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Mediterranean diet and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition cohort

Molina-Montes, Esther ; Sánchez, María José ; Buckland, Genevieve ; Bueno-De-Mesquita, H. B. ; Weiderpass, Elisabete ; Amiano, Pilar ; Wark, Petra A. ; Kühn, Tilman ; Katzke, Verena and Huerta, José María , et al. (2017) In British Journal of Cancer 116(6). p.811-820
Abstract

Background:The Mediterranean diet (MD) has been proposed as a means for cancer prevention, but little evidence has been accrued regarding its potential to prevent pancreatic cancer. We investigated the association between the adherence to the MD and pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.Methods:Over half a million participants from 10 European countries were followed up for over 11 years, after which 865 newly diagnosed exocrine pancreatic cancer cases were identified. Adherence to the MD was estimated through an adapted score without the alcohol component (arMED) to discount alcohol-related harmful effects. Cox proportional hazards regression models, stratified by... (More)

Background:The Mediterranean diet (MD) has been proposed as a means for cancer prevention, but little evidence has been accrued regarding its potential to prevent pancreatic cancer. We investigated the association between the adherence to the MD and pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.Methods:Over half a million participants from 10 European countries were followed up for over 11 years, after which 865 newly diagnosed exocrine pancreatic cancer cases were identified. Adherence to the MD was estimated through an adapted score without the alcohol component (arMED) to discount alcohol-related harmful effects. Cox proportional hazards regression models, stratified by age, sex and centre, and adjusted for energy intake, body mass index, smoking status, alcohol intake and diabetes status at recruitment, were used to estimate hazard ratios (HRs) associated with pancreatic cancer and their corresponding 95% confidence intervals (CIs).Results:Adherence to the arMED score was not associated with risk of pancreatic cancer (HR high vs low adherence=0.99; 95% CI: 0.77-1.26, and HR per increments of two units in adherence to arMED=1.00; 95% CI: 0.94-1.06). There was no convincing evidence for heterogeneity by smoking status, body mass index, diabetes or European region. There was also no evidence of significant associations in analyses involving microscopically confirmed cases, plausible reporters of energy intake or other definitions of the MD pattern.Conclusions:A high adherence to the MD is not associated with pancreatic cancer risk in the EPIC study.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cohort study, Mediterranean diet, pancreatic cancer
in
British Journal of Cancer
volume
116
issue
6
pages
10 pages
publisher
Nature Publishing Group
external identifiers
  • pmid:28170373
  • scopus:85011915417
ISSN
0007-0920
DOI
10.1038/bjc.2017.14
language
English
LU publication?
yes
id
0a5c1af0-3c13-4a85-be94-097bd0d7c26a
date added to LUP
2020-09-14 15:45:58
date last changed
2020-10-20 03:42:37
@article{0a5c1af0-3c13-4a85-be94-097bd0d7c26a,
  abstract     = {<p>Background:The Mediterranean diet (MD) has been proposed as a means for cancer prevention, but little evidence has been accrued regarding its potential to prevent pancreatic cancer. We investigated the association between the adherence to the MD and pancreatic cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.Methods:Over half a million participants from 10 European countries were followed up for over 11 years, after which 865 newly diagnosed exocrine pancreatic cancer cases were identified. Adherence to the MD was estimated through an adapted score without the alcohol component (arMED) to discount alcohol-related harmful effects. Cox proportional hazards regression models, stratified by age, sex and centre, and adjusted for energy intake, body mass index, smoking status, alcohol intake and diabetes status at recruitment, were used to estimate hazard ratios (HRs) associated with pancreatic cancer and their corresponding 95% confidence intervals (CIs).Results:Adherence to the arMED score was not associated with risk of pancreatic cancer (HR high vs low adherence=0.99; 95% CI: 0.77-1.26, and HR per increments of two units in adherence to arMED=1.00; 95% CI: 0.94-1.06). There was no convincing evidence for heterogeneity by smoking status, body mass index, diabetes or European region. There was also no evidence of significant associations in analyses involving microscopically confirmed cases, plausible reporters of energy intake or other definitions of the MD pattern.Conclusions:A high adherence to the MD is not associated with pancreatic cancer risk in the EPIC study.</p>},
  author       = {Molina-Montes, Esther and Sánchez, María José and Buckland, Genevieve and Bueno-De-Mesquita, H. B. and Weiderpass, Elisabete and Amiano, Pilar and Wark, Petra A. and Kühn, Tilman and Katzke, Verena and Huerta, José María and Ardanaz, Eva and Quirós, José Ramón and Affret, Aurélie and His, Mathilde and Boutron-Ruault, Marie Christine and Peeters, Petra H. and Ye, Weimin and Sund, Malin and Boeing, Heiner and Iqbal, Khalid and Ohlsson, Bodil and Sonestedt, Emily and Tjønneland, Anne and Petersen, Kristina E.N. and Travis, Ruth C. and Skeie, Guri and Agnoli, Claudia and Panico, Salvatore and Palli, Domenico and Tumino, Rosario and Sacerdote, Carlotta and Freisling, Heinz and Huybrechts, Inge and Overvad, Kim and Trichopoulou, Antonia and Bamia, Christina and Vasilopoulou, Effie and Wareham, Nick and Khaw, Kay Tee and Cross, Amanda J. and Ward, Heather A. and Riboli, Elio and Duell, Eric J.},
  issn         = {0007-0920},
  language     = {eng},
  month        = {03},
  number       = {6},
  pages        = {811--820},
  publisher    = {Nature Publishing Group},
  series       = {British Journal of Cancer},
  title        = {Mediterranean diet and risk of pancreatic cancer in the European Prospective Investigation into Cancer and Nutrition cohort},
  url          = {http://dx.doi.org/10.1038/bjc.2017.14},
  doi          = {10.1038/bjc.2017.14},
  volume       = {116},
  year         = {2017},
}