A Western dietary pattern is prospectively associated with cardio-metabolic traits and incidence of the metabolic syndrome
Drake, Isabel LU ; Sonestedt, Emily LU
; Ericson, Ulrika
LU
; Wallström, Peter
LU
and Orho-Melander, Marju
LU
(2018)
In British Journal of Nutrition
119(10).
p.1168-1176
- Abstract
The aim of this study was to derive dietary patterns associated with cardio-metabolic traits and to examine whether these predict prospective changes in these traits and incidence of the metabolic syndrome (iMetS). Subjects from the Malmö Diet and Cancer Study cardiovascular cohort without cardio-metabolic disease and related drug treatments at baseline (n 4071; aged 45-67 years, 40 % men) were included. We applied reduced rank regression on thirty-eight foods to derive patterns that explain variation in response variables measured at baseline (waist circumference, TAG, HDL-and LDL-cholesterol, systolic and diastolic blood pressure, fasting glucose and insulin). Patterns were examined in relation to change in cardio-metabolic traits and... (More)
The aim of this study was to derive dietary patterns associated with cardio-metabolic traits and to examine whether these predict prospective changes in these traits and incidence of the metabolic syndrome (iMetS). Subjects from the Malmö Diet and Cancer Study cardiovascular cohort without cardio-metabolic disease and related drug treatments at baseline (n 4071; aged 45-67 years, 40 % men) were included. We applied reduced rank regression on thirty-eight foods to derive patterns that explain variation in response variables measured at baseline (waist circumference, TAG, HDL-and LDL-cholesterol, systolic and diastolic blood pressure, fasting glucose and insulin). Patterns were examined in relation to change in cardio-metabolic traits and iMetS in subjects who were re-examined after 16·7 years (n 2704). Two dietary patterns ('Western' and 'Drinker') were retained and explained 3·2 % of the variation in response variables. The 'Western' dietary pattern was inversely associated with HDL-cholesterol and positively with all other response variables (both at baseline and follow-up), but there was no association with LDL at follow-up. After adjustment for potential confounders, the 'Western' dietary pattern was associated with higher risk of iMetS (hazard ratio Q4 v. Q1: 1·47; 95 % CI 1·23, 1·77; P trend=1·5×10-5). The 'Drinker' dietary pattern primarily explained variation in HDL and was not associated with iMetS. In conclusion, this study supports current food-based dietary guidelines suggesting that a 'Western' dietary pattern with high intakes of sugar-sweetened beverages and red and processed meats and low intakes of wine, cheese, vegetables and high-fibre foods is associated with detrimental effects on cardio-metabolic health.
(Less)
- author
- Drake, Isabel
LU
; Sonestedt, Emily
LU
; Ericson, Ulrika
LU
; Wallström, Peter
LU
and Orho-Melander, Marju
LU
- organization
- publishing date
- 2018-05-28
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Cardio-metabolic traits, Cohorts, Dietary patterns, Metabolic syndrome, Reduced rank regression
- in
- British Journal of Nutrition
- volume
- 119
- issue
- 10
- pages
- 9 pages
- publisher
- Cambridge University Press
- external identifiers
-
- pmid:29759108
- scopus:85047248993
- ISSN
- 0007-1145
- DOI
- 10.1017/S000711451800079X
- language
- English
- LU publication?
- yes
- id
- 810234e3-54e5-42ae-9136-db5f4c8e3543
- date added to LUP
- 2018-05-31 15:20:52
- date last changed
- 2024-04-01 06:32:03
@article{810234e3-54e5-42ae-9136-db5f4c8e3543,
abstract = {{<p>The aim of this study was to derive dietary patterns associated with cardio-metabolic traits and to examine whether these predict prospective changes in these traits and incidence of the metabolic syndrome (iMetS). Subjects from the Malmö Diet and Cancer Study cardiovascular cohort without cardio-metabolic disease and related drug treatments at baseline (n 4071; aged 45-67 years, 40 % men) were included. We applied reduced rank regression on thirty-eight foods to derive patterns that explain variation in response variables measured at baseline (waist circumference, TAG, HDL-and LDL-cholesterol, systolic and diastolic blood pressure, fasting glucose and insulin). Patterns were examined in relation to change in cardio-metabolic traits and iMetS in subjects who were re-examined after 16·7 years (n 2704). Two dietary patterns ('Western' and 'Drinker') were retained and explained 3·2 % of the variation in response variables. The 'Western' dietary pattern was inversely associated with HDL-cholesterol and positively with all other response variables (both at baseline and follow-up), but there was no association with LDL at follow-up. After adjustment for potential confounders, the 'Western' dietary pattern was associated with higher risk of iMetS (hazard ratio Q4 v. Q1: 1·47; 95 % CI 1·23, 1·77; P trend=1·5×10<sup>-5</sup>). The 'Drinker' dietary pattern primarily explained variation in HDL and was not associated with iMetS. In conclusion, this study supports current food-based dietary guidelines suggesting that a 'Western' dietary pattern with high intakes of sugar-sweetened beverages and red and processed meats and low intakes of wine, cheese, vegetables and high-fibre foods is associated with detrimental effects on cardio-metabolic health.</p>}},
author = {{Drake, Isabel and Sonestedt, Emily and Ericson, Ulrika and Wallström, Peter and Orho-Melander, Marju}},
issn = {{0007-1145}},
keywords = {{Cardio-metabolic traits; Cohorts; Dietary patterns; Metabolic syndrome; Reduced rank regression}},
language = {{eng}},
month = {{05}},
number = {{10}},
pages = {{1168--1176}},
publisher = {{Cambridge University Press}},
series = {{British Journal of Nutrition}},
title = {{A Western dietary pattern is prospectively associated with cardio-metabolic traits and incidence of the metabolic syndrome}},
url = {{http://dx.doi.org/10.1017/S000711451800079X}},
doi = {{10.1017/S000711451800079X}},
volume = {{119}},
year = {{2018}},
}