Advanced

Lingonberries and their two separated fractions differently alter the gut microbiota, improve metabolic functions, reduce gut inflammatory properties, and improve brain function in ApoE−/− mice fed high-fat diet

Marungruang, Nittaya LU ; Kovalenko, Tatiana; Osadchenko, Iryna LU ; Voss, Ulrikke LU ; Huang, Fang; Burleigh, Stephen LU ; Ushakova, Galyna; Skibo, Galyna; Nyman, Margareta LU and Prykhodko, Olena LU , et al. (2018) In Nutritional Neuroscience
Abstract

Lingonberries (LB) have been shown to have beneficial metabolic effects, which is associated with an altered gut microbiota. This study investigated whether the LB-induced improvements were associated with altered gut- and neuroinflammatory markers, as well as cognitive performance in ApoE−/− mice fed high-fat (HF) diets. Whole LB, as well as two separated fractions of LB were investigated. Eight-week-old male ApoE−/− mice were fed HF diets (38% kcal) containing whole LB (wLB), or the insoluble (insLB) and soluble fractions (solLB) of LB for 8 weeks. Inclusion of wLB and insLB fraction reduced weight gain, reduced fat deposition and improved glucose response. Both wLB and insLB fraction also changed the caecal microbiota composition and... (More)

Lingonberries (LB) have been shown to have beneficial metabolic effects, which is associated with an altered gut microbiota. This study investigated whether the LB-induced improvements were associated with altered gut- and neuroinflammatory markers, as well as cognitive performance in ApoE−/− mice fed high-fat (HF) diets. Whole LB, as well as two separated fractions of LB were investigated. Eight-week-old male ApoE−/− mice were fed HF diets (38% kcal) containing whole LB (wLB), or the insoluble (insLB) and soluble fractions (solLB) of LB for 8 weeks. Inclusion of wLB and insLB fraction reduced weight gain, reduced fat deposition and improved glucose response. Both wLB and insLB fraction also changed the caecal microbiota composition and reduced intestinal S100B protein levels. The solLB fraction mainly induced weight loss in the mice. There were no significant changes in spatial memory, but significant increases in synaptic density in the hippocampus were observed in the brain of mice-fed wLB and insLB. Thus, this study shows that all lingonberry fractions counteracted negative effects of HF feedings on metabolic parameters. Also, wLB and insLB fraction showed to potentially improve brain function in the mice.

(Less)
Please use this url to cite or link to this publication:
author
, et al. (More)
(Less)
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
Brain and cognition, Dietary fibre, Gut microbiota, Hippocampus, Inflammation, Lingonberries, Metabolic function, Neuroinflammation
in
Nutritional Neuroscience
publisher
Taylor & Francis
external identifiers
  • scopus:85055420394
ISSN
1028-415X
DOI
10.1080/1028415X.2018.1536423
language
English
LU publication?
yes
id
07aa5b4d-c0a6-45c6-bf55-917095d6ed20
date added to LUP
2018-11-20 12:17:57
date last changed
2019-02-20 11:36:50
@article{07aa5b4d-c0a6-45c6-bf55-917095d6ed20,
  abstract     = {<p>Lingonberries (LB) have been shown to have beneficial metabolic effects, which is associated with an altered gut microbiota. This study investigated whether the LB-induced improvements were associated with altered gut- and neuroinflammatory markers, as well as cognitive performance in ApoE−/− mice fed high-fat (HF) diets. Whole LB, as well as two separated fractions of LB were investigated. Eight-week-old male ApoE−/− mice were fed HF diets (38% kcal) containing whole LB (wLB), or the insoluble (insLB) and soluble fractions (solLB) of LB for 8 weeks. Inclusion of wLB and insLB fraction reduced weight gain, reduced fat deposition and improved glucose response. Both wLB and insLB fraction also changed the caecal microbiota composition and reduced intestinal S100B protein levels. The solLB fraction mainly induced weight loss in the mice. There were no significant changes in spatial memory, but significant increases in synaptic density in the hippocampus were observed in the brain of mice-fed wLB and insLB. Thus, this study shows that all lingonberry fractions counteracted negative effects of HF feedings on metabolic parameters. Also, wLB and insLB fraction showed to potentially improve brain function in the mice.</p>},
  author       = {Marungruang, Nittaya and Kovalenko, Tatiana and Osadchenko, Iryna and Voss, Ulrikke and Huang, Fang and Burleigh, Stephen and Ushakova, Galyna and Skibo, Galyna and Nyman, Margareta and Prykhodko, Olena and Hållenius, Frida Fåk},
  issn         = {1028-415X},
  keyword      = {Brain and cognition,Dietary fibre,Gut microbiota,Hippocampus,Inflammation,Lingonberries,Metabolic function,Neuroinflammation},
  language     = {eng},
  month        = {10},
  publisher    = {Taylor & Francis},
  series       = {Nutritional Neuroscience},
  title        = {Lingonberries and their two separated fractions differently alter the gut microbiota, improve metabolic functions, reduce gut inflammatory properties, and improve brain function in ApoE−/− mice fed high-fat diet},
  url          = {http://dx.doi.org/10.1080/1028415X.2018.1536423},
  year         = {2018},
}