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Serotonin (5-HT) receptor 2b activation augments glucose-stimulated insulin secretion in human and mouse islets of Langerhans.

Bennet, Hedvig LU ; Mollet, Ines LU ; Balhuizen, Alexander LU ; Medina Benavente, Anya LU ; Nagorny, Cecilia LU ; Bagge, Annika LU ; Fadista, Joao LU ; Ottosson Laakso, Emilia LU ; Vikman, Petter LU and Dekker Nitert, Marloes LU , et al. (2016) In Diabetologia 59(4). p.744-754
Abstract
The Gq-coupled 5-hydroxytryptamine 2B (5-HT2B) receptor is known to regulate the proliferation of islet beta cells during pregnancy. However, the role of serotonin in the control of insulin release is still controversial. The aim of the present study was to explore the role of the 5-HT2B receptor in the regulation of insulin secretion in mouse and human islets, as well as in clonal INS-1(832/13) cells.
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type
Contribution to journal
publication status
published
subject
in
Diabetologia
volume
59
issue
4
pages
744 - 754
publisher
Springer Verlag
external identifiers
  • pmid:26733006
  • scopus:84959556025
  • wos:000371802700013
ISSN
1432-0428
DOI
10.1007/s00125-015-3847-6
language
English
LU publication?
yes
id
ca5cab25-bfd2-4c97-897f-70d1ed2d7448 (old id 8593036)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/26733006?dopt=Abstract
date added to LUP
2016-02-01 21:32:46
date last changed
2017-11-05 04:39:58
@article{ca5cab25-bfd2-4c97-897f-70d1ed2d7448,
  abstract     = {The Gq-coupled 5-hydroxytryptamine 2B (5-HT2B) receptor is known to regulate the proliferation of islet beta cells during pregnancy. However, the role of serotonin in the control of insulin release is still controversial. The aim of the present study was to explore the role of the 5-HT2B receptor in the regulation of insulin secretion in mouse and human islets, as well as in clonal INS-1(832/13) cells.},
  author       = {Bennet, Hedvig and Mollet, Ines and Balhuizen, Alexander and Medina Benavente, Anya and Nagorny, Cecilia and Bagge, Annika and Fadista, Joao and Ottosson Laakso, Emilia and Vikman, Petter and Dekker Nitert, Marloes and Eliasson, Lena and Wierup, Nils and Artner, Isabella and Fex, Malin},
  issn         = {1432-0428},
  language     = {eng},
  month        = {01},
  number       = {4},
  pages        = {744--754},
  publisher    = {Springer Verlag},
  series       = {Diabetologia},
  title        = {Serotonin (5-HT) receptor 2b activation augments glucose-stimulated insulin secretion in human and mouse islets of Langerhans.},
  url          = {http://dx.doi.org/10.1007/s00125-015-3847-6},
  volume       = {59},
  year         = {2016},
}