Carboxylic acids in the hindgut of rats fed higly soluble inulin and Bifidobacterium lactis (Bb-123), Lactobacillus salivarius (UCC 500) or Lactobacillus rhamnous (GG)
(2007) In Scandinavian Journal of Food and Nutrition 51(13-21). p.13-21- Abstract
- Background: Propionic and butyric acids are important nutrients for the mucosal cells and may therefore increase the nutritional status and reduce the permeability of the colonic mucosa. These acids have also been suggested to counteract diseases in the colon, e.g. ulcerative colitis and colon cancer. Different substrates lead to different amounts and patterns of carboxylic acids (CAs).
Objective: To study the effect of probiotics on CA formation in the hindgut of rats given inulin.
Design: The rats were given inulin, marketed as highly soluble by the producer, together with the probiotic bacteria Bifidobacterium lactis (Bb-12), Lactobacillus salivarius (UCC500) or Lactobacillus rhamnosus (GG), or a... (More) - Background: Propionic and butyric acids are important nutrients for the mucosal cells and may therefore increase the nutritional status and reduce the permeability of the colonic mucosa. These acids have also been suggested to counteract diseases in the colon, e.g. ulcerative colitis and colon cancer. Different substrates lead to different amounts and patterns of carboxylic acids (CAs).
Objective: To study the effect of probiotics on CA formation in the hindgut of rats given inulin.
Design: The rats were given inulin, marketed as highly soluble by the producer, together with the probiotic bacteria Bifidobacterium lactis (Bb-12), Lactobacillus salivarius (UCC500) or Lactobacillus rhamnosus (GG), or a mixture of all three.
Results: Rats fed inulin only had comparatively high proportions of propionic and butyric acids throughout the hindgut. When diets were supplemented with Bb-12 and UCC500, the caecal pool of CAs increased compared with inulin only. In the caecum the proportion of butyric acid generally decreased when the rats were fed probiotics. In the distal colon the proportion of propionic and butyric acid was lower, while that of lactic acid was generally higher. The caecal pH in rats fed GG and Bb-12 was lower than expected from the concentration of CAs. Further, rats fed GG had the lowest weight gain and highest caecal tissue weight.
Conclusions: It is possible to modify the formation of CAs by combining inulin with probiotics. Different probiotics had different effects. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/757482
- author
- Nilsson, Ulf LU and Nyman, Margareta LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Bifidobacterium lactis (Bb-12), carboxylic acids, inulin, Lactobacillus rhamnosus (GG), Lactobacillus salivarius (UCC500), prebiotics
- in
- Scandinavian Journal of Food and Nutrition
- volume
- 51
- issue
- 13-21
- pages
- 13 - 21
- publisher
- Taylor & Francis
- external identifiers
-
- scopus:34247275674
- ISSN
- 1748-2976
- DOI
- 10.1080/17482970701266970
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Applied Nutrition and Food Chemistry (011001300)
- id
- 74d902d8-3cdf-48b0-a7f9-13873ce99ef2 (old id 757482)
- date added to LUP
- 2016-04-01 11:52:54
- date last changed
- 2023-09-01 10:53:33
@article{74d902d8-3cdf-48b0-a7f9-13873ce99ef2,
abstract = {{Background: Propionic and butyric acids are important nutrients for the mucosal cells and may therefore increase the nutritional status and reduce the permeability of the colonic mucosa. These acids have also been suggested to counteract diseases in the colon, e.g. ulcerative colitis and colon cancer. Different substrates lead to different amounts and patterns of carboxylic acids (CAs). <br/><br>
<br/><br>
Objective: To study the effect of probiotics on CA formation in the hindgut of rats given inulin. <br/><br>
<br/><br>
Design: The rats were given inulin, marketed as highly soluble by the producer, together with the probiotic bacteria Bifidobacterium lactis (Bb-12), Lactobacillus salivarius (UCC500) or Lactobacillus rhamnosus (GG), or a mixture of all three. <br/><br>
<br/><br>
Results: Rats fed inulin only had comparatively high proportions of propionic and butyric acids throughout the hindgut. When diets were supplemented with Bb-12 and UCC500, the caecal pool of CAs increased compared with inulin only. In the caecum the proportion of butyric acid generally decreased when the rats were fed probiotics. In the distal colon the proportion of propionic and butyric acid was lower, while that of lactic acid was generally higher. The caecal pH in rats fed GG and Bb-12 was lower than expected from the concentration of CAs. Further, rats fed GG had the lowest weight gain and highest caecal tissue weight. <br/><br>
<br/><br>
Conclusions: It is possible to modify the formation of CAs by combining inulin with probiotics. Different probiotics had different effects.}},
author = {{Nilsson, Ulf and Nyman, Margareta}},
issn = {{1748-2976}},
keywords = {{Bifidobacterium lactis (Bb-12); carboxylic acids; inulin; Lactobacillus rhamnosus (GG); Lactobacillus salivarius (UCC500); prebiotics}},
language = {{eng}},
number = {{13-21}},
pages = {{13--21}},
publisher = {{Taylor & Francis}},
series = {{Scandinavian Journal of Food and Nutrition}},
title = {{Carboxylic acids in the hindgut of rats fed higly soluble inulin and Bifidobacterium lactis (Bb-123), Lactobacillus salivarius (UCC 500) or Lactobacillus rhamnous (GG)}},
url = {{http://dx.doi.org/10.1080/17482970701266970}},
doi = {{10.1080/17482970701266970}},
volume = {{51}},
year = {{2007}},
}