High folate intake is associated with lower breast cancer incidence in postmenopausal women in the Malmö Diet and Cancer cohort
(2007) In American Journal of Clinical Nutrition 86(2). p.43-434- Abstract
BACKGROUND: Epidemiologic studies of associations between folate intake and breast cancer are inconclusive, but folate and other plant food nutrients appear protective in women at elevated risk.
OBJECTIVE: The objective was to examine the association between folate intake and the incidence of postmenopausal breast cancer.
DESIGN: This prospective study included all women aged >or=50 y (n = 11699) from the Malmö Diet and Cancer cohort. The mean follow-up time was 9.5 y. We used a modified diet-history method to collect nutrient intake data. At the end of follow-up, 392 incident invasive breast cancer cases were verified. We used proportional hazard regression to calculate hazard ratios (HRs).
RESULTS: Compared with... (More)
BACKGROUND: Epidemiologic studies of associations between folate intake and breast cancer are inconclusive, but folate and other plant food nutrients appear protective in women at elevated risk.
OBJECTIVE: The objective was to examine the association between folate intake and the incidence of postmenopausal breast cancer.
DESIGN: This prospective study included all women aged >or=50 y (n = 11699) from the Malmö Diet and Cancer cohort. The mean follow-up time was 9.5 y. We used a modified diet-history method to collect nutrient intake data. At the end of follow-up, 392 incident invasive breast cancer cases were verified. We used proportional hazard regression to calculate hazard ratios (HRs).
RESULTS: Compared with the lowest quintile, the incidence of invasive breast cancer was reduced in the highest quintile of dietary folate intake (HR: 0.56; 95% CI: 0.35, 0.90; P for trend = 0.02); total folate intake, including supplements (HR: 0.56; 95% CI: 0.34, 0.91; P for trend = 0.006); and dietary folate equivalents (HR: 0.59; 95% CI: 0.36, 0.97; P for trend = 0.01).
CONCLUSION: A high folate intake was associated with a lower incidence of postmenopausal breast cancer in this cohort.
(Less)
- author
- Ericson, Ulrika
LU
; Sonestedt, Emily
LU
; Gullberg, Bo LU ; Olsson, Håkan LU
and Wirfält, Elisabet LU
- organization
- publishing date
- 2007-08
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Aged, Alcohol Drinking, Breast Neoplasms, Cohort Studies, Female, Folic Acid, Humans, Incidence, Leisure Activities, Middle Aged, Neoplasm Invasiveness, Postmenopause, Proportional Hazards Models, Smoking, Socioeconomic Factors, Sweden
- in
- American Journal of Clinical Nutrition
- volume
- 86
- issue
- 2
- pages
- 10 pages
- publisher
- Elsevier
- external identifiers
-
- pmid:17684216
- scopus:34547884338
- ISSN
- 0002-9165
- language
- English
- LU publication?
- yes
- id
- 693c5be5-5623-49ed-b6c4-d80bea61f1e0
- date added to LUP
- 2016-09-18 12:13:10
- date last changed
- 2025-01-12 11:22:36
@article{693c5be5-5623-49ed-b6c4-d80bea61f1e0, abstract = {{<p>BACKGROUND: Epidemiologic studies of associations between folate intake and breast cancer are inconclusive, but folate and other plant food nutrients appear protective in women at elevated risk.</p><p>OBJECTIVE: The objective was to examine the association between folate intake and the incidence of postmenopausal breast cancer.</p><p>DESIGN: This prospective study included all women aged >or=50 y (n = 11699) from the Malmö Diet and Cancer cohort. The mean follow-up time was 9.5 y. We used a modified diet-history method to collect nutrient intake data. At the end of follow-up, 392 incident invasive breast cancer cases were verified. We used proportional hazard regression to calculate hazard ratios (HRs).</p><p>RESULTS: Compared with the lowest quintile, the incidence of invasive breast cancer was reduced in the highest quintile of dietary folate intake (HR: 0.56; 95% CI: 0.35, 0.90; P for trend = 0.02); total folate intake, including supplements (HR: 0.56; 95% CI: 0.34, 0.91; P for trend = 0.006); and dietary folate equivalents (HR: 0.59; 95% CI: 0.36, 0.97; P for trend = 0.01).</p><p>CONCLUSION: A high folate intake was associated with a lower incidence of postmenopausal breast cancer in this cohort.</p>}}, author = {{Ericson, Ulrika and Sonestedt, Emily and Gullberg, Bo and Olsson, Håkan and Wirfält, Elisabet}}, issn = {{0002-9165}}, keywords = {{Aged; Alcohol Drinking; Breast Neoplasms; Cohort Studies; Female; Folic Acid; Humans; Incidence; Leisure Activities; Middle Aged; Neoplasm Invasiveness; Postmenopause; Proportional Hazards Models; Smoking; Socioeconomic Factors; Sweden}}, language = {{eng}}, number = {{2}}, pages = {{43--434}}, publisher = {{Elsevier}}, series = {{American Journal of Clinical Nutrition}}, title = {{High folate intake is associated with lower breast cancer incidence in postmenopausal women in the Malmö Diet and Cancer cohort}}, volume = {{86}}, year = {{2007}}, }