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Dietary vitamin D intake and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition: the EPIC-InterAct study

Abbas, S.; Linseisen, J.; Rohrmann, S.; Beulens, J. W. J.; Buijsse, B.; Amiano, P.; Ardanaz, E.; Balkau, B.; Boeing, H. and Clavel-Chapelon, F., et al. (2014) In European Journal of Clinical Nutrition 68(2). p.196-202
Abstract
BACKGROUND/OBJECTIVES: Prospective cohort studies have indicated that serum vitamin D levels are inversely related to risk of type 2 diabetes. However, such studies cannot determine the source of vitamin D. Therefore, we examined the association of dietary vitamin D intake with incident type 2 diabetes within the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct study in a heterogeneous European population including eight countries with large geographical variation. SUBJECTS/METHODS: Using a case-cohort design, 11 245 incident cases of type 2 diabetes and a representative subcohort (N = 15 798) were included in the analyses. Hazard ratios (HR) and 95% confidence intervals (CIs) for type 2 diabetes were calculated... (More)
BACKGROUND/OBJECTIVES: Prospective cohort studies have indicated that serum vitamin D levels are inversely related to risk of type 2 diabetes. However, such studies cannot determine the source of vitamin D. Therefore, we examined the association of dietary vitamin D intake with incident type 2 diabetes within the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct study in a heterogeneous European population including eight countries with large geographical variation. SUBJECTS/METHODS: Using a case-cohort design, 11 245 incident cases of type 2 diabetes and a representative subcohort (N = 15 798) were included in the analyses. Hazard ratios (HR) and 95% confidence intervals (CIs) for type 2 diabetes were calculated using a Prentice-weighted Cox regression adjusted for potential confounders. Twenty-four-hour diet-recall data from a subsample (N = 2347) were used to calibrate habitual intake data derived from dietary questionnaires. RESULTS: Median follow-up time was 10.8 years. Dietary vitamin D intake was not significantly associated with the risk of type 2 diabetes. HR and 95% CIs for the highest compared to the lowest quintile of uncalibrated vitamin D intake was 1.09 (0.97-1.22) (P-trend = 0.17). No associations were observed in a sex-specific analysis. The overall pooled effect (HR (95% CI)) using the continuous calibrated variable was 1.00 (0.97-1.03) per increase of 1 mg/day dietary vitamin D. CONCLUSIONS: This observational study does not support an association between higher dietary vitamin D intake and type 2 diabetes incidence. This result has to be interpreted in light of the limited contribution of dietary vitamin D on the overall vitamin D status of a person. (Less)
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publication status
published
subject
keywords
vitamin D, type 2 diabetes, dietary intake, observational study, EPIC
in
European Journal of Clinical Nutrition
volume
68
issue
2
pages
196 - 202
publisher
Nature Publishing Group
external identifiers
  • wos:000331292200011
  • scopus:84893740785
ISSN
1476-5640
DOI
10.1038/ejcn.2013.235
language
English
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yes
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5960ac52-0f64-40a7-8e1d-dca8b68de166 (old id 4368340)
date added to LUP
2014-04-07 09:20:44
date last changed
2017-01-01 05:28:25
@article{5960ac52-0f64-40a7-8e1d-dca8b68de166,
  abstract     = {BACKGROUND/OBJECTIVES: Prospective cohort studies have indicated that serum vitamin D levels are inversely related to risk of type 2 diabetes. However, such studies cannot determine the source of vitamin D. Therefore, we examined the association of dietary vitamin D intake with incident type 2 diabetes within the European Prospective Investigation into Cancer and Nutrition (EPIC)-InterAct study in a heterogeneous European population including eight countries with large geographical variation. SUBJECTS/METHODS: Using a case-cohort design, 11 245 incident cases of type 2 diabetes and a representative subcohort (N = 15 798) were included in the analyses. Hazard ratios (HR) and 95% confidence intervals (CIs) for type 2 diabetes were calculated using a Prentice-weighted Cox regression adjusted for potential confounders. Twenty-four-hour diet-recall data from a subsample (N = 2347) were used to calibrate habitual intake data derived from dietary questionnaires. RESULTS: Median follow-up time was 10.8 years. Dietary vitamin D intake was not significantly associated with the risk of type 2 diabetes. HR and 95% CIs for the highest compared to the lowest quintile of uncalibrated vitamin D intake was 1.09 (0.97-1.22) (P-trend = 0.17). No associations were observed in a sex-specific analysis. The overall pooled effect (HR (95% CI)) using the continuous calibrated variable was 1.00 (0.97-1.03) per increase of 1 mg/day dietary vitamin D. CONCLUSIONS: This observational study does not support an association between higher dietary vitamin D intake and type 2 diabetes incidence. This result has to be interpreted in light of the limited contribution of dietary vitamin D on the overall vitamin D status of a person.},
  author       = {Abbas, S. and Linseisen, J. and Rohrmann, S. and Beulens, J. W. J. and Buijsse, B. and Amiano, P. and Ardanaz, E. and Balkau, B. and Boeing, H. and Clavel-Chapelon, F. and Fagherazzi, G. and Franks, Paul and Gavrila, D. and Grioni, S. and Kaaks, R. and Key, T. J. and Khaw, K. T. and Kuehn, T. and Mattiello, A. and Molina-Montes, E. and Nilsson, P. M. and Overvad, K. and Quiros, J. R. and Rolandsson, O. and Sacerdote, C. and Saieva, C. and Slimani, N. and Sluijs, I. and Spijkerman, A. M. W. and Tjonneland, A. and Tumino, R. and van der A, D. L. and Zamora-Ros, R. and Sharp, S. J. and Langenberg, C. and Forouhi, N. G. and Riboli, E. and Wareham, N. J.},
  issn         = {1476-5640},
  keyword      = {vitamin D,type 2 diabetes,dietary intake,observational study,EPIC},
  language     = {eng},
  number       = {2},
  pages        = {196--202},
  publisher    = {Nature Publishing Group},
  series       = {European Journal of Clinical Nutrition},
  title        = {Dietary vitamin D intake and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition: the EPIC-InterAct study},
  url          = {http://dx.doi.org/10.1038/ejcn.2013.235},
  volume       = {68},
  year         = {2014},
}