Runyu and Horvatovich, Peter and Miliotis, Tasso and Nishimura, Toshihide and Kato, Harubumi and Steinfelder, Erik and Oppermann, Madalina and Miller, Ken and Florindi, Francesco and Zhou, Qimin and Domont, Gilberto B and Pizzatti, Luciana and Nogueira, Fábio C.S. and Horvath, Peter and Szadai, Leticia and Timar, Jozsef and Karpati, Sarolta and Szasz, A. Marcell and Malm, Johan and Fenyö, David and Ekedahl, Henrik and Németh, István Balázs and Marko-Varga, György}},
  issn         = {{2001-1326}},
  keywords     = {{Adult; Aged; Aged, 80 and over; Cell Line, Tumor; Chromatography, High Pressure Liquid; Female; Humans; Male; Melanoma/metabolism; Middle Aged; Proteome/analysis; Proteomics/methods; Skin Neoplasms/metabolism; Tandem Mass Spectrometry; Young Adult}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{1--20}},
  publisher    = {{Wiley}},
  series       = {{Clinical and Translational Medicine}},
  title        = {{The human melanoma proteome atlas-Defining the molecular pathology}},
  url          = {{http://dx.doi.org/10.1002/ctm2.473}},
  doi          = {{10.1002/ctm2.473}},
  volume       = {{11}},
  year         = {{2021}},
}