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Dietary supplementation with β-glucan enriched oat bran increases faecal concentration of carboxylic acids in healthy subjects

Nilsson, Ulf LU ; Johansson, M; Nilsson, Å; Björck, Inger LU and Nyman, Margareta LU (2008) In European Journal of Clinical Nutrition 62(8). p.978-984
Abstract
Background/Objective: Carboxylic acids (CAs), especially butyric acid, have been suggested to counteract colonic diseases, such as ulcerative colitis and colon cancer. Colonic formation of CAs can be influenced by the diet, but the concentrations and pattern formed need to be evaluated for different food products in humans. To elucidate how the colonic concentration of CAs in healthy subjects is influenced by dietary supplementation with oat bran, and whether the concentration varies over time and during consecutive days. Subjects/Methods: Twenty-five healthy subjects ( age 24 +/- 1.3) were recruited to the study. The subjects were given 40 g beta-glucan enriched oat bran per day, corresponding to 20 g dietary fibre, in 4 slices of bread.... (More)
Background/Objective: Carboxylic acids (CAs), especially butyric acid, have been suggested to counteract colonic diseases, such as ulcerative colitis and colon cancer. Colonic formation of CAs can be influenced by the diet, but the concentrations and pattern formed need to be evaluated for different food products in humans. To elucidate how the colonic concentration of CAs in healthy subjects is influenced by dietary supplementation with oat bran, and whether the concentration varies over time and during consecutive days. Subjects/Methods: Twenty-five healthy subjects ( age 24 +/- 1.3) were recruited to the study. The subjects were given 40 g beta-glucan enriched oat bran per day, corresponding to 20 g dietary fibre, in 4 slices of bread. CAs were analysed in faeces during three consecutive days after 0, 4, 8 and 12 weeks on this diet. Results: The concentration of acetic, propionic, butyric, isobutyric and isovaleric acid was higher (P<0.05-0.001) after 8 weeks on the oat bran diet as compared with values at entry, whereas that of lactic acid was lower (P<0.05).After 12 weeks, the concentrations of acetic, propionic and isobutyric acid were still higher and that of lactic acid lower. The variation between individuals was considerable, whereas in the same individuals there was little variation. Conclusions: Oat bran increased the faecal concentration of CAs after 8 weeks, indicating an increased concentration also in the distal colon. The concentration of all main acids increased, except for lactic acid, which decreased. Oat bran may therefore have a preventive potential adjunct to colonic diseases. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
humans, carboxylic acids, beta-glucans, oat bran, dietary fibre
in
European Journal of Clinical Nutrition
volume
62
issue
8
pages
978 - 984
publisher
Nature Publishing Group
external identifiers
  • wos:000258220700006
  • scopus:49349084076
ISSN
1476-5640
DOI
10.1038/sj.ejcn.1602816
language
English
LU publication?
yes
id
f5bc2eb1-d858-4f73-bea9-23b9f1c26728 (old id 757479)
date added to LUP
2007-12-18 15:53:36
date last changed
2017-09-03 04:24:42
@article{f5bc2eb1-d858-4f73-bea9-23b9f1c26728,
  abstract     = {Background/Objective: Carboxylic acids (CAs), especially butyric acid, have been suggested to counteract colonic diseases, such as ulcerative colitis and colon cancer. Colonic formation of CAs can be influenced by the diet, but the concentrations and pattern formed need to be evaluated for different food products in humans. To elucidate how the colonic concentration of CAs in healthy subjects is influenced by dietary supplementation with oat bran, and whether the concentration varies over time and during consecutive days. Subjects/Methods: Twenty-five healthy subjects ( age 24 +/- 1.3) were recruited to the study. The subjects were given 40 g beta-glucan enriched oat bran per day, corresponding to 20 g dietary fibre, in 4 slices of bread. CAs were analysed in faeces during three consecutive days after 0, 4, 8 and 12 weeks on this diet. Results: The concentration of acetic, propionic, butyric, isobutyric and isovaleric acid was higher (P&lt;0.05-0.001) after 8 weeks on the oat bran diet as compared with values at entry, whereas that of lactic acid was lower (P&lt;0.05).After 12 weeks, the concentrations of acetic, propionic and isobutyric acid were still higher and that of lactic acid lower. The variation between individuals was considerable, whereas in the same individuals there was little variation. Conclusions: Oat bran increased the faecal concentration of CAs after 8 weeks, indicating an increased concentration also in the distal colon. The concentration of all main acids increased, except for lactic acid, which decreased. Oat bran may therefore have a preventive potential adjunct to colonic diseases.},
  author       = {Nilsson, Ulf and Johansson, M and Nilsson, Å and Björck, Inger and Nyman, Margareta},
  issn         = {1476-5640},
  keyword      = {humans,carboxylic acids,beta-glucans,oat bran,dietary fibre},
  language     = {eng},
  number       = {8},
  pages        = {978--984},
  publisher    = {Nature Publishing Group},
  series       = {European Journal of Clinical Nutrition},
  title        = {Dietary supplementation with β-glucan enriched oat bran increases faecal concentration of carboxylic acids in healthy subjects},
  url          = {http://dx.doi.org/10.1038/sj.ejcn.1602816},
  volume       = {62},
  year         = {2008},
}