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- 2011
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Mark
GDNF fails to exert neuroprotection in a rat {alpha}-synuclein model of Parkinson's disease.
(
- Contribution to journal › Article
- 2010
-
Mark
Viral vector-mediated overexpression of α-synuclein as a progressive model of Parkinson's disease
(
- Contribution to journal › Scientific review
-
Mark
Glial Cell Derived Neurotrophic Factor Does not Provide Neuroprotection Against Alpha-Synuclein-Induced Toxicity in a Rat Model of Parkinson's Disease
(
- Contribution to journal › Published meeting abstract
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Mark
The A9 dopamine neuron component in grafts of ventral mesencephalon is an important determinant for recovery of motor function in a rat model of Parkinson's disease
(
- Contribution to journal › Article
-
Mark
Role of serotonin neurons in the induction of levodopa- and graft-induced dyskinesias in Parkinson's disease.
(
- Contribution to journal › Article
- 2009
-
Mark
Differential Infectivity Following Basal Ganglia Administration of Differing AAV Serotypes in Nonhuman Primates
2009) 16th Annual Meeting of the American-Society-for-Neural-Therapy-and-Repair In Cell Transplantation 18(2). p.212-213(
- Contribution to journal › Published meeting abstract
-
Mark
Serotonin neuron-dependent and -independent reduction of dyskinesia by 5-HT(1A) and 5-HT(1B) receptor agonists in the rat Parkinson model.
(
- Contribution to journal › Article
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Mark
Optimization of continuous in vivo DOPA production and studies on ectopic DA synthesis using rAAV5 vectors in Parkinsonian rats
(
- Contribution to journal › Article
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Mark
Reconstruction of the nigrostriatal dopamine pathway in the adult mouse brain.
(
- Contribution to journal › Article
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Mark
Impact of grafted serotonin and dopamine neurons on development of L-DOPA-induced dyskinesias in parkinsonian rats is determined by the extent of dopamine neuron degeneration.
(
- Contribution to journal › Article
-
Mark
Gene therapy for dopamine replacement in Parkinson's disease.
(
- Contribution to journal › Article
- 2008
-
Mark
Combined 5-HT1A and 5-HT1B receptor agonists for the treatment of L-DOPA-induced dyskinesia.
(
- Contribution to journal › Article
-
Mark
In vivo gene delivery to proliferating cells in the striatum generated in response to a 6-hydroxydopamine lesion of the nigro-striatal dopamine pathway
(
- Contribution to journal › Article
-
Mark
Myeloid and lymphoid contribution to non-haematopoietic lineages through irradiation-induced heterotypic cell fusion.
(
- Contribution to journal › Article
-
Mark
Serotonin-dopamine interaction in the induction and maintenance of L-DOPA-induced dyskinesias
(
- Contribution to journal › Article
-
Mark
Involvement of the serotonin system in L-dopa-induced dyskinesias
(
- Contribution to journal › Article
-
Mark
Non-dopaminergic neurons in ventral mesencephalic transplants make widespread axonal connections in the host brain.
(
- Contribution to journal › Article
- 2007
-
Mark
Seizure Suppression by GDNF Gene Therapy in Animal Models of Epilepsy.
(
- Contribution to journal › Article
-
Mark
Brain area, age and viral vector-specific glial cell-line-derived neurotrophic factor expression and transport in rat.
(
- Contribution to journal › Article
-
Mark
The functional impact of the intrastriatal dopamine neuron grafts in parkinsonian rats is reduced with advancing disease
(
- Contribution to journal › Article
-
Mark
Dopamine released from 5-HT terminals is the cause of L-DOPA-induced dyskinesia in parkinsonian rats.
(
- Contribution to journal › Article
-
Mark
Serotonin neuron transplants exacerbate L-DOPA-induced dyskinesias in a rat model of Parkinson's disease
(
- Contribution to journal › Article
- 2006
-
Mark
Graft placement and uneven pattern of reinnervation in the striatum is important for development of graft-induced dyskinesia.
(
- Contribution to journal › Article
-
Mark
Continuous exposure to glial cell line-derived neurotrophic factor to mature dopaminergic transplants impairs the graft's ability to improve spontaneous motor behavior in parkinsonian rats.
(
- Contribution to journal › Article
- 2005
-
Mark
Histological analysis of fetal dopamine cell suspension grafts in two patients with Parkinson's disease gives promising results
(
- Contribution to journal › Debate/Note/Editorial
-
Mark
Reversal of dyskinesias in an animal model of Parkinson's disease by continuous L-DOPA delivery using rAAV vectors.
(
- Contribution to journal › Article
-
Mark
Functional properties and synaptic integration of genetically labelled dopaminergic neurons in intrastriatal grafts.
(
- Contribution to journal › Article
-
Mark
Parkinson's disease: Viral vector delivery of parkin generates model results in rats.
(
- Contribution to journal › Debate/Note/Editorial
-
Mark
Viral Vector Mediated Overexpression of Human alpha-Synuclein in the Nigrostriatal Dopaminergic Neurons: A New Model for Parkinson's Disease.
(
- Contribution to journal › Scientific review
-
Mark
Continuous low-level glial cell line-derived neurotrophic factor delivery using recombinant adeno-associated viral vectors provides neuroprotection and induces behavioral recovery in a primate model of Parkinson's disease
(
- Contribution to journal › Article
-
Mark
Isolation and characterization of neural precursor cells from the Sox1-GFP reporter mouse.
(
- Contribution to journal › Article
-
Mark
Identification of dopaminergic neurons of nigral and ventral tegmental area subtypes in grafts of fetal ventral mesencephalon based on cell morphology, protein expression, and efferent projections.
(
- Contribution to journal › Article
-
Mark
Cell transplantation in Parkinson's disease: how can we make it work?
(
- Contribution to journal › Debate/Note/Editorial
- 2004
-
Mark
Dissociation between short-term increased graft survival and long-term functional improvements in Parkinsonian rats overexpressing glial cell line-derived neurotrophic factor.
(
- Contribution to journal › Article
-
Mark
Regulated delivery of glial cell line-derived neurotrophic factor into rat striatum, using a tetracycline-dependent lentiviral vector.
(
- Contribution to journal › Article
-
Mark
Overexpression of glial cell line-derived neurotrophic factor using a lentiviral vector induces time- and dose-dependent downregulation of tyrosine hydroxylase in the intact nigrostriatal dopamine system.
(
- Contribution to journal › Article
-
Mark
Localized striatal delivery of GDNF as a treatment for Parkinson disease.
(
- Contribution to journal › Article
- 2003
-
Mark
Long-term striatal overexpression of GDNF selectively downregulates tyrosine hydroxylase in the intact nigrostriatal dopamine system.
(
- Contribution to journal › Article
-
Mark
Nigrostriatal {alpha}-synucleinopathy induced by viral vector-mediated overexpression of human {alpha}-synuclein: A new primate model of Parkinson's disease.
(
- Contribution to journal › Article
-
Mark
Anterograde delivery of brain-derived neurotrophic factor to striatum via nigral transduction of recombinant adeno-associated virus increases neuronal death but promotes neurogenic response following stroke.
(
- Contribution to journal › Article
-
Mark
Modeling CNS neurodegeneration by overexpression of disease-causing proteins using viral vectors.
(
- Contribution to journal › Scientific review
- 2002
-
Mark
Neuroprotection in the rat Parkinson model by intrastriatal GDNF gene transfer using a lentiviral vector.
(
- Contribution to journal › Article
-
Mark
Reversal of motor impairments in parkinsonian rats by continuous intrastriatal delivery of L-dopa using rAAV-mediated gene transfer.
(
- Contribution to journal › Article
-
Mark
L-DOPA-Induced Dyskinesia in the Intrastriatal 6-Hydroxydopamine Model of Parkinson's Disease: Relation to Motor and Cellular Parameters of Nigrostriatal Function.
(
- Contribution to journal › Article
-
Mark
Aberrant sprouting and downregulation of tyrosine hydroxylase in lesioned nigrostriatal dopamine neurons induced by long-lasting overexpression of glial cell line derived neurotrophic factor in the striatum by lentiviral gene transfer.
(
- Contribution to journal › Article
-
Mark
Pharmacological validation of behavioural measures of akinesia and dyskinesia in a rat model of Parkinson's disease.
(
- Contribution to journal › Article
-
Mark
Parkinson-like neurodegeneration induced by targeted overexpression of alpha-synuclein in the nigrostriatal system
(
- Contribution to journal › Article
- 2001
-
Mark
Delayed infusion of GDNF promotes recovery of motor function in the partial lesion model of Parkinson's disease
(
- Contribution to journal › Article
-
Mark
Growth and functional efficacy of intrastriatal nigral transplants depend on the extent of nigrostriatal degeneration
2001) In The Journal of Neuroscience : the official journal of the Society for Neuroscience 21(8). p.2889-2896(
- Contribution to journal › Article
-
Mark
Restorative and neuroprotective treatment strategies for Parkinson’s disease: tudies on fetal dopamine cell transplants and GDNF delivery by intracerebral injections and recombinant AAV vectors.
2001)(
- Thesis › Doctoral thesis (compilation)