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Skim milk powder with high content of Maillard reaction products affect weight gain, organ development and intestinal inflammation in early life in rats

Hillman, M. LU ; Weström, B. LU ; Aalaei, K. LU ; Erlanson-Albertsson, C. LU ; Wolinski, J. LU ; Lozinska, L. LU ; Sjöholm, I. LU ; Rayner, M. LU and Landin-Olsson, M. LU (2019) In Food and Chemical Toxicology 125. p.78-84
Abstract

Background: The intestinal tract is important for development of immune tolerance and disturbances are suggested to trigger autoimmune disorders. The aim of this study was to explore the effect of Maillard products in skim milk powder obtained after long storage, compared to fresh skim milk powder. Methods: Young rats were weaned onto a diet based on skim milk powder with high concentration of Maillard products (HM-SM, n = 18) or low (C-SM, n = 18) for one week or four weeks. Weekly body weight and feed consumption were noted. At the end, organ weights, intestinal histology, permeability and inflammatory cytokines were evaluated. Results: Rats fed with HM-SM had after one week, 15% less weight gain than controls, despite equal feed... (More)

Background: The intestinal tract is important for development of immune tolerance and disturbances are suggested to trigger autoimmune disorders. The aim of this study was to explore the effect of Maillard products in skim milk powder obtained after long storage, compared to fresh skim milk powder. Methods: Young rats were weaned onto a diet based on skim milk powder with high concentration of Maillard products (HM-SM, n = 18) or low (C-SM, n = 18) for one week or four weeks. Weekly body weight and feed consumption were noted. At the end, organ weights, intestinal histology, permeability and inflammatory cytokines were evaluated. Results: Rats fed with HM-SM had after one week, 15% less weight gain than controls, despite equal feed intake. After one week thymus and spleen were smaller, intestinal mucosa thickness was increased and acute inflammatory cytokines (IL-17, IL-1β, MCP-1) were elevated. After four weeks, cytokines associated with chronic intestinal inflammation (fractalkine, IP-10, leptin, LIX, MIP-2, RANTES and VEGF) were increased in rats fed with HM-SM compared to C-SM. Conclusion: High content of Maillard products in stored milk powder caused an intestinal inflammation. Whether this is relevant for tolerance development and future autoimmune diseases remains to be explored.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Autoimmune diseases, Immune tolerance, Inflammatory cytokines, Intestinal inflammation, Maillard reactions
in
Food and Chemical Toxicology
volume
125
pages
7 pages
publisher
Elsevier
external identifiers
  • scopus:85059261144
ISSN
0278-6915
DOI
10.1016/j.fct.2018.12.015
language
English
LU publication?
yes
id
0492016c-f9c5-449b-b105-c458b0385274
date added to LUP
2019-01-10 14:33:18
date last changed
2019-03-17 05:11:56
@article{0492016c-f9c5-449b-b105-c458b0385274,
  abstract     = {<p>Background: The intestinal tract is important for development of immune tolerance and disturbances are suggested to trigger autoimmune disorders. The aim of this study was to explore the effect of Maillard products in skim milk powder obtained after long storage, compared to fresh skim milk powder. Methods: Young rats were weaned onto a diet based on skim milk powder with high concentration of Maillard products (HM-SM, n = 18) or low (C-SM, n = 18) for one week or four weeks. Weekly body weight and feed consumption were noted. At the end, organ weights, intestinal histology, permeability and inflammatory cytokines were evaluated. Results: Rats fed with HM-SM had after one week, 15% less weight gain than controls, despite equal feed intake. After one week thymus and spleen were smaller, intestinal mucosa thickness was increased and acute inflammatory cytokines (IL-17, IL-1β, MCP-1) were elevated. After four weeks, cytokines associated with chronic intestinal inflammation (fractalkine, IP-10, leptin, LIX, MIP-2, RANTES and VEGF) were increased in rats fed with HM-SM compared to C-SM. Conclusion: High content of Maillard products in stored milk powder caused an intestinal inflammation. Whether this is relevant for tolerance development and future autoimmune diseases remains to be explored.</p>},
  author       = {Hillman, M. and Weström, B. and Aalaei, K. and Erlanson-Albertsson, C. and Wolinski, J. and Lozinska, L. and Sjöholm, I. and Rayner, M. and Landin-Olsson, M.},
  issn         = {0278-6915},
  keyword      = {Autoimmune diseases,Immune tolerance,Inflammatory cytokines,Intestinal inflammation,Maillard reactions},
  language     = {eng},
  month        = {03},
  pages        = {78--84},
  publisher    = {Elsevier},
  series       = {Food and Chemical Toxicology},
  title        = {Skim milk powder with high content of Maillard reaction products affect weight gain, organ development and intestinal inflammation in early life in rats},
  url          = {http://dx.doi.org/10.1016/j.fct.2018.12.015},
  volume       = {125},
  year         = {2019},
}