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Effects of Whole Brown Bean and Its Isolated Fiber Fraction on Plasma Lipid Profile, Atherosclerosis, Gut Microbiota, and Microbiota-Dependent Metabolites in Apoe-/- Mice

Liu, Jiyun ; Hefni, Mohammed E. ; Witthöft, Cornelia M. ; Bergström, Maria ; Burleigh, Stephen LU ; Nyman, Margareta LU and Hållenius, Frida LU orcid (2022) In Nutrients 14(5).
Abstract
The health benefits of bean consumption are widely recognized and are largely attributed to the dietary fiber content. This study investigated and compared the effects of whole brown beans and an isolated bean dietary fiber fraction on the plasma lipid profile, atherosclerotic plaque amount, gut microbiota, and microbiota-dependent metabolites (cecal short-chain fatty acids (SCFAs) and plasma methylamines) in Apoe−/− mice fed high fat diets for 10.5 weeks. The results showed that both whole bean and the isolated fiber fraction had a tendency to lower atherosclerotic plaque amount, but not plasma lipid concentration. The whole bean diet led to a significantly higher diversity of gut microbiota compared with the high fat... (More)
The health benefits of bean consumption are widely recognized and are largely attributed to the dietary fiber content. This study investigated and compared the effects of whole brown beans and an isolated bean dietary fiber fraction on the plasma lipid profile, atherosclerotic plaque amount, gut microbiota, and microbiota-dependent metabolites (cecal short-chain fatty acids (SCFAs) and plasma methylamines) in Apoe−/− mice fed high fat diets for 10.5 weeks. The results showed that both whole bean and the isolated fiber fraction had a tendency to lower atherosclerotic plaque amount, but not plasma lipid concentration. The whole bean diet led to a significantly higher diversity of gut microbiota compared with the high fat diet. Both bean diets resulted in a lower Firmicutes/Bacteroidetes ratio, higher relative abundance of unclassified S24-7, Prevotella, Bifidobacterium, and unclassified Clostridiales, and lower abundance of Lactobacillus. Both bean diets resulted in higher formation of all cecal SCFAs (higher proportion of propionic acid and lower proportion of acetic acid) and higher plasma trimethylamine N-oxide concentrations compared with the high fat diet. Whole beans and the isolated fiber fraction exerted similar positive effects on atherosclerotic plaque amount, gut microbiota, and cecal SCFAs in Apoe−/− mice compared with the control diets. (Less)
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
brown bean, dietary fiber, atherosclerotic plaques, short-chain fatty acid, trimethylamine N-oxide, gut microbiota, Apoe−/− mice
in
Nutrients
volume
14
issue
5
article number
937
pages
17 pages
publisher
MDPI AG
external identifiers
  • scopus:85125200084
  • pmid:35267913
ISSN
2072-6643
DOI
10.3390/nu14050937
language
English
LU publication?
yes
id
f70e7594-9ff0-4225-9109-2f4aa57105f2
date added to LUP
2022-03-04 11:18:36
date last changed
2025-03-13 07:13:47
@article{f70e7594-9ff0-4225-9109-2f4aa57105f2,
  abstract     = {{The health benefits of bean consumption are widely recognized and are largely attributed to the dietary fiber content. This study investigated and compared the effects of whole brown beans and an isolated bean dietary fiber fraction on the plasma lipid profile, atherosclerotic plaque amount, gut microbiota, and microbiota-dependent metabolites (cecal short-chain fatty acids (SCFAs) and plasma methylamines) in <i>Apoe</i><sup>−/−</sup> mice fed high fat diets for 10.5 weeks. The results showed that both whole bean and the isolated fiber fraction had a tendency to lower atherosclerotic plaque amount, but not plasma lipid concentration. The whole bean diet led to a significantly higher diversity of gut microbiota compared with the high fat diet. Both bean diets resulted in a lower Firmicutes/Bacteroidetes ratio, higher relative abundance of unclassified S24-7, <i>Prevotella</i>, <i>Bifidobacterium</i>, and unclassified <i>Clostridiales</i>, and lower abundance of <i>Lactobacillus</i>. Both bean diets resulted in higher formation of all cecal SCFAs (higher proportion of propionic acid and lower proportion of acetic acid) and higher plasma trimethylamine N-oxide concentrations compared with the high fat diet. Whole beans and the isolated fiber fraction exerted similar positive effects on atherosclerotic plaque amount, gut microbiota, and cecal SCFAs in <i>Apoe</i><sup>−/−</sup> mice compared with the control diets.}},
  author       = {{Liu, Jiyun and Hefni, Mohammed E. and Witthöft, Cornelia M. and Bergström, Maria and Burleigh, Stephen and Nyman, Margareta and Hållenius, Frida}},
  issn         = {{2072-6643}},
  keywords     = {{brown bean; dietary fiber; atherosclerotic plaques; short-chain fatty acid; trimethylamine N-oxide; gut microbiota; Apoe−/− mice}},
  language     = {{eng}},
  month        = {{02}},
  number       = {{5}},
  publisher    = {{MDPI AG}},
  series       = {{Nutrients}},
  title        = {{Effects of Whole Brown Bean and Its Isolated Fiber Fraction on Plasma Lipid Profile, Atherosclerosis, Gut Microbiota, and Microbiota-Dependent Metabolites in Apoe-/- Mice}},
  url          = {{http://dx.doi.org/10.3390/nu14050937}},
  doi          = {{10.3390/nu14050937}},
  volume       = {{14}},
  year         = {{2022}},
}