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Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition

Obón-Santacana, Mireia; Luján-Barroso, Leila; Freisling, Heinz; Naudin, Sabine; Boutron-Ruault, Marie Christine; Mancini, Francesca Romana; Rebours, Vinciane; Kühn, Tilman; Katzke, Verena and Boeing, Heiner, et al. (2019) In International Journal of Cancer
Abstract

Four epidemiologic studies have assessed the association between nut intake and pancreatic cancer risk with contradictory results. The present study aims to investigate the relation between nut intake (including seeds) and pancreatic ductal adenocarcinoma (PDAC) risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to estimate hazards ratio (HR) and 95% confidence intervals (95% CI) for nut intake and PDAC risk. Information on intake of nuts was obtained from the EPIC country-specific dietary questionnaires. After a mean follow-up of 14 years, 476,160 participants were eligible for the present study and included 1,283 PDAC cases. No association was observed... (More)

Four epidemiologic studies have assessed the association between nut intake and pancreatic cancer risk with contradictory results. The present study aims to investigate the relation between nut intake (including seeds) and pancreatic ductal adenocarcinoma (PDAC) risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to estimate hazards ratio (HR) and 95% confidence intervals (95% CI) for nut intake and PDAC risk. Information on intake of nuts was obtained from the EPIC country-specific dietary questionnaires. After a mean follow-up of 14 years, 476,160 participants were eligible for the present study and included 1,283 PDAC cases. No association was observed between consumption of nuts and PDAC risk (highest intake vs nonconsumers: HR, 0.89; 95% CI, 0.72–1.10; p-trend = 0.70). Furthermore, no evidence for effect-measure modification was observed when different subgroups were analyzed. Overall, in EPIC, the highest intake of nuts was not statistically significantly associated with PDAC risk.

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epub
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keywords
diet, EPIC, intake, nuts, pancreatic cancer, prospective cohort study, seeds
in
International Journal of Cancer
publisher
John Wiley & Sons
external identifiers
  • scopus:85067624842
ISSN
0020-7136
DOI
10.1002/ijc.32415
language
English
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yes
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94fa26ec-0ff6-4954-a507-312df9b59356
date added to LUP
2019-07-08 12:29:21
date last changed
2019-07-30 05:06:27
@article{94fa26ec-0ff6-4954-a507-312df9b59356,
  abstract     = {<p>Four epidemiologic studies have assessed the association between nut intake and pancreatic cancer risk with contradictory results. The present study aims to investigate the relation between nut intake (including seeds) and pancreatic ductal adenocarcinoma (PDAC) risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Cox proportional hazards models were used to estimate hazards ratio (HR) and 95% confidence intervals (95% CI) for nut intake and PDAC risk. Information on intake of nuts was obtained from the EPIC country-specific dietary questionnaires. After a mean follow-up of 14 years, 476,160 participants were eligible for the present study and included 1,283 PDAC cases. No association was observed between consumption of nuts and PDAC risk (highest intake vs nonconsumers: HR, 0.89; 95% CI, 0.72–1.10; p-trend = 0.70). Furthermore, no evidence for effect-measure modification was observed when different subgroups were analyzed. Overall, in EPIC, the highest intake of nuts was not statistically significantly associated with PDAC risk.</p>},
  author       = {Obón-Santacana, Mireia and Luján-Barroso, Leila and Freisling, Heinz and Naudin, Sabine and Boutron-Ruault, Marie Christine and Mancini, Francesca Romana and Rebours, Vinciane and Kühn, Tilman and Katzke, Verena and Boeing, Heiner and Tjønneland, Anne and Olsen, Anja and Overvad, Kim and Lasheras, Cristina and Rodríguez-Barranco, Miguel and Amiano, Pilar and Santiuste, Carmen and Ardanaz, Eva and Khaw, Kay Thee and Wareham, Nicholas J. and Schmidt, Julie A. and Aune, Dagfinn and Trichopoulou, Antonia and Thriskos, Paschalis and Peppa, Eleni and Masala, Giovanna and Grioni, Sara and Tumino, Rosario and Panico, Salvatore and Bueno-de-Mesquita, Bas and Sciannameo, Veronica and Vermeulen, Roel and Sonestedt, Emily and Sund, Malin and Weiderpass, Elisabete and Skeie, Guri and González, Carlos A. and Riboli, Elio and Duell, Eric J.},
  issn         = {0020-7136},
  keyword      = {diet,EPIC,intake,nuts,pancreatic cancer,prospective cohort study,seeds},
  language     = {eng},
  month        = {05},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Consumption of nuts and seeds and pancreatic ductal adenocarcinoma risk in the European Prospective Investigation into Cancer and Nutrition},
  url          = {http://dx.doi.org/10.1002/ijc.32415},
  year         = {2019},
}