Influence of whey supplementation on glycaemic and hormonal excursions at breakfast and lunch in type II diabetic subjects
(2005) In American Journal of Clinical Nutrition 82(1). p.69-75- Abstract
- Background:Whey proteins have insulinotropic effects and reduce the postprandial glycemia in healthy subjects. The mechanism is not known, but insulinogenic amino acids and the incretin hormones seem to be involved.
Objective:The aim was to evaluate whether supplementation of meals with a high glycemic index (GI) with whey proteins may increase insulin secretion and improve blood glucose control in type 2 diabetic subjects.
Design:Fourteen diet-treated subjects with type 2 diabetes were served a high-GI breakfast (white bread) and subsequent high-GI lunch (mashed potatoes with meatballs). The breakfast and lunch meals were supplemented with whey on one day; whey was exchanged for lean ham and lactose... (More) - Background:Whey proteins have insulinotropic effects and reduce the postprandial glycemia in healthy subjects. The mechanism is not known, but insulinogenic amino acids and the incretin hormones seem to be involved.
Objective:The aim was to evaluate whether supplementation of meals with a high glycemic index (GI) with whey proteins may increase insulin secretion and improve blood glucose control in type 2 diabetic subjects.
Design:Fourteen diet-treated subjects with type 2 diabetes were served a high-GI breakfast (white bread) and subsequent high-GI lunch (mashed potatoes with meatballs). The breakfast and lunch meals were supplemented with whey on one day; whey was exchanged for lean ham and lactose on another day. Venous blood samples were drawn before and during 4 h after breakfast and 3 h after lunch for the measurement of blood glucose, serum insulin, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide 1 (GLP-1).
Results:The insulin responses were higher after both breakfast (31%) and lunch (57%) when whey was included in the meal than when whey was not included. After lunch, the blood glucose response was significantly reduced [–21%; 120 min area under the curve (AUC)] after whey ingestion. Postprandial GIP responses were higher after whey ingestion, whereas no differences were found in GLP-1 between the reference and test meals.
Conclusions:It can be concluded that the addition of whey to meals with rapidly digested and absorbed carbohydrates stimulates insulin release and reduces postprandial blood glucose excursion after a lunch meal consisting of mashed potatoes and meatballs in type 2 diabetic subjects. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/757592
- author
- Frid, Anders LU ; Nilsson, Mikael LU ; Holst, Jens Juul and Björck, Inger LU
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Milk • whey • type 2 diabetes • blood glucose • serum insulin • incretin hormones
- in
- American Journal of Clinical Nutrition
- volume
- 82
- issue
- 1
- pages
- 69 - 75
- publisher
- Oxford University Press
- ISSN
- 1938-3207
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Applied Nutrition and Food Chemistry (011001300), Endocrinology (013241500), Pediatrics/Urology/Gynecology/Endocrinology (013240400)
- id
- decfb7d8-e3b9-4ef4-a92a-4c2c7ae2a01a (old id 757592)
- alternative location
- http://www.ajcn.org/cgi/content/full/82/1/69
- date added to LUP
- 2016-04-01 17:07:14
- date last changed
- 2023-04-18 19:17:52
@article{decfb7d8-e3b9-4ef4-a92a-4c2c7ae2a01a,
abstract = {{Background:Whey proteins have insulinotropic effects and reduce the postprandial glycemia in healthy subjects. The mechanism is not known, but insulinogenic amino acids and the incretin hormones seem to be involved. <br/><br>
<br/><br>
Objective:The aim was to evaluate whether supplementation of meals with a high glycemic index (GI) with whey proteins may increase insulin secretion and improve blood glucose control in type 2 diabetic subjects. <br/><br>
<br/><br>
Design:Fourteen diet-treated subjects with type 2 diabetes were served a high-GI breakfast (white bread) and subsequent high-GI lunch (mashed potatoes with meatballs). The breakfast and lunch meals were supplemented with whey on one day; whey was exchanged for lean ham and lactose on another day. Venous blood samples were drawn before and during 4 h after breakfast and 3 h after lunch for the measurement of blood glucose, serum insulin, glucose-dependent insulinotropic polypeptide (GIP), and glucagon-like peptide 1 (GLP-1). <br/><br>
<br/><br>
Results:The insulin responses were higher after both breakfast (31%) and lunch (57%) when whey was included in the meal than when whey was not included. After lunch, the blood glucose response was significantly reduced [–21%; 120 min area under the curve (AUC)] after whey ingestion. Postprandial GIP responses were higher after whey ingestion, whereas no differences were found in GLP-1 between the reference and test meals. <br/><br>
<br/><br>
Conclusions:It can be concluded that the addition of whey to meals with rapidly digested and absorbed carbohydrates stimulates insulin release and reduces postprandial blood glucose excursion after a lunch meal consisting of mashed potatoes and meatballs in type 2 diabetic subjects.}},
author = {{Frid, Anders and Nilsson, Mikael and Holst, Jens Juul and Björck, Inger}},
issn = {{1938-3207}},
keywords = {{Milk • whey • type 2 diabetes • blood glucose • serum insulin • incretin hormones}},
language = {{eng}},
number = {{1}},
pages = {{69--75}},
publisher = {{Oxford University Press}},
series = {{American Journal of Clinical Nutrition}},
title = {{Influence of whey supplementation on glycaemic and hormonal excursions at breakfast and lunch in type II diabetic subjects}},
url = {{http://www.ajcn.org/cgi/content/full/82/1/69}},
volume = {{82}},
year = {{2005}},
}