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Metabolite profiling of obese individuals before and after a one year weight loss program

Geidenstam, N. LU ; Al-Majdoub, M. LU ; Ekman, M. LU ; Spégel, P. LU and Ridderstråle, M. LU (2017) In International Journal of Obesity 41(9). p.1369-1378
Abstract

Objective:We and others have previously characterized changes in circulating metabolite levels following diet-induced weight loss. Our aim was to investigate whether baseline metabolite levels and weight-loss-induced changes in these are predictive of or associated with changes in body mass index (BMI) and metabolic risk traits.Methods:Serum metabolites were analyzed with gas and liquid chromatography/mass spectrometry in 91 obese individuals at baseline and after participating in a 1 year non-surgical weight loss program.ResultsA total of 137 metabolites were identified and semi-quantified at baseline (BMI 42.7±5.8, mean±s.d.) and at follow-up (BMI 36.3±6.6). Weight-loss-induced modification was observed for levels of 57 metabolites in... (More)

Objective:We and others have previously characterized changes in circulating metabolite levels following diet-induced weight loss. Our aim was to investigate whether baseline metabolite levels and weight-loss-induced changes in these are predictive of or associated with changes in body mass index (BMI) and metabolic risk traits.Methods:Serum metabolites were analyzed with gas and liquid chromatography/mass spectrometry in 91 obese individuals at baseline and after participating in a 1 year non-surgical weight loss program.ResultsA total of 137 metabolites were identified and semi-quantified at baseline (BMI 42.7±5.8, mean±s.d.) and at follow-up (BMI 36.3±6.6). Weight-loss-induced modification was observed for levels of 57 metabolites in individuals with â

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Obesity
volume
41
issue
9
pages
10 pages
publisher
Nature Publishing Group
external identifiers
  • scopus:85025076294
  • pmid:28529327
ISSN
0307-0565
DOI
10.1038/ijo.2017.124
language
English
LU publication?
yes
id
fc25a91a-f577-4357-9827-ea0052dd7bcc
date added to LUP
2018-01-25 07:56:05
date last changed
2025-11-12 06:20:14
@article{fc25a91a-f577-4357-9827-ea0052dd7bcc,
  abstract     = {{<p>Objective:We and others have previously characterized changes in circulating metabolite levels following diet-induced weight loss. Our aim was to investigate whether baseline metabolite levels and weight-loss-induced changes in these are predictive of or associated with changes in body mass index (BMI) and metabolic risk traits.Methods:Serum metabolites were analyzed with gas and liquid chromatography/mass spectrometry in 91 obese individuals at baseline and after participating in a 1 year non-surgical weight loss program.ResultsA total of 137 metabolites were identified and semi-quantified at baseline (BMI 42.7±5.8, mean±s.d.) and at follow-up (BMI 36.3±6.6). Weight-loss-induced modification was observed for levels of 57 metabolites in individuals with â</p>}},
  author       = {{Geidenstam, N. and Al-Majdoub, M. and Ekman, M. and Spégel, P. and Ridderstråle, M.}},
  issn         = {{0307-0565}},
  language     = {{eng}},
  month        = {{09}},
  number       = {{9}},
  pages        = {{1369--1378}},
  publisher    = {{Nature Publishing Group}},
  series       = {{International Journal of Obesity}},
  title        = {{Metabolite profiling of obese individuals before and after a one year weight loss program}},
  url          = {{http://dx.doi.org/10.1038/ijo.2017.124}},
  doi          = {{10.1038/ijo.2017.124}},
  volume       = {{41}},
  year         = {{2017}},
}