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Per-and polyfluoroalkyl substances in early pregnancy and risk for preeclampsia : A case-control study in southern Sweden

Rylander, Lars LU orcid ; Lindh, Christian H. LU orcid ; Hansson, Stefan R. LU orcid ; Broberg, Karin LU orcid and Källén, Karin LU (2020) In Toxics 8(2).
Abstract

Preeclampsia is one of the most common causes of perinatal and maternal morbidity/ mortality. One suggested environmental risk factor is exposure to endocrine-disrupting pollutants such as per-and polyfluoroalkyl substances (PFAS). The present case-control study in southern Sweden aims to investigate the hypothesized association between serum concentrations of PFAS in early pregnancy and the risk of developing preeclampsia. The study included 296 women diagnosed with preeclampsia (cases) and 580 healthy pregnant women (controls). Maternal serum samples were obtained from a biobank of samples collected in early pregnancy in connection with screening for infections. Serum concentrations of perfluorooctanoic acid (PFOA), perfluorooctane... (More)

Preeclampsia is one of the most common causes of perinatal and maternal morbidity/ mortality. One suggested environmental risk factor is exposure to endocrine-disrupting pollutants such as per-and polyfluoroalkyl substances (PFAS). The present case-control study in southern Sweden aims to investigate the hypothesized association between serum concentrations of PFAS in early pregnancy and the risk of developing preeclampsia. The study included 296 women diagnosed with preeclampsia (cases) and 580 healthy pregnant women (controls). Maternal serum samples were obtained from a biobank of samples collected in early pregnancy in connection with screening for infections. Serum concentrations of perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorononanoic acid (PFNA), and perfluorohexane sulfonate (PFHxS) were analyzed using liquid chromatography-tandem-mass-spectrometry (LC/MS/MS). Among primiparous women, there were no differences in PFAS concentrations in early pregnancy between the cases and the controls whereas among multipara women, the cases had significantly higher concentrations of PFNA (median concentrations were 0.44 and 0.38 ng/mL, p = 0.04). When individual PFAS were categorized into quartiles and adjustment for potential confounders was performed, the women in the highest quartiles had no significant increased risks of developing preeclampsia as compared with women in the lowest category. In conclusion, the present study provides limited support for the hypothesized association between PFAS and preeclampsia in a population with relatively low exposure levels.

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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Biobank, PFAS, PFHxS, PFNA, PFOA, PFOS, Preeclampsia, Register, Sweden
in
Toxics
volume
8
issue
2
article number
43
publisher
MDPI AG
external identifiers
  • scopus:85087556725
ISSN
2305-6304
DOI
10.3390/TOXICS8020043
language
English
LU publication?
yes
id
3c3f864b-c835-4851-a18e-6e97baa74720
date added to LUP
2020-07-16 12:50:54
date last changed
2024-02-16 19:23:08
@article{3c3f864b-c835-4851-a18e-6e97baa74720,
  abstract     = {{<p>Preeclampsia is one of the most common causes of perinatal and maternal morbidity/ mortality. One suggested environmental risk factor is exposure to endocrine-disrupting pollutants such as per-and polyfluoroalkyl substances (PFAS). The present case-control study in southern Sweden aims to investigate the hypothesized association between serum concentrations of PFAS in early pregnancy and the risk of developing preeclampsia. The study included 296 women diagnosed with preeclampsia (cases) and 580 healthy pregnant women (controls). Maternal serum samples were obtained from a biobank of samples collected in early pregnancy in connection with screening for infections. Serum concentrations of perfluorooctanoic acid (PFOA), perfluorooctane sulfonate (PFOS), perfluorononanoic acid (PFNA), and perfluorohexane sulfonate (PFHxS) were analyzed using liquid chromatography-tandem-mass-spectrometry (LC/MS/MS). Among primiparous women, there were no differences in PFAS concentrations in early pregnancy between the cases and the controls whereas among multipara women, the cases had significantly higher concentrations of PFNA (median concentrations were 0.44 and 0.38 ng/mL, p = 0.04). When individual PFAS were categorized into quartiles and adjustment for potential confounders was performed, the women in the highest quartiles had no significant increased risks of developing preeclampsia as compared with women in the lowest category. In conclusion, the present study provides limited support for the hypothesized association between PFAS and preeclampsia in a population with relatively low exposure levels.</p>}},
  author       = {{Rylander, Lars and Lindh, Christian H. and Hansson, Stefan R. and Broberg, Karin and Källén, Karin}},
  issn         = {{2305-6304}},
  keywords     = {{Biobank; PFAS; PFHxS; PFNA; PFOA; PFOS; Preeclampsia; Register; Sweden}},
  language     = {{eng}},
  number       = {{2}},
  publisher    = {{MDPI AG}},
  series       = {{Toxics}},
  title        = {{Per-and polyfluoroalkyl substances in early pregnancy and risk for preeclampsia : A case-control study in southern Sweden}},
  url          = {{http://dx.doi.org/10.3390/TOXICS8020043}},
  doi          = {{10.3390/TOXICS8020043}},
  volume       = {{8}},
  year         = {{2020}},
}