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Chloroplast thylakoids reduce glucose uptake and decrease intestinal macromolecular permeability.

Montelius, Caroline LU ; Gustafsson, Karolina LU orcid ; Weström, Björn LU ; Albertsson, Per-Åke LU ; Emek, Sinan Cem LU ; Rayner, Marilyn LU orcid and Erlanson-Albertsson, Charlotte LU (2011) In British Journal of Nutrition 106(6). p.836-844
Abstract
Thylakoid membranes, derived from chloroplasts, have previously been shown to retard fat digestion and lower blood glucose levels after oral intake. The purpose of the present study was to investigate the effect of thylakoid membranes on the passage of methyl-glucose, dextran and ovalbumin over rat intestine in vitro using Ussing chambers. The results show that thylakoids retard the passage of each of the test molecules in a dose-dependent way. The thylakoids appear to be attached on the mucosal surface and a mechanism is suggested that the thylakoids delay the passage of the test molecules by sterical hindrance. The present results indicate that thylakoid membranes may be useful both to control intestinal absorption of glucose and to... (More)
Thylakoid membranes, derived from chloroplasts, have previously been shown to retard fat digestion and lower blood glucose levels after oral intake. The purpose of the present study was to investigate the effect of thylakoid membranes on the passage of methyl-glucose, dextran and ovalbumin over rat intestine in vitro using Ussing chambers. The results show that thylakoids retard the passage of each of the test molecules in a dose-dependent way. The thylakoids appear to be attached on the mucosal surface and a mechanism is suggested that the thylakoids delay the passage of the test molecules by sterical hindrance. The present results indicate that thylakoid membranes may be useful both to control intestinal absorption of glucose and to enhance the barrier function of the intestine. (Less)
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author
; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
3-O-Methylglucose, Animals, Area Under Curve, Chloroplasts, Dextrans, Dose-Response Relationship, Drug, Glucose, Intestines, Macromolecular Substances, Mice, Ovalbumin, Permeability, Rats, Rats, Sprague-Dawley, Spinacia oleracea, Thylakoids, Time Factors
in
British Journal of Nutrition
volume
106
issue
6
pages
9 pages
publisher
Cambridge University Press
external identifiers
  • wos:000295403000007
  • pmid:21736841
  • scopus:80555156797
  • pmid:21736841
ISSN
1475-2662
DOI
10.1017/S0007114511001267
language
English
LU publication?
yes
id
4e5b1723-903f-431d-b794-21acefcc384e (old id 2058877)
date added to LUP
2016-04-04 07:31:03
date last changed
2025-04-04 15:01:41
@article{4e5b1723-903f-431d-b794-21acefcc384e,
  abstract     = {{Thylakoid membranes, derived from chloroplasts, have previously been shown to retard fat digestion and lower blood glucose levels after oral intake. The purpose of the present study was to investigate the effect of thylakoid membranes on the passage of methyl-glucose, dextran and ovalbumin over rat intestine in vitro using Ussing chambers. The results show that thylakoids retard the passage of each of the test molecules in a dose-dependent way. The thylakoids appear to be attached on the mucosal surface and a mechanism is suggested that the thylakoids delay the passage of the test molecules by sterical hindrance. The present results indicate that thylakoid membranes may be useful both to control intestinal absorption of glucose and to enhance the barrier function of the intestine.}},
  author       = {{Montelius, Caroline and Gustafsson, Karolina and Weström, Björn and Albertsson, Per-Åke and Emek, Sinan Cem and Rayner, Marilyn and Erlanson-Albertsson, Charlotte}},
  issn         = {{1475-2662}},
  keywords     = {{3-O-Methylglucose; Animals; Area Under Curve; Chloroplasts; Dextrans; Dose-Response Relationship, Drug; Glucose; Intestines; Macromolecular Substances; Mice; Ovalbumin; Permeability; Rats; Rats, Sprague-Dawley; Spinacia oleracea; Thylakoids; Time Factors}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{836--844}},
  publisher    = {{Cambridge University Press}},
  series       = {{British Journal of Nutrition}},
  title        = {{Chloroplast thylakoids reduce glucose uptake and decrease intestinal macromolecular permeability.}},
  url          = {{http://dx.doi.org/10.1017/S0007114511001267}},
  doi          = {{10.1017/S0007114511001267}},
  volume       = {{106}},
  year         = {{2011}},
}