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Consumption of fruits, vegetables and fruit juices and differentiated thyroid carcinoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

Zamora-Ros, Raul; Béraud, Virginie; Franceschi, Silvia; Cayssials, Valerie; Tsilidis, Konstantinos K.; Boutron-Ruault, Marie Christine; Weiderpass, Elisabete; Overvad, Kim; Tjønneland, Anne and Eriksen, Anne K., et al. (2018) In International Journal of Cancer 142(3). p.449-459
Abstract

Fruit and vegetable (F&V) intake is considered as probably protective against overall cancer risk, but results in previous studies are not consistent for thyroid cancer (TC). The purpose of this study is to examine the association between the consumption of fruits, vegetables, fruit juices and differentiated thyroid cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The EPIC study is a cohort including over half a million participants, recruited between 1991 and 2000. During a mean follow-up of 14 years, 748 incident first primary differentiated TC cases were identified. F&V and fruit juice intakes were assessed through validated country-specific dietary questionnaires. Hazard... (More)

Fruit and vegetable (F&V) intake is considered as probably protective against overall cancer risk, but results in previous studies are not consistent for thyroid cancer (TC). The purpose of this study is to examine the association between the consumption of fruits, vegetables, fruit juices and differentiated thyroid cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The EPIC study is a cohort including over half a million participants, recruited between 1991 and 2000. During a mean follow-up of 14 years, 748 incident first primary differentiated TC cases were identified. F&V and fruit juice intakes were assessed through validated country-specific dietary questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox regression models adjusted for potential confounding factors. Comparing the highest versus lowest quartile of intake, differentiated TC risk was not associated with intakes of total F&V (HR: 0.89; 95% CI: 0.68–1.15; p-trend = 0.44), vegetables (HR: 0.89; 95% CI: 0.69–1.14; p-trend = 0.56), or fruit (HR: 1.00; 95% CI: 0.79–1.26; p-trend = 0.64). No significant association was observed with any individual type of vegetable or fruit. However, there was a positive borderline trend with fruit juice intake (HR: 1.23; 95% CI: 0.98–1.53; p-trend = 0.06). This study did not find any significant association between F&V intakes and differentiated TC risk; however a positive trend with fruit juice intake was observed, possibly related to its high sugar content.

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published
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keywords
EPIC, fruit juices, fruits, intake, thyroid cancer, vegetables
in
International Journal of Cancer
volume
142
issue
3
pages
11 pages
publisher
John Wiley & Sons
external identifiers
  • scopus:85037645748
ISSN
0020-7136
DOI
10.1002/ijc.30880
language
English
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yes
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a166a3bb-4420-4f19-9e24-3cbd3dd0c371
date added to LUP
2018-01-02 12:09:29
date last changed
2018-11-21 21:36:58
@article{a166a3bb-4420-4f19-9e24-3cbd3dd0c371,
  abstract     = {<p>Fruit and vegetable (F&amp;V) intake is considered as probably protective against overall cancer risk, but results in previous studies are not consistent for thyroid cancer (TC). The purpose of this study is to examine the association between the consumption of fruits, vegetables, fruit juices and differentiated thyroid cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC) study. The EPIC study is a cohort including over half a million participants, recruited between 1991 and 2000. During a mean follow-up of 14 years, 748 incident first primary differentiated TC cases were identified. F&amp;V and fruit juice intakes were assessed through validated country-specific dietary questionnaires. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox regression models adjusted for potential confounding factors. Comparing the highest versus lowest quartile of intake, differentiated TC risk was not associated with intakes of total F&amp;V (HR: 0.89; 95% CI: 0.68–1.15; p-trend = 0.44), vegetables (HR: 0.89; 95% CI: 0.69–1.14; p-trend = 0.56), or fruit (HR: 1.00; 95% CI: 0.79–1.26; p-trend = 0.64). No significant association was observed with any individual type of vegetable or fruit. However, there was a positive borderline trend with fruit juice intake (HR: 1.23; 95% CI: 0.98–1.53; p-trend = 0.06). This study did not find any significant association between F&amp;V intakes and differentiated TC risk; however a positive trend with fruit juice intake was observed, possibly related to its high sugar content.</p>},
  author       = {Zamora-Ros, Raul and Béraud, Virginie and Franceschi, Silvia and Cayssials, Valerie and Tsilidis, Konstantinos K. and Boutron-Ruault, Marie Christine and Weiderpass, Elisabete and Overvad, Kim and Tjønneland, Anne and Eriksen, Anne K. and Bonnet, Fabrice and Affret, Aurélie and Katzke, Verena and Kühn, Tilman and Boeing, Heiner and Trichopoulou, Antonia and Valanou, Elisavet and Karakatsani, Anna and Masala, Giovanna and Grioni, Sara and Santucci de Magistris, Maria and Tumino, Rosario and Ricceri, Fulvio and Skeie, Guri and Parr, Christine L. and Merino, Susana and Salamanca-Fernández, Elena and Chirlaque, Maria Dolores and Ardanaz, Eva and Amiano, Pilar and Almquist, Martin and Drake, Isabel and Hennings, Joakim and Sandström, Maria and Bueno-de-Mesquita, H. Bas and Peeters, Petra H. and Khaw, Kay Thee and Wareham, Nicholas J. and Schmidt, Julie A. and Perez-Cornago, Aurora and Aune, Dagfinn and Riboli, Elio and Slimani, Nadia and Scalbert, Augustin and Romieu, Isabelle and Agudo, Antonio and Rinaldi, Sabina},
  issn         = {0020-7136},
  keyword      = {EPIC,fruit juices,fruits,intake,thyroid cancer,vegetables},
  language     = {eng},
  month        = {02},
  number       = {3},
  pages        = {449--459},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Consumption of fruits, vegetables and fruit juices and differentiated thyroid carcinoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study},
  url          = {http://dx.doi.org/10.1002/ijc.30880},
  volume       = {142},
  year         = {2018},
}