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Metabolite-related dietary patterns and the development of islet autoimmunity

Johnson, Randi K. ; Lernmark, Åke LU ; Andrén Aronsson, Carin LU ; Ask, Maria LU ; Bremer, Jenny LU ; Cilio, Corrado LU ; Ericson-Hallström, Emelie LU ; Björne Fors, Annika LU ; Fransson, Lina LU and Gard, Thomas LU , et al. (2019) In Scientific Reports 9(1).
Abstract
The role of diet in type 1 diabetes development is poorly understood. Metabolites, which reflect dietary response, may help elucidate this role. We explored metabolomics and lipidomics differences between 352 cases of islet autoimmunity (IA) and controls in the TEDDY (The Environmental Determinants of Diabetes in the Young) study. We created dietary patterns reflecting pre-IA metabolite differences between groups and examined their association with IA. Secondary outcomes included IA cases positive for multiple autoantibodies (mAb+). The association of 853 plasma metabolites with outcomes was tested at seroconversion to IA, just prior to seroconversion, and during infancy. Key compounds in enriched metabolite sets were used to create... (More)
The role of diet in type 1 diabetes development is poorly understood. Metabolites, which reflect dietary response, may help elucidate this role. We explored metabolomics and lipidomics differences between 352 cases of islet autoimmunity (IA) and controls in the TEDDY (The Environmental Determinants of Diabetes in the Young) study. We created dietary patterns reflecting pre-IA metabolite differences between groups and examined their association with IA. Secondary outcomes included IA cases positive for multiple autoantibodies (mAb+). The association of 853 plasma metabolites with outcomes was tested at seroconversion to IA, just prior to seroconversion, and during infancy. Key compounds in enriched metabolite sets were used to create dietary patterns reflecting metabolite composition, which were then tested for association with outcomes in the nested case-control subset and the full TEDDY cohort. Unsaturated phosphatidylcholines, sphingomyelins, phosphatidylethanolamines, glucosylceramides, and phospholipid ethers in infancy were inversely associated with mAb+ risk, while dicarboxylic acids were associated with an increased risk. An infancy dietary pattern representing higher levels of unsaturated phosphatidylcholines and phospholipid ethers, and lower sphingomyelins was protective for mAb+ in the nested case-control study only. Characterization of this high-risk infant metabolomics profile may help shape the future of early diagnosis or prevention efforts. © 2019, The Author(s). (Less)
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Scientific Reports
volume
9
issue
1
article number
14819
publisher
Nature Publishing Group
external identifiers
  • scopus:85073451757
  • pmid:31616039
ISSN
2045-2322
DOI
10.1038/s41598-019-51251-4
language
English
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Export Date: 28 October 2019
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4093762d-1d72-4627-ab46-e0e9a6d8f362
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2019-10-28 12:19:08
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2020-04-02 02:43:42
@article{4093762d-1d72-4627-ab46-e0e9a6d8f362,
  abstract     = {The role of diet in type 1 diabetes development is poorly understood. Metabolites, which reflect dietary response, may help elucidate this role. We explored metabolomics and lipidomics differences between 352 cases of islet autoimmunity (IA) and controls in the TEDDY (The Environmental Determinants of Diabetes in the Young) study. We created dietary patterns reflecting pre-IA metabolite differences between groups and examined their association with IA. Secondary outcomes included IA cases positive for multiple autoantibodies (mAb+). The association of 853 plasma metabolites with outcomes was tested at seroconversion to IA, just prior to seroconversion, and during infancy. Key compounds in enriched metabolite sets were used to create dietary patterns reflecting metabolite composition, which were then tested for association with outcomes in the nested case-control subset and the full TEDDY cohort. Unsaturated phosphatidylcholines, sphingomyelins, phosphatidylethanolamines, glucosylceramides, and phospholipid ethers in infancy were inversely associated with mAb+ risk, while dicarboxylic acids were associated with an increased risk. An infancy dietary pattern representing higher levels of unsaturated phosphatidylcholines and phospholipid ethers, and lower sphingomyelins was protective for mAb+ in the nested case-control study only. Characterization of this high-risk infant metabolomics profile may help shape the future of early diagnosis or prevention efforts. © 2019, The Author(s).},
  author       = {Johnson, Randi K.  and Lernmark, Åke and Andrén Aronsson, Carin and Ask, Maria and Bremer, Jenny and Cilio, Corrado and Ericson-Hallström, Emelie and Björne Fors, Annika and Fransson, Lina and Gard, Thomas and Bennet, Rasmus and Hansen, Monica and Hyberg-Karlsson, Suzanne and Jisser, Hanna and Johansen, Fredrik and Jónsdóttir, Berglind and JOVIC, SILVIJA and Elding Larsson, Helena and Lindström, Marielle and Lundgren, Markus and Månsson Martinez, Maria and Markan, Maria and Melin, Marie Jessica and Mestan, Zeliha and Nilsson, Caroline N and Ottosson, Karin and Rahmati, Kobra and Ramelius, Anita and Salami, Falastin and Sjöberg, Anette and Sjöberg, Birgitta and Törn, Carina and Wallin, Anne and Wimar, Åsa and Åberg, Sofie and Norris, Jill M},
  issn         = {2045-2322},
  language     = {eng},
  number       = {1},
  publisher    = {Nature Publishing Group},
  series       = {Scientific Reports},
  title        = {Metabolite-related dietary patterns and the development of islet autoimmunity},
  url          = {http://dx.doi.org/10.1038/s41598-019-51251-4},
  doi          = {10.1038/s41598-019-51251-4},
  volume       = {9},
  year         = {2019},
}