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A prospective study on dietary fat and incidence of prostate cancer (Malmö, Sweden).

Wallström, Peter LU ; Bjartell, Anders LU ; Gullberg, Bo LU ; Olsson, Håkan LU and Wirfält, Elisabet LU (2007) In Cancer Causes and Control 18(10). p.1107-1121
Abstract
To study the associations between intake of various types of fat and risk of prostate cancer (PCa) in a population-based cohort. We have studied 10,564 initially cancer-free men of the Malmo Diet and Cancer cohort, aged 45-73 years. Diet was assessed by a modified diet history method. Cases and clinical characteristics were ascertained via national and regional registry data. During a mean follow-up of 11.0 years, 817 incidental PCa cases were diagnosed. Out of these, 281 were classified as advanced. There were 202 cases occurring before 65 years of age. After adjustment for age and energy intake, there was no association between intake of any types of fat and risk of PCa, or between fat intake and advanced PCa or PCa occurring in persons... (More)
To study the associations between intake of various types of fat and risk of prostate cancer (PCa) in a population-based cohort. We have studied 10,564 initially cancer-free men of the Malmo Diet and Cancer cohort, aged 45-73 years. Diet was assessed by a modified diet history method. Cases and clinical characteristics were ascertained via national and regional registry data. During a mean follow-up of 11.0 years, 817 incidental PCa cases were diagnosed. Out of these, 281 were classified as advanced. There were 202 cases occurring before 65 years of age. After adjustment for age and energy intake, there was no association between intake of any types of fat and risk of PCa, or between fat intake and advanced PCa or PCa occurring in persons aged < 65 years. However, we observed positive associations between intakes of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and risk of PCa. After adjustment for multiple confounders, the latter associations were weakened, but the results were otherwise virtually unchanged. This large study, with high-validity dietary data, does not support an association between intake of total, saturated, or mono-unsaturated fat and PCa risk. The observed associations between EPA/DHA intakes and PCa are difficult to interpret. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
prostatic-neoplasms, dietary-fats, cohort-studies, fatty-acids
in
Cancer Causes and Control
volume
18
issue
10
pages
1107 - 1121
publisher
Springer
external identifiers
  • wos:000249813500006
  • scopus:34848815086
ISSN
1573-7225
DOI
10.1007/s10552-007-9050-4
language
English
LU publication?
yes
id
72389179-780a-4d72-adcf-8c03c5137e44 (old id 606572)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17726648&dopt=Abstract
date added to LUP
2007-12-19 14:18:10
date last changed
2017-09-17 04:34:39
@article{72389179-780a-4d72-adcf-8c03c5137e44,
  abstract     = {To study the associations between intake of various types of fat and risk of prostate cancer (PCa) in a population-based cohort. We have studied 10,564 initially cancer-free men of the Malmo Diet and Cancer cohort, aged 45-73 years. Diet was assessed by a modified diet history method. Cases and clinical characteristics were ascertained via national and regional registry data. During a mean follow-up of 11.0 years, 817 incidental PCa cases were diagnosed. Out of these, 281 were classified as advanced. There were 202 cases occurring before 65 years of age. After adjustment for age and energy intake, there was no association between intake of any types of fat and risk of PCa, or between fat intake and advanced PCa or PCa occurring in persons aged &lt; 65 years. However, we observed positive associations between intakes of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) and risk of PCa. After adjustment for multiple confounders, the latter associations were weakened, but the results were otherwise virtually unchanged. This large study, with high-validity dietary data, does not support an association between intake of total, saturated, or mono-unsaturated fat and PCa risk. The observed associations between EPA/DHA intakes and PCa are difficult to interpret.},
  author       = {Wallström, Peter and Bjartell, Anders and Gullberg, Bo and Olsson, Håkan and Wirfält, Elisabet},
  issn         = {1573-7225},
  keyword      = {prostatic-neoplasms,dietary-fats,cohort-studies,fatty-acids},
  language     = {eng},
  number       = {10},
  pages        = {1107--1121},
  publisher    = {Springer},
  series       = {Cancer Causes and Control},
  title        = {A prospective study on dietary fat and incidence of prostate cancer (Malmö, Sweden).},
  url          = {http://dx.doi.org/10.1007/s10552-007-9050-4},
  volume       = {18},
  year         = {2007},
}