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Inflammatory potential of the diet and association with risk of differentiated thyroid cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort

Lécuyer, Lucie ; Laouali, Nasser ; Dossus, Laure ; Shivappa, Nitin ; Hébert, James R. ; Agudo, Antonio ; Tjonneland, Anne ; Halkjaer, Jytte ; Overvad, Kim and Katzke, Verena A. , et al. (2022) In European Journal of Nutrition 61(7). p.3625-3635
Abstract

Purpose: Chronic inflammation is thought to initiate or promote differentiated thyroid cancer (DTC) and previous studies have shown that diet can modulate this inflammatory process. We aimed to evaluate the association of several dietary scores reflecting the inflammatory potential of the diet with DTC risk. Methods: Within the EPIC cohort, 450,063 participants were followed during a mean period of 14 years, and 712 newly incident DTC cases were identified. Associations between four dietary inflammatory scores [the dietary inflammatory index (DII®) and two energy-adjusted derivatives (the E-DIIr and the E-DIId), and the Inflammatory Score of the Diet (ISD)] and DTC risk were evaluated in the EPIC cohort... (More)

Purpose: Chronic inflammation is thought to initiate or promote differentiated thyroid cancer (DTC) and previous studies have shown that diet can modulate this inflammatory process. We aimed to evaluate the association of several dietary scores reflecting the inflammatory potential of the diet with DTC risk. Methods: Within the EPIC cohort, 450,063 participants were followed during a mean period of 14 years, and 712 newly incident DTC cases were identified. Associations between four dietary inflammatory scores [the dietary inflammatory index (DII®) and two energy-adjusted derivatives (the E-DIIr and the E-DIId), and the Inflammatory Score of the Diet (ISD)] and DTC risk were evaluated in the EPIC cohort using multivariable Cox regression models. Results: Positive associations were observed between DTC risk and the DIIs (HR for 1 SD increase in DII: 1.11, 95%CI: 1.01, 1.23, similar results for its derivatives), but not with the ISD (HR for 1 SD increase: 1.04, 95% CI 0.93, 1.16). Conclusion: Diet-associated inflammation, as estimated by the DII and its derivatives, was weakly positively associated with DTC risk in a European adult population. These results suggesting that diet-associated inflammation acts in the etiology of DTC need to be validated in independent studies.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Cohort, Diet, EPIC, Inflammation, Thyroid cancer
in
European Journal of Nutrition
volume
61
issue
7
pages
3625 - 3635
publisher
Springer
external identifiers
  • scopus:85131095883
  • pmid:35635567
ISSN
1436-6207
DOI
10.1007/s00394-022-02897-w
language
English
LU publication?
yes
id
7a8da500-cb96-40c6-8fc4-c7e60956f8de
date added to LUP
2022-12-28 09:45:49
date last changed
2023-12-05 23:54:53
@article{7a8da500-cb96-40c6-8fc4-c7e60956f8de,
  abstract     = {{<p>Purpose: Chronic inflammation is thought to initiate or promote differentiated thyroid cancer (DTC) and previous studies have shown that diet can modulate this inflammatory process. We aimed to evaluate the association of several dietary scores reflecting the inflammatory potential of the diet with DTC risk. Methods: Within the EPIC cohort, 450,063 participants were followed during a mean period of 14 years, and 712 newly incident DTC cases were identified. Associations between four dietary inflammatory scores [the dietary inflammatory index (DII<sup>®</sup>) and two energy-adjusted derivatives (the E-DII<sub>r</sub> and the E-DII<sub>d</sub>), and the Inflammatory Score of the Diet (ISD)] and DTC risk were evaluated in the EPIC cohort using multivariable Cox regression models. Results: Positive associations were observed between DTC risk and the DIIs (HR for 1 SD increase in DII: 1.11, 95%CI: 1.01, 1.23, similar results for its derivatives), but not with the ISD (HR for 1 SD increase: 1.04, 95% CI 0.93, 1.16). Conclusion: Diet-associated inflammation, as estimated by the DII and its derivatives, was weakly positively associated with DTC risk in a European adult population. These results suggesting that diet-associated inflammation acts in the etiology of DTC need to be validated in independent studies.</p>}},
  author       = {{Lécuyer, Lucie and Laouali, Nasser and Dossus, Laure and Shivappa, Nitin and Hébert, James R. and Agudo, Antonio and Tjonneland, Anne and Halkjaer, Jytte and Overvad, Kim and Katzke, Verena A. and Le Cornet, Charlotte and Schulze, Matthias B. and Jannasch, Franziska and Palli, Domenico and Agnoli, Claudia and Tumino, Rosario and Dragna, Luca and Iannuzzo, Gabriella and Jensen, Torill Enget and Brustad, Magritt and Skeie, Guri and Zamora-Ros, Raul and Rodriguez-Barranco, Miguel and Amiano, Pilar and Chirlaque, María Dolores and Ardanaz, Eva and Almquist, Martin and Sonestedt, Emily and Sandström, Maria and Nilsson, Lena Maria and Weiderpass, Elisabete and Huybrechts, Inge and Rinaldi, Sabina and Boutron-Ruault, Marie Christine and Truong, Thérèse}},
  issn         = {{1436-6207}},
  keywords     = {{Cohort; Diet; EPIC; Inflammation; Thyroid cancer}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{3625--3635}},
  publisher    = {{Springer}},
  series       = {{European Journal of Nutrition}},
  title        = {{Inflammatory potential of the diet and association with risk of differentiated thyroid cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort}},
  url          = {{http://dx.doi.org/10.1007/s00394-022-02897-w}},
  doi          = {{10.1007/s00394-022-02897-w}},
  volume       = {{61}},
  year         = {{2022}},
}