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Metabolic effects of whole grain wheat and whole grain rye in the C57BL/6J mouse.

Axling, Ulrika LU ; Rosén, Liza LU ; Östman, Elin LU ; Ström, Kristoffer LU ; Wierup, Nils LU ; Björck, Inger LU and Holm, Cecilia LU (2010) In Nutrition 26. p.230-239
Abstract
OBJECTIVE: A diet rich in whole grain cereals is suggested to protect against type 2 diabetes and facilitate body weight regulation. However, little is known about the impact of different cereals and the underlying mechanisms. The objective of this study was to compare the long-term metabolic effects of diets supplemented with whole grain wheat or whole grain rye in the C57BL/6J mouse. METHODS: Mice were fed the whole grain supplements in a low-fat background diet for 22 wk. Oral and intravenous glucose tolerance tests were performed during the study and in vitro insulin secretion assays were performed at the end of the study. Body weight, energy intake, body fat content, and plasma parameters were measured during the study. RESULTS: A... (More)
OBJECTIVE: A diet rich in whole grain cereals is suggested to protect against type 2 diabetes and facilitate body weight regulation. However, little is known about the impact of different cereals and the underlying mechanisms. The objective of this study was to compare the long-term metabolic effects of diets supplemented with whole grain wheat or whole grain rye in the C57BL/6J mouse. METHODS: Mice were fed the whole grain supplements in a low-fat background diet for 22 wk. Oral and intravenous glucose tolerance tests were performed during the study and in vitro insulin secretion assays were performed at the end of the study. Body weight, energy intake, body fat content, and plasma parameters were measured during the study. RESULTS: A dietary supplement of whole grain rye suppressed body weight gain and resulted in significantly decreased adiposity, plasma leptin, total plasma cholesterol, and triacylglycerols compared with a supplement of whole grain wheat. Also, a slight improvement in insulin sensitivity was observed in the rye group compared with the wheat group. The decreases in body weight and adiposity were observed in the absence of differences in energy intake. CONCLUSION: Long-term administration of whole grain rye evokes a different metabolic profile compared with whole grain wheat in the C57BL/6J mouse, the primary difference being that whole grain rye reduces body weight and adiposity compared with whole grain wheat. In addition, whole grain rye slightly improves insulin sensitivity and lowers total plasma cholesterol. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nutrition
volume
26
pages
230 - 239
publisher
Elsevier
external identifiers
  • wos:000276331900013
  • pmid:19647415
  • scopus:73449089395
ISSN
1873-1244
DOI
10.1016/j.nut.2009.06.007
language
English
LU publication?
yes
id
6bd0dfad-1945-475e-a079-702f1904dcfb (old id 1470192)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19647415?dopt=Abstract
date added to LUP
2009-09-04 10:49:47
date last changed
2018-05-29 11:40:54
@article{6bd0dfad-1945-475e-a079-702f1904dcfb,
  abstract     = {OBJECTIVE: A diet rich in whole grain cereals is suggested to protect against type 2 diabetes and facilitate body weight regulation. However, little is known about the impact of different cereals and the underlying mechanisms. The objective of this study was to compare the long-term metabolic effects of diets supplemented with whole grain wheat or whole grain rye in the C57BL/6J mouse. METHODS: Mice were fed the whole grain supplements in a low-fat background diet for 22 wk. Oral and intravenous glucose tolerance tests were performed during the study and in vitro insulin secretion assays were performed at the end of the study. Body weight, energy intake, body fat content, and plasma parameters were measured during the study. RESULTS: A dietary supplement of whole grain rye suppressed body weight gain and resulted in significantly decreased adiposity, plasma leptin, total plasma cholesterol, and triacylglycerols compared with a supplement of whole grain wheat. Also, a slight improvement in insulin sensitivity was observed in the rye group compared with the wheat group. The decreases in body weight and adiposity were observed in the absence of differences in energy intake. CONCLUSION: Long-term administration of whole grain rye evokes a different metabolic profile compared with whole grain wheat in the C57BL/6J mouse, the primary difference being that whole grain rye reduces body weight and adiposity compared with whole grain wheat. In addition, whole grain rye slightly improves insulin sensitivity and lowers total plasma cholesterol.},
  author       = {Axling, Ulrika and Rosén, Liza and Östman, Elin and Ström, Kristoffer and Wierup, Nils and Björck, Inger and Holm, Cecilia},
  issn         = {1873-1244},
  language     = {eng},
  pages        = {230--239},
  publisher    = {Elsevier},
  series       = {Nutrition},
  title        = {Metabolic effects of whole grain wheat and whole grain rye in the C57BL/6J mouse.},
  url          = {http://dx.doi.org/10.1016/j.nut.2009.06.007},
  volume       = {26},
  year         = {2010},
}