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Coffee and tea drinking in relation to the risk of differentiated thyroid carcinoma : results from the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Zamora-Ros, Raul; Alghamdi, Muath A.; Cayssials, Valerie; Franceschi, Silvia; Almquist, Martin LU ; Hennings, Joakim; Sandström, Maria; Tsilidis, Konstantinos K.; Weiderpass, Elisabete and Boutron-Ruault, Marie Christine, et al. (2018) In European Journal of Nutrition
Abstract

Purpose: Coffee and tea constituents have shown several anti-carcinogenic activities in cellular and animal studies, including against thyroid cancer (TC). However, epidemiological evidence is still limited and inconsistent. Therefore, we aimed to investigate this association in a large prospective study. Methods: The study was conducted in the EPIC (European Prospective Investigation into Cancer and Nutrition) cohort, which included 476,108 adult men and women. Coffee and tea intakes were assessed through validated country-specific dietary questionnaires. Results: During a mean follow-up of 14 years, 748 first incident differentiated TC cases (including 601 papillary and 109 follicular TC) were identified. Coffee consumption (per 100... (More)

Purpose: Coffee and tea constituents have shown several anti-carcinogenic activities in cellular and animal studies, including against thyroid cancer (TC). However, epidemiological evidence is still limited and inconsistent. Therefore, we aimed to investigate this association in a large prospective study. Methods: The study was conducted in the EPIC (European Prospective Investigation into Cancer and Nutrition) cohort, which included 476,108 adult men and women. Coffee and tea intakes were assessed through validated country-specific dietary questionnaires. Results: During a mean follow-up of 14 years, 748 first incident differentiated TC cases (including 601 papillary and 109 follicular TC) were identified. Coffee consumption (per 100 mL/day) was not associated either with total differentiated TC risk (HRcalibrated 1.00, 95% CI 0.97–1.04) or with the risk of TC subtypes. Tea consumption (per 100 mL/day) was not associated with the risk of total differentiated TC (HRcalibrated 0.98, 95% CI 0.95–1.02) and papillary tumor (HRcalibrated 0.99, 95% CI 0.95–1.03), whereas an inverse association was found with follicular tumor risk (HRcalibrated 0.90, 95% CI 0.81–0.99), but this association was based on a sub-analysis with a small number of cancer cases. Conclusions: In this large prospective study, coffee and tea consumptions were not associated with TC risk.

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epub
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keywords
Coffee, Cohort, EPIC, Intake, Tea, Thyroid cancer
in
European Journal of Nutrition
publisher
Springer
external identifiers
  • scopus:85058140798
ISSN
1436-6207
DOI
10.1007/s00394-018-1874-z
language
English
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yes
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2014b349-0cef-4d57-8f48-ea7d3f9776ab
date added to LUP
2019-01-07 16:09:29
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2019-02-26 11:21:46
@article{2014b349-0cef-4d57-8f48-ea7d3f9776ab,
  abstract     = {<p>Purpose: Coffee and tea constituents have shown several anti-carcinogenic activities in cellular and animal studies, including against thyroid cancer (TC). However, epidemiological evidence is still limited and inconsistent. Therefore, we aimed to investigate this association in a large prospective study. Methods: The study was conducted in the EPIC (European Prospective Investigation into Cancer and Nutrition) cohort, which included 476,108 adult men and women. Coffee and tea intakes were assessed through validated country-specific dietary questionnaires. Results: During a mean follow-up of 14 years, 748 first incident differentiated TC cases (including 601 papillary and 109 follicular TC) were identified. Coffee consumption (per 100 mL/day) was not associated either with total differentiated TC risk (HR<sub>calibrated</sub> 1.00, 95% CI 0.97–1.04) or with the risk of TC subtypes. Tea consumption (per 100 mL/day) was not associated with the risk of total differentiated TC (HR<sub>calibrated</sub> 0.98, 95% CI 0.95–1.02) and papillary tumor (HR<sub>calibrated</sub> 0.99, 95% CI 0.95–1.03), whereas an inverse association was found with follicular tumor risk (HR<sub>calibrated</sub> 0.90, 95% CI 0.81–0.99), but this association was based on a sub-analysis with a small number of cancer cases. Conclusions: In this large prospective study, coffee and tea consumptions were not associated with TC risk.</p>},
  author       = {Zamora-Ros, Raul and Alghamdi, Muath A. and Cayssials, Valerie and Franceschi, Silvia and Almquist, Martin and Hennings, Joakim and Sandström, Maria and Tsilidis, Konstantinos K. and Weiderpass, Elisabete and Boutron-Ruault, Marie Christine and Hammer Bech, Bodil and Overvad, Kim and Tjønneland, Anne and Petersen, Kristina E.N. and Mancini, Francesca Romana and Mahamat-Saleh, Yahya and Bonnet, Fabrice and Kühn, Tilman and Fortner, Renée T. and Boeing, Heiner and Trichopoulou, Antonia and Bamia, Christina and Martimianaki, Georgia and Masala, Giovanna and Grioni, Sara and Panico, Salvatore and Tumino, Rosario and Fasanelli, Francesca and Skeie, Guri and Braaten, Tonje and Lasheras, Cristina and Salamanca-Fernández, Elena and Amiano, Pilar and Chirlaque, Maria Dolores and Barricarte, Aurelio and Manjer, Jonas and Wallström, Peter and Bueno-de-Mesquita, H. Bas and Peeters, Petra H. and Khaw, Kay Thee and Wareham, Nicholas J. and Schmidt, Julie A. and Aune, Dagfinn and Byrnes, Graham and Scalbert, Augustin and Agudo, Antonio and Rinaldi, Sabina},
  issn         = {1436-6207},
  keyword      = {Coffee,Cohort,EPIC,Intake,Tea,Thyroid cancer},
  language     = {eng},
  month        = {12},
  publisher    = {Springer},
  series       = {European Journal of Nutrition},
  title        = {Coffee and tea drinking in relation to the risk of differentiated thyroid carcinoma : results from the European Prospective Investigation into Cancer and Nutrition (EPIC) study},
  url          = {http://dx.doi.org/10.1007/s00394-018-1874-z},
  year         = {2018},
}