Molecular Neuromodulation

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2016
Mark DREADD Modulation of Transplanted DA Neurons Reveals a Novel Parkinsonian Dyskinesia Mechanism Mediated by the Serotonin 5-HT6 Receptor
Aldrin-Kirk, Patrick ^LU ; Heuer, Andreas ^LU ; Wang, Gang ^LU ; Mattsson, Bengt ^LU ; Lundblad, Martin ^LU ; Parmar, Malin ^LU and Björklund, Tomas ^LU (2016) In Neuron 90(5). p.955-968
- Contribution to journal › Article
2014
Mark Novel AAV-Based Rat Model of Forebrain Synucleinopathy Shows Extensive Pathologies and Progressive Loss of Cholinergic Interneurons.
Aldrin-Kirk, Patrick ^LU ; Davidsson, Marcus ^LU ; Holmqvist, Staffan ^LU ; Li, Jia-Yi ^LU and Björklund, Tomas ^LU (2014) In PLoS ONE 9(7).
- Contribution to journal › Article
Mark Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats.
Holmqvist, Staffan ^LU ; Chutna, Oldriska ^LU ; Bousset, Luc ; Aldrin-Kirk, Patrick ^LU ; Li, Wen ^LU ; Björklund, Tomas ^LU ; Wang, Zhan-You ; Roybon, Laurent ^LU ; Melki, Ronald and Li, Jia-Yi ^LU (2014) In Acta Neuropathologica 128(6). p.805-820
- Contribution to journal › Article
2013
Mark Continuous DOPA synthesis from a single AAV: dosing and efficacy in models of Parkinson's disease.
Cederfjäll, Erik ^LU ; Nilsson, Nathalie ^LU ; Sahin, Gurdal ^LU ; Chu, Yaping ; Nikitidou, Elisabeth ^LU ; Björklund, Tomas ^LU ; Kordower, Jeffrey H and Kirik, Deniz ^LU (2013) In Scientific Reports 3.
- Contribution to journal › Article
Mark A novel α-synuclein-GFP mouse model displays progressive motor impairment, olfactory dysfunction and accumulation of α-synuclein-GFP.
Hansen, Christian ^LU ; Björklund, Tomas ^LU ; Petit, Géraldine ^LU ; Lundblad, Martin ^LU ; Murmu, Reena ^LU ; Brundin, Patrik ^LU and Li, Jia-Yi ^LU (2013) In Neurobiology of Disease 56C(April,30). p.145-155
- Contribution to journal › Article
2012
Mark Design of a Single AAV Vector for Coexpression of TH and GCH1 to Establish Continuous DOPA Synthesis in a Rat Model of Parkinson's Disease.
Cederfjäll, Erik ^LU ; Sahin, Gurdal ^LU ; Kirik, Deniz ^LU and Björklund, Tomas ^LU (2012) In Molecular Therapy 20(7). p.1315-1326
- Contribution to journal › Article
2011
Mark Gene therapy for Parkinson's disease shows promise.
Björklund, Anders ^LU and Björklund, Tomas ^LU (2011) In Science Translational Medicine 3(79). p.1-79
- Contribution to journal › Article
2010
Mark Differential Transduction Following Basal Ganglia Administration of Distinct Pseudotyped AAV Capsid Serotypes in Nonhuman Primates
Dodiya, Hemraj B. ; Björklund, Tomas ^LU ; Stansell, James, III ; Mandel, Ronald J. ; Kirik, Deniz ^LU and Kordower, Jeffrey H. (2010) In Molecular Therapy 18(3). p.579-587
- Contribution to journal › Article
Mark Optimized adeno-associated viral vector-mediated striatal DOPA delivery restores sensorimotor function and prevents dyskinesias in a model of advanced Parkinson's disease.
Björklund, Tomas ^LU ; Carlsson, Thomas ^LU ; Cederfjäll, Erik ^LU ; Carta, Manolo ^LU and Kirik, Deniz ^LU (2010) In Brain 133(Pt 2). p.496-511
- Contribution to journal › Article
Mark Gene therapy for Parkinson's disease.
Björklund, Tomas ^LU and Kordower, Jeffrey H (2010) In Movement Disorders 25 Suppl 1. p.161-173
- Contribution to journal › Article