Neurotrophins and brain insults
Lindvall, Olle LU ; Kokaia, Zaal LU
; Bengzon, Johan
LU
; Elmer, Eskil
LU
and Kokaia, Merab
LU
(1994)
In Trends in Neurosciences
17(11).
p.490-496
- Abstract
- Epileptic, hypoglycaemic, ischaemic and traumatic insults to the brain induce marked changes of gene expression for the neurotrophins, nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3, and their high-affinity receptors, TrkB and TrkC, in cortical and hippocampal neurones. Release of glutamate and influx of Ca2+ are the most important triggering factors. The major hypotheses for the functional effects of the insult-induced neurotrophin changes are protection against neuronal damage and stimulation of sprouting and synaptic reorganization. More insight into the regulation and role of the neurotrophins after brain insults should increase our understanding of pathophysiological mechanisms in, for example,... (More)
- Epileptic, hypoglycaemic, ischaemic and traumatic insults to the brain induce marked changes of gene expression for the neurotrophins, nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3, and their high-affinity receptors, TrkB and TrkC, in cortical and hippocampal neurones. Release of glutamate and influx of Ca2+ are the most important triggering factors. The major hypotheses for the functional effects of the insult-induced neurotrophin changes are protection against neuronal damage and stimulation of sprouting and synaptic reorganization. More insight into the regulation and role of the neurotrophins after brain insults should increase our understanding of pathophysiological mechanisms in, for example, epileptogenesis and cell death, and could lead to new therapeutic strategies. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1108187
- author
- Lindvall, Olle
LU
; Kokaia, Zaal
LU
; Bengzon, Johan
LU
; Elmer, Eskil
LU
and Kokaia, Merab
LU
- organization
- publishing date
- 1994
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Trends in Neurosciences
- volume
- 17
- issue
- 11
- pages
- 490 - 496
- publisher
- Elsevier
- external identifiers
-
- pmid:7531892
- scopus:0028088818
- ISSN
- 1878-108X
- DOI
- 10.1016/0166-2236(94)90139-2
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Neurology, Lund (013027000), Laboratory for Experimental Brain Research (013041000), Neurosurgery (013026000)
- id
- f0780d2c-5f64-4cb2-9e7b-e968d980518b (old id 1108187)
- date added to LUP
- 2016-04-01 16:01:51
- date last changed
- 2021-10-03 04:17:43
@article{f0780d2c-5f64-4cb2-9e7b-e968d980518b,
abstract = {{Epileptic, hypoglycaemic, ischaemic and traumatic insults to the brain induce marked changes of gene expression for the neurotrophins, nerve growth factor, brain-derived neurotrophic factor and neurotrophin-3, and their high-affinity receptors, TrkB and TrkC, in cortical and hippocampal neurones. Release of glutamate and influx of Ca2+ are the most important triggering factors. The major hypotheses for the functional effects of the insult-induced neurotrophin changes are protection against neuronal damage and stimulation of sprouting and synaptic reorganization. More insight into the regulation and role of the neurotrophins after brain insults should increase our understanding of pathophysiological mechanisms in, for example, epileptogenesis and cell death, and could lead to new therapeutic strategies.}},
author = {{Lindvall, Olle and Kokaia, Zaal and Bengzon, Johan and Elmer, Eskil and Kokaia, Merab}},
issn = {{1878-108X}},
language = {{eng}},
number = {{11}},
pages = {{490--496}},
publisher = {{Elsevier}},
series = {{Trends in Neurosciences}},
title = {{Neurotrophins and brain insults}},
url = {{http://dx.doi.org/10.1016/0166-2236(94)90139-2}},
doi = {{10.1016/0166-2236(94)90139-2}},
volume = {{17}},
year = {{1994}},
}