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Structural changes on mri demonstrate specific cerebellar involvement in sle patients—a vbm study

Mårtensson, Johan LU ; Rumetshofer, Theodor LU orcid ; Nystedt, Jessika LU ; Lätt, Jimmy LU ; Nilsson, Petra LU ; Bengtsson, Anders LU ; Jönsen, Andreas LU and Sundgren, Pia C. LU orcid (2021) In Brain Sciences 11(4).
Abstract

The purpose of this study is to investigate possible differences in brain structure, as measured by T1-weighted MRI, between patients with systemic lupus erythematosus (SLE) and healthy controls (HC), and whether any observed differences were in turn more severe in SLE patients with neuropsychiatric manifestations (NPSLE) than those without (non-NPSLE). Structural T1weighted MRI was performed on 69 female SLE patients (mean age = 35.8 years, range = 18–51 years) and 24 age-matched female HC (mean age = 36.8 years, range = 23–52 years) in conjunction with neuropsychological assessment using the CNS Vital Signs test battery. T1-weighted images were preprocessed and analyzed by FSL-VBM. The results show that SLE patients had lower grey... (More)

The purpose of this study is to investigate possible differences in brain structure, as measured by T1-weighted MRI, between patients with systemic lupus erythematosus (SLE) and healthy controls (HC), and whether any observed differences were in turn more severe in SLE patients with neuropsychiatric manifestations (NPSLE) than those without (non-NPSLE). Structural T1weighted MRI was performed on 69 female SLE patients (mean age = 35.8 years, range = 18–51 years) and 24 age-matched female HC (mean age = 36.8 years, range = 23–52 years) in conjunction with neuropsychological assessment using the CNS Vital Signs test battery. T1-weighted images were preprocessed and analyzed by FSL-VBM. The results show that SLE patients had lower grey matter probability values than the control group in the VIIIa of the cerebellum bilaterally, a region that has previously been implied in sensorimotor processing in human and non-human primates. No structural differences for this region were found between NPSLE and non-NPSLE patients. VBM values from the VIIIa region showed a weak positive correlation with the psychomotor speed domain from CNS Vital Signs (p = 0.05, r = 0.21), which is in line with its presumed role as a sensorimotor processing area.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cerebellum, Lupus, Neuroimaging, VBM
in
Brain Sciences
volume
11
issue
4
article number
510
publisher
MDPI AG
external identifiers
  • scopus:85105002641
  • pmid:33923703
ISSN
2076-3425
DOI
10.3390/brainsci11040510
language
English
LU publication?
yes
id
f39185bd-1413-43a1-bed8-9a92c6ced6e8
date added to LUP
2021-05-12 16:52:45
date last changed
2024-06-15 11:10:08
@article{f39185bd-1413-43a1-bed8-9a92c6ced6e8,
  abstract     = {{<p>The purpose of this study is to investigate possible differences in brain structure, as measured by T1-weighted MRI, between patients with systemic lupus erythematosus (SLE) and healthy controls (HC), and whether any observed differences were in turn more severe in SLE patients with neuropsychiatric manifestations (NPSLE) than those without (non-NPSLE). Structural T1weighted MRI was performed on 69 female SLE patients (mean age = 35.8 years, range = 18–51 years) and 24 age-matched female HC (mean age = 36.8 years, range = 23–52 years) in conjunction with neuropsychological assessment using the CNS Vital Signs test battery. T1-weighted images were preprocessed and analyzed by FSL-VBM. The results show that SLE patients had lower grey matter probability values than the control group in the VIIIa of the cerebellum bilaterally, a region that has previously been implied in sensorimotor processing in human and non-human primates. No structural differences for this region were found between NPSLE and non-NPSLE patients. VBM values from the VIIIa region showed a weak positive correlation with the psychomotor speed domain from CNS Vital Signs (p = 0.05, r = 0.21), which is in line with its presumed role as a sensorimotor processing area.</p>}},
  author       = {{Mårtensson, Johan and Rumetshofer, Theodor and Nystedt, Jessika and Lätt, Jimmy and Nilsson, Petra and Bengtsson, Anders and Jönsen, Andreas and Sundgren, Pia C.}},
  issn         = {{2076-3425}},
  keywords     = {{Cerebellum; Lupus; Neuroimaging; VBM}},
  language     = {{eng}},
  number       = {{4}},
  publisher    = {{MDPI AG}},
  series       = {{Brain Sciences}},
  title        = {{Structural changes on mri demonstrate specific cerebellar involvement in sle patients—a vbm study}},
  url          = {{http://dx.doi.org/10.3390/brainsci11040510}},
  doi          = {{10.3390/brainsci11040510}},
  volume       = {{11}},
  year         = {{2021}},
}